CAS: 95753-56-3; (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Aminophenyl)Propanoic Acid

• 英文名称(S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(4-Aminophenyl)Propanoic Acid
• 中文名称Fmoc-4-氨基-L-苯丙氨酸
• IUPAC名称(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-aminophenyl)propanoic acid
• 其它别名(S)-N-(9-Fluorenylmethyloxycarbonyl)-4-aminophenylalanine; Fm°C-4-Amino-Phe-OH
• CAS编号95753-56-3
• MFCD编号:MFCD00237664
• FDA UNII编号:KR3QK6R4XM
• 分子式:C24H22N2O4
• 分子量:402.44
• 产品CID: 2012124
• 产品分类有机原料→生命科学→氨基酸及其衍生物→苯丙氨酸及其衍生物

• 相似结构搜索
• InChIKey: VALNSJHHRPSUDO-QFIPXVFZSA-N
• VALNSJHHRPSUDO-QFIPXVFZSA-N…
• 计算化学: 氢键受体数4.0氢键供体数3可旋转键数6

相似化合物

物理性质

• 熔点190-205°C
• 沸点671.5°C at 760 mmHg
• 闪点359.9°C
• 密度1.3±0.1 g/cm3
• pKa:3.63±0.10(预测)
• PSA:101.65
• LogP:3.8032
• 折射率1.658
• 蒸汽压0.0±2.2 mmHg at 25°C
• 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
• 外观形态白色至淡黄色粉末
• 储存条件置于阴暗处,密封干燥,2-8°C

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险等级IRRITANT
• 危险品标志Xi

上下游产品

合成工艺路线路线简述

• 95753-55-2 = 95753-56-3
  反应条件:1.1 Reagents: Acetic Acid,Zinc Solvents: Ethanol; 5 H,60 °C
  标题:Chemistry For Dota Peptide Labeling At Phenylalanine Residues: On The Road To Preparing Peptide Ligand Tagged Libraries
  作者:De Leon-Rodriguez,Luis M.; Kovacs,Zoltan; Sherry,Alan D.
  参考文献:Letters In Organic Chemistry 日期:2005 卷标:2(2) 页码:160-164]
  
  95753-55-2 = 95753-56-3
  反应条件:1.1 Reagents: Acetic Acid,Hydrogen Catalysts: Palladium; Heated; 4 H,35 Psi
  标题:Pyridones As Src Family Sh2 Domain Inhibitors
  参考文献:World Intellectual Property Organization]
  
  220848-55-5 = 95753-56-3
  反应条件:1.1 Reagents: N-Methyl-2-Pyrrolidone,Bop Reagent; Rt1.2 Reagents: Acetic Acid,Tributylstannane Catalysts: Dichlorobis(Triphenylphosphine)Palladium Solvents: Dichloromethane; Rt
  标题:Focused Library Approach For Identification Of New N-Acylphenylalanines As Vcam/vla-4 Antagonists
  作者:Chen,Li; Trilles,Richard; Miklowski,Dorota; Huang,Tai-Nan; Fry,David; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2002 卷标:12(12) 页码:1679-1682]
  
  = 95753-56-3 [标题:Reaction Conditions
  标题:Two Novel Amino Acid Derivatives Containing Side-Chain Thioamides For The Synthesis Of Photoactivatable Peptides
  作者:Singh,Preeti; Hurrell,Craig R.; Findlay,John B. C.; Fishwick,Colin W. G.
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:1997 卷标:7(6) 页码:715-718]
  
  95753-55-2 = 95753-56-3
  反应条件:1.1 Reagents: Zinc,Hydrochloric Acid Solvents: Isopropanol,Water; Heated
  标题:Synthesis Of New Tetrazolyl Derivatives Of L- And D-Phenylalanine
  作者:Tolstyakov,V. V.; Tolstobrova,E. S.; Zarubina,O. S.; Popova,E. A.; Protas,A. V.; Et Al
  参考文献:Russian Journal Of Organic Chemistry 日期:2016 卷标:52(11) 页码:1681-1685]
  
  95753-55-2 = 95753-56-3
  反应条件:1.1 Reagents: Acetic Acid,Zinc Solvents: Ethanol; 24 H,60 °C
  标题:From Head To Tail: Microwave-Assisted Synthesis Of Para Hydrazine Nicotinamide Phenylalanine8-Oxytocin Derivatives
  作者:Miranda-Olvera,Alma D.; Espejel,Ignacio A. Rivero; De Leon Rodriguez,Luis M.
  参考文献:Letters In Organic Chemistry 日期:2007 卷标:4(4) 页码:261-264]
  
  174132-31-1 = 95753-56-3
  反应条件:1.1 Reagents: Trifluoroacetic Acid; 50 Min,Rt
  标题:Aromaticity And Amyloid Formation: Effect Of π-Electron Distribution And Aryl Substituent Geometry On The Self-Assembly Of Peptides Derived From Hiapp22-29
  作者:Profit,Adam A.; Vedad,Jayson; Saleh,Mohamad; Desamero,Ruel Z. B.
  参考文献:Archives Of Biochemistry And Biophysics 日期:2015 卷标:567 页码:46-58]
  
  = 95753-56-3 [标题:Reaction Conditions
  标题:α,α-Difluorophosphonomethyl Azobenzene Derivatives As Photo-Regulated Phosphoamino Acid Analogs. 1. Design And Synthesis
  作者:Park,Seung Bum; Standaert,Robert F.
  参考文献:Tetrahedron Letters 日期:1999 卷标:40(36) 页码:6557-6560]
  
  = 95753-56-3 [标题:Reaction Conditions
  标题:Site-Specific Incorporation Of Photoisomerizable Azobenzene Groups Into Ribonuclease S
  作者:Liu,David; Karanicolas,John; Yu,Catherine; Zhang,Zhihua; Woolley,G. Andrew
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:1997 卷标:7(20) 页码:2677-2680]
  
  = 95753-56-3 [标题:Reaction Conditions
  标题:Chiral Analysis Of The Reaction Stages In The Edman Method For Sequencing Peptides
  作者:Davies,John S.; Mohammed,A. Karim A.
  参考文献:Journal Of The Chemical Society 日期:1984 卷标:(10) 页码:1723-7

海关参考信息

• 2902600000-乙苯
  2905121000-正丙醇
  2912110000-甲醛
  2912120000-乙醛
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