CAS: 10539-19-2; 1-Benzyl-3-Ethyl-6,7-Dimethoxyisoquinoline

相似化合物

1163-37-7 10172-49-3 482-76-8

📜3',4'-二甲氧基苯基苯乙酮置于silver Carbonate,Dichloro(Pentamethylcyclopentadienyl)Rhodium (III) Dimer,盐酸羟胺,Sodium Acetate,对甲苯磺酰肼,三甲基乙酸体系中,用 甲醇,乙醇,乙腈 用作溶剂,化学反应 31.0H,反应生成莫沙维林
参考文献:Rh(III)催化肟与烯烃的c-h活化/环化,用于区域选择性合成异喹啉†
标题:Rh(III)催化肟与烯烃的c-h活化/环化,用于区域选择性合成异喹啉†
摘要:已开发了一种rh(III)催化的肟和烯烃的c-h活化/环化反应,可容易地和区域选择性地接入异喹啉.该方案具有温和的反应条件和易于获得的起始原料,并已被用于莫西维林的简明合成.进行了动力学同位素效应研究,并提出了合理的机理.
Doi:10.1039/c6Ob00942E

专利信息

专利号:US-8933207-B2
优先权日:2010-07-28
标 题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C
权利人:CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C; SMARTCELLS INC
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk 1 , Alk 2 , and W are as defined and described herein.

专利号:US-2013131310-A1
优先权日:2010-07-28
标题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：KANE JOHN; LANCASTER THOMAS M; ZION TODD C
权利人:KANE JOHN; LANCASTER THOMAS M; ZION TODD C
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein each of X, Alk, and W are as defined and described herein.

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.