CAS: 113020-21-6; 1-(Methoxycarbonyl)Cyclopropanecarboxylic Acid

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CAS号6914-71-2 1,1-环丙烷二甲酸二甲酯 | CAS号67-56-1 甲醇 | CAS号1559-02-0 1,1-环丙基二羧酸二乙酯 | CAS号849217-48-7 1-(4-氟苯基氨基甲酰基)环丙烷羧酸 | CAS号113020-22-7 2-methoxycarbon... | CAS号88157-41-9 1-甲酰基环丙烷-1-羧酸甲酯 | CAS号88157-42-0 1-(羟甲基)环丙烷甲酸甲酯

1,1-环丙烷二甲酸二甲酯置于水,Lithium Hydroxide体系中,用 甲醇 用作溶剂,化学反应 1.0H,反应生成1,1-环丙基二甲酸单甲酯
参考文献:[1,4]二恶英[2,3-F]喹唑啉衍生物作为c-Met和vegfr-2的双重抑制剂的合成及其抗肿瘤活性.
标题:[1,4]二恶英[2,3-F]喹唑啉衍生物作为c-Met和vegfr-2的双重抑制剂的合成及其抗肿瘤活性.
摘要:C-Met和vegfr-2都是癌症治疗的重要靶标.为了开发可逆的和非共价的c-Met和vegfr-2双重抑制剂,设计并合成了一系列[1,4]二恶英[2,3-F]喹唑啉衍生物.酶分析表明,大多数目标化合物对c-Met和vegfr-2均具有抑制作用,Ic50值在纳摩尔范围内,尤其是化合物7M和7K.基于进一步的体外细胞增殖测定,化合物7K在体内对肝细胞癌(mhcc97H细胞)异种移植小鼠模型具有明显的抗肿瘤活性.我们将化合物7M与c-Met和vegfr-2激酶对接,并解释了这些类似物的sar.所有结果表明目标化合物是c-Met和vegfr-2激酶的双重抑制剂,在癌症治疗中具有广阔的发展前景.
Doi:10.1016/j.Bioorg.2019.04.010

专利信息

专利号:US-9676783-B2
优先权日:2008-10-22
标 题:Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds
发明人：HAAS JULIA; ANDREWS STEVEN W; JIANG YUTONG; ZHANG GAN
权利人:ARRAY BIOPHARMA INC
摘要:Compounds useful in the synthesis of compounds for treating pain, cancer, inflammation, neurodegenerative disease or Typanosoma cruzi infection in a mammal.

专利号:EP-2725028-A1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:EP-2725028-B1
优先权日:2008-10-22
标题 :Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:HU-E030413-T2
优先权日:2008-10-22
标 题:Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors

专利号:ES-2588504-T3
优先权日:2008-10-22
标题 :Pyrazolo [1,5-a] pyrimidine compounds substituted as intermediates in the synthesis of TRK kinase inhibitors

专利号:US-7737166-B2
优先权日:2005-08-17
标 题:Antifungal bicyclic hetero ring compounds
发明人：KAWAKAMI KATSUHIRO; KANAI KAZUO; HORIUCHI TAKAO; TAKESHITA HIROSHI; KOBAYASHI SYOZO; SUGIMOTO YUICHI; ACHIWA ISSEI; KUROYANAGI JUNICHI
权利人:DAIICHI SANKYO CO LTD
摘要:A 1,6-β-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-β-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate: