CAS: 1138-56-3; 4-Butoxybenzene-1-Sulfonyl Chloride

该化合物是一种主要用作有机合成中间体的专用的氯氟化碳衍生物,其丁氧替代成分可提高有机溶剂的溶性,有利于诸如磺酰胺形成,致癌和其他核生殖替代物等反应.该化合物具有反应性和选择性,可以将其引入目标分子,从而在制药和农用化学应用中发挥作用.在受管制条件下,其稳定性可确保合成工作流程的一贯性.需要妥善处理,因为其湿度敏感度和对核糖类的潜在再活动.该产品通常以高纯度供应,以满足严格的合成需求.

英文名称4-Butoxybenzene-1-Sulfonyl Chloride
中文名称4-丁氧基苯磺酰氯
IUPAC名称4-butoxybenzenesulfonyl chloride
其它别名4-(N-丁氧基)苯磺酰基氯; 4-N-Butoxybenzenesulfonyl Chloride
CAS编号1138-56-3
MFCD编号:MFCD00052344
EINECS号:601-287-0
分子式:C10H13ClO3S
分子量:248.73
产品CID: 170982
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: HGKWMUBXVMFXNC-UHFFFAOYSA-N
InChI=1S/C10H13ClO3S/c1-2-3-8-14-9-4-6-10(7-5-9)15(11,12)13/h4-7H,2-3,8H2,1H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数5.0

相似化合物

1132-17-8 58076-33-8 58076-32-7

MSDS等安全信息

GHS象形图
GHS符号GHS07 & GHS05;
注释: Exclamation mark & Corrosion
危险类别急性毒性类别4(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀类别1B
金属腐蚀物类别1
严重眼损伤类别1
皮肤致敏类别1
警示词Danger(危险)
危险描述H302 |吞咽有害.
H335 |可能引起呼吸道刺激.
H314 |造成严重皮肤灼伤和眼损伤.
H290 |可能对金属造成腐蚀.
H318 |造成严重眼损伤.
H317 |可能引起皮肤过敏反应.
防范说明P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
危险等级8
UN编号1759.0
危险品标志C
风险等级Corrosive
包装等级Ⅱ
安全声明26-36/37/39-45
危险类别码34

欧盟法规

C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

Sodium P-Hydroxybenzenesulfonate置于氯化亚砜,N,N-二甲基甲酰胺,Sodium Hydroxide体系中,用二氯甲烷,N,N-二甲基甲酰胺用作溶剂,化学反应 24.0H,反应生成4-正丁氧基苯磺酰氯
参考文献:Design And Bio-Evaluation Of Indole Derivatives As Potent Kv1.5 Inhibitors
标题:Design And Bio-Evaluation Of Indole Derivatives As Potent Kv1.5 Inhibitors
摘要:Atrial Fibrillation (Af) Is One Of The Common Arrhythmias That Threaten Human Health. Kv1.5 Potassium Channel Is Reported As An Efficacious And Safe Target For The Treatment Of Af. In This Paper,We Designed And Synthesized Three Series Of Compounds Through Modifying The Lead Compound Rh01617 That Was Screened Out By The Pharmacophore Model We Reported Earlier. All Of The Compounds Were Evaluated By The Whole-Patch Lamp Technology And Most Of Them Possessed Potent Inhibitory Activities Against Kv1.5. Compounds Iiii And Iiil Were Evaluated For The Target Selectivity As Well As The Pharmacodynamic Effects In An Isolated Rat Model. Due To The Promising Pharmacological Behavior,Compound Iiil Deserves Further Pharmacodynamic And Pharmacokinetic Evaluations. (C) 2013 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmc.2013.08.041

海关参考信息

2905121000-正丙醇
2905130000-正丁醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:WO-2010039911-A1
优先权日:2008-10-01
标题 :Calcilytic compounds
发明人：JEONG JAE U; MARQUIS ROBERT W JR
权利人:GLAXOSMITHKLINE LLC; JEONG JAE U; MARQUIS ROBERT W JR
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.