CAS: 142356-33-0; Tert-Butyl (6-Bromohexyl)Carbamate

相似化合物

14502-76-2 142356-35-2 142356-34-1

上下游产品

CAS号75937-12-1 6-(叔丁氧羰氨基)-1-己醇 | CAS号603-35-0 三苯基膦 | CAS号4048-33-3 6-氨基-1-己醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号6404-29-1 B°C-6-氨基己酸 | CAS号29823-18-5 7-溴庚酸乙酯 | CAS号75950-19-5 6-(tert-butoxyc... | CAS号794587-35-2 6-bromohexyl is... | CAS号75-65-0 叔丁醇 | CAS号1938-58-5 6-(二甲胺基)己胺

📜7-溴庚酸置于二苯基膦叠氮化物,三乙胺体系中,用 甲苯 用作溶剂,化学反应生成N-Boc-6-溴代己胺
参考文献:Design,Synthesis,And Biological Activity Of Folate Receptor-Targeted Prodrugs Of Thiolate Histone Deacetylase Inhibitors
标题:Design,Synthesis,And Biological Activity Of Folate Receptor-Targeted Prodrugs Of Thiolate Histone Deacetylase Inhibitors
摘要:Aiming To Develop Selective Anticancer Drugs,We Designed And Synthesized Three Disulfides Bearing A Folic Acid Moiety As Candidate Folate Receptor (Fr)-Targeted Prodrugs Of Thiolate Histone Deacetylase Inhibitors. Among Them,Compound 1 Displayed Growth-Inhibitory Activity Toward Folate Receptor-Positive Mcf-7 Breast Cancer Cells. The Activity Of I Was Significantly Reduced By Free Folic Acid,Suggesting That Cellular Uptake Of I Is Mediated By Fr. (C) 2007 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2007.05.040

专利信息

专利号:WO-2025136842-A1
优先权日:2023-12-19
标题 :Process for preparing n-aminoalkylated tryptophan compounds
发明人：CO SARAH S; DALBY STEPHEN M; JOHNSON KEYWAN ALEXANDER; KLAPARS ARTIS; KUETHE JEFFREY T; PETERS BYRON KENNEDY; SIROTA ERIC; WRIGHT TIMOTHY JAMES; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to processes useful in the synthesis of aminohexyl compounds, such as a compound of Formula I or a salt, hydrate and/or solvate thereof, as well as methods for the preparing a compound of Formula I and intermediates used to make a compound of Formula I. The present invention presents a novel method for the selective alkylation of tryptophan analogues, eliminating the need for protecting groups and advancing the field of tryptophan analogue synthesis.

专利号:US-9125942-B2
优先权日:2010-01-19
标题 :Paramagnetic metal-nanodiamond conjugates
发明人：MANUS LISA M; MASTARONE DANIEL J; HO DEAN; MEADE THOMAS J
权利人:MANUS LISA M; MASTARONE DANIEL J; HO DEAN; MEADE THOMAS J; UNIV NORTHWESTERN
摘要:The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.

专利号:US-2025195678-A1
优先权日:2019-10-15
标 题:B-lymphocyte specific amatoxin antibody conjugates
发明人：HECHLER TORSTEN; PAHL ANDREAS; KULKE MICHAEL; MüLLER CHRISTOPH
权利人:HEIDELBERG PHARMA RES GMBH
摘要:The present application relates to a conjugate comprising an amatoxin, a target-binding moiety wherein the target is CD20, i.e., a CD20-binding moiety, and optionally a linker linking said amatoxin and said CD20-binding moiety. The invention further relates to the synthesis of said conjugate. In addition, the invention relates to a pharmaceutical composition comprising such conjugate, particularly for use in the treatment of B-cell and/or lymphoma associated diseases and/or malignancies.

专利号:US-8513451-B2
优先权日:2007-05-30
标 题:Fluorescent phospholipase A2 indicators
发明人：KANG HEE CHOL
权利人:KANG HEE CHOL
摘要:Compositions, methods of synthesis and applications of phospholipase A 2 (PLA 2 ) specific enzyme substrates which exhibit fluorescence resonance energy transfer (FRET) are described. The compounds generally have the structure: (I) wherein, the variables are described throughout the application. These novel compounds provide a sensitive method to monitor real time PLA 2 specific enzyme activities in various cells, tissues and small organisms with fluorescence-ratiometric analysis.