CAS: 13291-18-4; Isopropenylmagnesium Bromide

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CAS号557-93-7 2-溴丙烯 | CAS号4911-54-0 4-甲基-4-戊烯酸乙酯 | CAS号1030239-96-3 1-(cyclohept-1-... | CAS号513-81-5 2,3-二甲基-1,3-丁二烯 | CAS号55170-16-6 1-cyclohexenyl-... | CAS号1712-70-5 4-氯-α-甲基苯乙烯 | CAS号19781-54-5 2,4-二甲基-1-戊烯-3-醇 | CAS号188584-38-5 3-methyl-1-(1,3... | CAS号20432-49-9 3,5-Hexadien-2-... | CAS号20432-43-3 4-methylpenta-2...

2-溴丙烯置于magnesium体系中,用 乙二醇二乙醚 用作溶剂,化学反应生成异丙烯基溴化镁
参考文献:关于绿叶蘑菇的成分,Xxviii.β-甲基-γ-羟基亮氨酸和β-甲基-γ.δ-二羟基亮氨酸的合成,这是两个可能的金刚烷胺构建单元
标题:关于绿叶蘑菇的成分,Xxviii.β-甲基-γ-羟基亮氨酸和β-甲基-γ.δ-二羟基亮氨酸的合成,这是两个可能的金刚烷胺构建单元
摘要:α-氨基-β.γ-二甲基-γ-羟基戊酸(β-甲基-γ-羟基亮氨酸)的内酯1的合成:1)由丙二酸钠和三甲基乙烯的环氧化物3,通过溴化α-α-羧基-β-甲基-γ-羟基-异己酸内酯(4B)和溴被氨基取代;2)从4B开始,Hn 3 /浓.硫酸; 3)通过亚硝基化将异丙烯基溴化镁加成到亚乙基丙二酸酯中,通过乙酰化还原α-肟基酯和酸水解得到的3,4-二甲基-2-乙氧基羰基-戊烯乙酯(4)乙酯(23A)制得乙酯(23A). 2-乙酰氨基-3,4-二甲基戊烯酸乙酯(4)酯(26).-酯26也是α-氨基-β.γ-二甲基-γ.δ-二羟基戊酸(β-甲基-γ.δ-二羟基亮氨酸)内酯2的原料:通过向26和ag中添加溴⊕-获得了辅助的硫酸水解2.通过异戊烯基乙酰氨基马来酸酯9可以进行另一种产率较低的26合成.还描述了根据erlenmeyer合成原理达到内酯2的尝试.-化合物1和2与γ-Amanitin和α-Aman
Doi:10.1002/jlac.19667000117

专利信息

专利号:US-6800785-B1
优先权日:2002-10-15
标题:Process for the synthesis of estrogen receptor modulators
发明人：MENG DONGFANG
权利人:MERCK & CO INC
摘要:The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone.

专利号:US-8580975-B2
优先权日:2008-01-11
标 题:Synthesis of macrocyclic cancer chemotherapy agents and methods of use
发明人：GHOSH ARUN K; XU XIAOMING
权利人:GHOSH ARUN K; XU XIAOMING; PURDUE RESEARCH FOUNDATION
摘要:Herein are described a process for forming a quaternary carbon useful in the preparation of macrolactones, an enantioselective synthesis of (+)-peloruside A, and methods for treating a patient in need of relief from cancer or a cancer-related disease. The described processes are useful for preparing compounds containing quaternary carbons, including structural analogs and derivatives of peloruside A.

专利号:US-11708341-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
发明人：Beaver Matthew; CUI SHENG; SHI XIANGQING
权利人:AMGEN INC
摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

专利号:US-9968612-B2
优先权日:2012-09-17
标题:Method of synthesizing thyroid hormone analogs and polymorphs thereof
发明人：TAUB REBECCA; REYNOLDS CHARLES H
权利人:MADRIGAL PHARMACEUTICALS INC
摘要:The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TRβ mutation.

专利号:US-2005256324-A1
优先权日:2004-05-10
标 题:Synthesis of amino acid keto-epoxides
发明人：LAIDIG GUY J; RADEL PEGGY A; SMYTH MARK S
权利人:PROTEOLIX INC
摘要:This invention relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.

专利号:WO-2018100050-A1
优先权日:2016-12-01
标 题 :Process for the preparation of an intermediate for the synthesis of carfilzomib
发明人：PASTÓ AGUILÀ Mireia; ÉCIJA QUERALT MARTA
权利人:ENANTIA S L
摘要:The present invention provides a compound which is the trichloroacetic acid salt of a compound of Formula (II) wherein R is selected from the group consisting of H, CH 3- , (CH 3 ) 2 CH-, (CH 3 ) 2 CHCH 2 -, CH 3 CH 2 CH(CH 3 )-, and PhCH 2 -, and a process for its preparation. Formula (II) Also provided is a process for its preparation based on the stereoselective epoxidation of the corresponding olefin precursor and a process for the preparation of several pharmaceutically active ingredients comprising the preparation of the compound of formula (II).