CAS: 932-35-4; 3-Hydroxypicolinonitrile

该化合物是一种环形环状的环状环状氢氧化和硝三联有机化合物,具有氢和硝三联功能组,这种结构在合成应用中具有多种功能,特别是作为制药,农用化学品和协调化学的关键中间体. 氢氧化物组提高了溶性和再活性,而硝三联会则提供了通过核循环添加或循环化进一步功能化的处理器. 它的硬性丙烯核心有助于稳定,使其适合用于金属链状复合物或生物活性分子的前体. 化合物平衡的再活动特征和结构特征使得其在医药化学和材料科学方面的研究人员具有价值.

英文名称3-Hydroxypicolinonitrile
中文名称2-氰基-3-羟基吡啶
IUPAC名称3-hydroxypicolinonitrile
其它别名3-羟基皮考啉腈; 3-Hydroxypyridine-2-Carbonitrile
CAS编号932-35-4
MFCD编号:MFCD01646135
EINECS号:213-251-8
分子式:C6H4N2O
分子量:120.11
产品CID: 1970720
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: XTVFTOVNAKNVQK-UHFFFAOYSA-N
InChI=1S/C6H4N2O/c7-4-5-6(9)2-1-3-8-5/h1-3,9H…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数0.0

相似化合物

874-24-8 1849-55-4 933-90-4

MSDS等安全信息

GHS象形图
GHS符号GHS06;
注释: Skull and crossbones
危险类别急性毒性类别3(吸入)
急性毒性类别3(经皮)
急性毒性类别3(经口)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
警示词Danger(危险)
危险描述H331 |吸入会中毒.
H311 |皮肤接触会中毒.
H301 |吞咽会中毒.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P302+P352-P304+P340
危险等级6.1
UN编号3439.0
危险品标志T,Xi,Xn
包装等级Ⅲ
安全声明26-36/37/39-39
危险类别码20/21/22-36/37/38-41-37/38-22

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

3-hydroxypyridine N-oxide trimethylsilyl cyanide N,N-Dimethylcarbamoyl chloride 2-Formyl-3-hydroxypyridin (S)-4,5-dihydro-2-(3-hydroxy-2-pyridinyl)-4-methyl-4-thiazolecarboxylic acid 2-cyano-3-hydroxypyridine 1-oxide 2-aminomethyl-3-hydroxypyridine ethyl 3-aminofuro[3,2-b]pyridine-2-carboxylate

合成工艺路线路线简述

878194-93-5 = 932-35-4
反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Acetone,Water; Rt -> 0 °C1.2 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4); 0 - 8 °C; 20 Min,0 - 8 °C1.3 Reagents: Sodium Bisulfite Solvents: Water; 0 - 8 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; 0 - 8 °C
标题:Straightforward Access To Ethyl 3-Aminofuropyridine-2-Carboxylates From 1-Chloro-2-Cyano- Or 1-Hydroxy-2-Cyano-Substituted Pyridines
作者:Cailly,Thomas; Lemaitre,Stephane; Fabis,Frederic; Rault,Sylvain
参考文献:Synthesis 日期:2007 卷标:(20) 页码:3247-3251]

1849-55-4 = 932-35-4
反应条件:1.1 Reagents: Hydroxylamine-O-Sulfonic Acid Solvents: Diethyl Ether,Water
标题:Facile Synthesis Of Some Oxazolopyridines And Their N-Oxides Via Intramolecular Cyclization
作者:Tagawa,Yoshinobu; Goto,Yoshinobu
参考文献:Heterocycles 日期:1987 卷标:26(11) 页码:2921-39]

24026-94-6 = 932-35-4
反应条件:1.1 Reagents: Hydrochloric Acid,Bromine Solvents: Water; 0 °C; 1 H,0 °C; 0 °C -> Rt; 7 H,Rt1.2 Reagents: Sodium Hydroxide,Sodium Thiosulfate Solvents: Water; Ph 3
标题:Preparation Of Cyanopyridine Compounds From Furfural Derivatives By Cyanation,Oxidation,And Halogenation
参考文献:World Intellectual Property Organization]

6602-28-4 + 7677-24-9 = 932-35-4
反应条件:1.1 Reagents: Dimethylcarbamoyl Chloride Solvents: Dichloromethane; 0 °C; 16 H,Rt1.2 Reagents: Potassium Carbonate Solvents: Water; Ph 8,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 6,Rt
标题:Method For Synthesis Of 3-Hydroxy-2-Picolinic Acid And Derivatives Thereof From 3-Hydroxypyridine And Its Derivatives Via Oxidation,Cyanation And Hydrolysis
参考文献:China]

62626-61-3 = 932-35-4
反应条件:1.1 Reagents: Hydrochloric Acid,Chlorine
标题:Preparation Of Derivatives Of 3-Hydroxypicolinic Acid From Furfural
作者:Clauson-Kaas,Niels; Petersen,John Brammer; Soerensen,Georg Ole; Olsen,Gert; Janse,Gert
参考文献:Acta Chemica Scandinavica 日期:1965 卷标:19(5) 页码:1147-52]

= 932-35-4
反应条件:1.1 Reagents: Ammonium Acetate Solvents: Ethyl Acetate,Water; 5 Min,Rt -> 15 °C; 15 °C -> 22 °C; Overnight,22 °C
标题:Process For The Preparation Of 4-Alkoxy-3-Hydroxypicolinic Acids
参考文献:World Intellectual Property Organization]

