CAS: 1138-56-3; 4-Butoxybenzene-1-Sulfonyl Chloride

该化合物是一种主要用作有机合成中间体的专用的氯氟化碳衍生物,其丁氧替代成分可提高有机溶剂的溶性,有利于诸如磺酰胺形成,致癌和其他核生殖替代物等反应.该化合物具有反应性和选择性,可以将其引入目标分子,从而在制药和农用化学应用中发挥作用.在受管制条件下,其稳定性可确保合成工作流程的一贯性.需要妥善处理,因为其湿度敏感度和对核糖类的潜在再活动.该产品通常以高纯度供应,以满足严格的合成需求.

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1132-17-8 58076-33-8 58076-32-7

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上下游产品

CAS号352209-87-1 sodium 4-butoxy... | CAS号1126-79-0 丁基苯基醚 | CAS号139-02-6 苯酚钠 | CAS号825-90-1 4-羟基苯磺酸钠 | CAS号105411-89-0 1-(4-butoxyphen... | CAS号105411-94-7 5-bromo-1-(4-bu... | CAS号128887-36-5 1-(4-butoxy-3-n... | CAS号1138-58-5 4-(N-丁氧基)苯磺酰胺

合成工艺路线路线简述

    📜Sodium P-Hydroxybenzenesulfonate置于氯化亚砜,N,N-二甲基甲酰胺,Sodium Hydroxide体系中,用 二氯甲烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 24.0H,反应生成4-正丁氧基苯磺酰氯
    参考文献:Design And Bio-Evaluation Of Indole Derivatives As Potent Kv1.5 Inhibitors
    标题:Design And Bio-Evaluation Of Indole Derivatives As Potent Kv1.5 Inhibitors
    摘要:Atrial Fibrillation (Af) Is One Of The Common Arrhythmias That Threaten Human Health. Kv1.5 Potassium Channel Is Reported As An Efficacious And Safe Target For The Treatment Of Af. In This Paper,We Designed And Synthesized Three Series Of Compounds Through Modifying The Lead Compound Rh01617 That Was Screened Out By The Pharmacophore Model We Reported Earlier. All Of The Compounds Were Evaluated By The Whole-Patch Lamp Technology And Most Of Them Possessed Potent Inhibitory Activities Against Kv1.5. Compounds Iiii And Iiil Were Evaluated For The Target Selectivity As Well As The Pharmacodynamic Effects In An Isolated Rat Model. Due To The Promising Pharmacological Behavior,Compound Iiil Deserves Further Pharmacodynamic And Pharmacokinetic Evaluations. (C) 2013 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmc.2013.08.041

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    专利信息


    专利号:WO-2010039911-A1
    优先权日:2008-10-01
    标题 :Calcilytic compounds
    发明人：JEONG JAE U; MARQUIS ROBERT W JR
    权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR
    摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

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    合成参考文献

    参考DOI号:10.1016/j.bmc.2013.08.041
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