CAS: 1092364-38-9; 1-(4-((4-((3,4-Dichloro-2-Fluorophenyl)Amino)-7-Methoxyquinazolin-6-yl)Oxy)Piperidin-1-yl)Prop-2-En-1-One

上下游产品

4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol 1-acryloylpiperidin-4-yl 4-methylbenzenesulfonate 1-(3-chloropropanoyl)piperidin-4-yl 4-methylbenzenesulfonate 6-acetoxy-7-methoxy-3,4-dihydroquinazolin-4-one1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydr°Chloride

📜3,4-二氯-2-氟苯胺置于氨,Potassium Carbonate,N,N-二异丙基乙胺,三氯氧磷体系中,用 甲醇,N,N-二甲基乙酰胺,甲苯 用作溶剂,化学反应 29.33H,反应生成波齐替尼
参考文献: Method For Preparing 1-(4-(4-(3,4-Dichloro-2-Fluorophenylamino)-7-Methoxyquinazolin-6-Yloxy)Piperidin-1-yl)Prop-2-En-1-One[fr] Procédé De Préparation De 1-(4-(4-(3,4-Dichloro-2-Fluorophénylamino)-7-Méthoxyquinazolin-6-Yloxy)Pipéridin-1-yl)Prop-2-én-1-One
标题: Method For Preparing 1-(4-(4-(3,4-Dichloro-2-Fluorophenylamino)-7-Methoxyquinazolin-6-Yloxy)Piperidin-1-yl)Prop-2-En-1-One[fr] Procédé De Préparation De 1-(4-(4-(3,4-Dichloro-2-Fluorophénylamino)-7-Méthoxyquinazolin-6-Yloxy)Pipéridin-1-yl)Prop-2-én-1-One
摘要:本发明涉及一种新型制备1-(4-(4-(3,4-二氯-2-氟苯胺基)-7-甲氧基喹唑啉-6-氧基)哌啶-1-基)丙-2-烯-1-酮的方法,与传统方法相比,通过允许4-(3,4-二氯-2-氟苯胺基)-7-甲氧基喹唑啉-6-醇与n-酰基哌啶衍生物在惰性极性质子溶剂中在碱的存在下反应,实现了更简单的工艺过程.

专利信息

专利号:US-2022064145-A1
优先权日:2020-08-28
标 题 :Synthesis of poziotinib derivative
发明人：BANG KEUK CHAN; MOON YOUNG HO; CHANG YOUNG KIL
权利人:HANMI SCIENCE CO LTD
摘要:A method for the synthesis of a compound of Formula II is provided. Also disclosed is the salt form of the compound. The method includes the introduction of a piperidinyl moiety in a polar aprotic solvent system, followed by the removal of the protecting group and the acrylation step.

专利号:US-2021221792-A1
优先权日:2020-01-16
标题:Convergent synthesis of poziotinib derivative
发明人：CHAN BANG KEUK; HYUK JUNG JAE; HO MOON YOUNG
权利人:HANMI PHARM IND CO LTD
摘要:A method of for the synthesis of a compound of Formula I is disclosed herein. The method includes reacting a compound of formula (II) with a compound of formula (III) in an inert polar aprotic solvent system in the presence of a base.

专利号:US-11406709-B2
优先权日:2014-09-15
标 题 :Therapeutic and research application of PDCL3
发明人：RAHIMI NADER
权利人:UNIV BOSTON
摘要:Described herein are novel compositions comprising, for example, PDCL3 polypeptides having VEGFR-2 inhibitory activity, inhibitory PDCL3 antibodies and PDCL3-binding fragments thereof, or PDCL3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays a role, such as in carotid artery disease, macular degeneration, and plaque neovascularization. Also described herein are novel compositions comprising engineered PDCL3 polypeptides having enhanced chaperone activity, recombinant cells comprising such engineered PDCL3 polypeptides having enhanced chaperone activity, and methods thereof for therapeutic protein production and in vitro protein synthesis.

专利号:WO-2022043923-A1
优先权日:2020-08-28
标题 :Synthesis of poziotinib derivative