1859081-50-7 = 932-35-4
反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Water; 20 - 30 Min,< 5 °C; 50 °C; 20 °C1.2 Reagents: Hydrogen Peroxide Solvents: Water; 20 Min,20 °C1.3 Reagents: Sodium Bisulfite Solvents: Water; 40 °C
标题:Process For The Preparation Of 4-Alkoxy-3-Hydroxypicolinic Acids Via Acetylation Of 4-Alkoxy-3-Acetoxypicolinic Acids Under Schotten-Baumann Reaction Conditions
参考文献:World Intellectual Property Organization]

1859081-50-7 = 932-35-4
反应条件:1.1 Reagents: Hydrogen Peroxide,Hydrogen Bromide Solvents: Water; 20 - 30 Min,< 5 °C; < 5 °C -> Rt; Rt -> 50 °C; 50 °C -> 20 °C; 20 Min,20 °C1.2 Reagents: Sodium Bisulfite Solvents: Water; 20 °C -> 40 °C; 45 Min,Cooled
标题:Process For The Preparation Of 4-Alkoxy-3-Hydroxypicolinic Acids
参考文献:World Intellectual Property Organization]

51315-07-2 = 932-35-4
反应条件:1.1 Reagents: Tetrabutylammonium Hydroxide Solvents: Tetrahydrofuran,Water; 1 H,23 °C
标题:Tetrabutylammonium Salt Induced Denitration Of Nitropyridines: Synthesis Of Fluoro-,Hydroxy-,And Methoxypyridines
作者:Kuduk,Scott D.; Dipardo,Robert M.; Bock,Mark G.
参考文献:Organic Letters 日期:2005 卷标:7(4) 页码:577-579]

62626-61-3 = 932-35-4
反应条件:1.1 Reagents: N-Bromosuccinimide,Hydrogen Bromide Solvents: Water; 8 H,Rt
标题:Preparation Of Pyran,Pyridine And Other Derivatives And Compositions With Them For Inhibiting Influenza Rna Polymerase Pa Subunit Endonuclease
参考文献:United States]

6602-28-4 + 7677-24-9 = 932-35-4 [标题:Reaction Conditions
标题:Introduction Of The Cyano Group By Substitution Of Hydrogen
作者:Schmidt,A.
参考文献:Science Of Synthesis 日期:2004 卷标:19 页码:133-161]

6602-28-4 = 932-35-4 [标题:Reaction Conditions
标题:Preparation Of Desmethyldesferrithiocin Derivatives And Related Compounds As Iron-Chelating Antimalarials.
参考文献:World Intellectual Property Organization]

= 932-35-4 [标题:Reaction Conditions
标题:Regioselective Cyanation Of 3-Substituted Pyridine 1-Oxides
作者:Fife,Wilmer K.
参考文献:Heterocycles 日期:1984 卷标:22(1) 页码:93-6]

= 932-35-4 [标题:Reaction Conditions
标题:Trimethylsilanol As A Leaving Group; Iii. A Simple One-Step Conversion Of Aromatic Heterocyclic N-Oxides To α-Cyano Aromatic N-Heterocycles
作者:Vorbrueggen,Helmut; Krolikiewicz,Konrad
参考文献:Synthesis 日期:1983 卷标:(4) 页码:316-19]

= 932-35-4 [标题:Reaction Conditions
标题:Mercaptopyridinecarboxylic Acids. Synthesis And Hypoglycemic Activity
作者:Blank,Benjamin; Ditullio,Nicholas W.; Miao,Clara K.; Owings,Franklin F.; Gleason,John G.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1974 卷标:17(10) 页码:1065-71

3-羟基-2-吡啶甲醛置于碳酸氢钠,Hydroxylamine-O-Sulfonic Acid体系中,用乙醚,水作为反应溶剂,化学反应 5.0H,以86%的收率获得产物2-氰基-3-羟基吡啶
参考文献:Tagawa,Yoshinobu; Goto,Yoshinobu,Heterocycles,1987,Vol. 26,# 11,P. 2921-2939
标题:Tagawa,Yoshinobu; Goto,Yoshinobu,Heterocycles,1987,Vol. 26,# 11,P. 2921-2939

海关参考信息

2933310010-吡啶
2926909090-其他腈基化合物
2905199090-其他饱和一元醇
2939800000-其他生物碱
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2009118512-A1
优先权日:2006-03-31
标题:Process for Preparing 6,7-Dihydro-5H-Imidazo[1,5-A]Pyridin-8-One
发明人：MARTIN PIERRE; BOUDIER ANDREAS; QUIRMBACH MICHAEL; MAH ROBERT; JOTTERAND NATHALIE
权利人:MARTIN PIERRE; BOUDIER ANDREAS; QUIRMBACH MICHAEL; MAH ROBERT; JOTTERAND NATHALIE
摘要:6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deprotection of the imidazole and deprotection of the alcohol functionality; 3) a process which proceeds from 5,6,7,8-tetrahydroimidazo[1,5-a]pyridine [38666-30-7], which is oxidized.

专利号:WO-2017156194-A1
优先权日:2016-03-08
标题:Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
发明人：PUERTA DAVID T; COHEN SETH M; CREDILLE CY V
权利人:UNIV CALIFORNIA; PUERTA DAVID T
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

专利号:US-10889556-B2
优先权日:2016-03-08
标题 :Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease
发明人：COHEN SETH M; CREDILLE CY V; PUERTA DAVID T
权利人:UNIV CALIFORNIA
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:CN-118978522-A
优先权日:2024-08-05
标题 :Synthesis method of 2-substituted-4-hydroxy-2-thiazoline derivative