CAS: 90407-14-0; 7-Chlorobenzo[b]Thiophene

该化合物是一种该化合物是一种苯并[b]thiophene核心,在7位位置被氯原子取代.这种结构具有独特的反应性,使其成为有机合成中的宝贵中间体,特别是在制药和农用化学中.氯代谢会增强电益特性,通过交叉交织或核循环替代反应促进进一步的功能化.它的芳香色硫苯环有助于稳定,同时允许参与多种化学转化.该化合物通常用于生物活性分子的开发,包括动脉抑制剂和抗微生物剂.高纯度可用于确保研究和工业应用的一致性能.由于潜在的再活动危害,建议进行适当的处理.

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1,2-dichloro-benzene ethanethiol acetylene 6-hepten-1-ol 4-chlorobutylmagnesium bromide allyl bromide 4-chlorobutyl bromide (S)-2-cyclopentyloxycarbonyl-amino-8-nonenoic acid (R)-2-acetamido-8-nonenoic acid (+/-)-2-acetamido-8-nonenoic acid

合成工艺路线路线简述

  • 合成目标产物 7-Chloro-Benzo[b]Thiophene 主要起始原料 (2-Chlorophenyl)(2,2-Diethoxyethyl)Sulfane
  • 90407-13-9 = 90407-14-0
    反应条件:1.1 Reagents: Hydrochloric Acid,Water Solvents: Ethanol,Water
    标题:7-Substituted Benzo[b]Thiophenes And 1,2-Benzisothiazoles. Part 2. Chloro And Nitro Derivatives
    作者:Rahman,Loay K. A.; Et Al
    参考文献:Journal Of The Chemical Society 日期:1984 卷标:(3) 页码:385-90]

    936902-05-5 = 90407-14-0
    反应条件:1.1 Catalysts: Phosphoric Acid Solvents: Chlorobenzene; 12 H,130 °C
    标题:Direct Construction Of 2,3-Unsubstituted Benzofurans And Benzothiophenes Via A Metal-Free Catalyzed Intramolecular Friedel-Crafts Reaction
    作者:Ma,Weimin; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2019 卷标:6(4) 页码:493-497]

    90407-16-2 = 90407-14-0 [标题:Reaction Conditions
    标题:7-Substituted Benzo[b]Thiophenes And 1,2-Benzisothiazoles. Part 2. Chloro And Nitro Derivatives
    作者:Rahman,Loay K. A.; Et Al
    参考文献:Journal Of The Chemical Society 日期:1984 卷标:(3) 页码:385-90]

    = 90407-14-0
    反应条件:1.1 Reagents: Hydrogen Sulfide
    标题:High-Temperature Organic Synthesis. Xlii. Reaction Of Haloarenes And 2-Chlorothiophene With Hydrogen Sulfide And Acetylene
    作者:Denyagina,E. N.; Et Al
    参考文献:Zhurnal Organicheskoi Khimii 日期:1993 卷标:29(11) 页码:2246-50]

    2032-35-1 + 6320-03-2 = 90407-14-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 1 H,60 °C1.2 6 H,Reflux2.1 Catalysts: Phosphoric Acid Solvents: Chlorobenzene; 12 H,130 °C
    标题:Direct Construction Of 2,3-Unsubstituted Benzofurans And Benzothiophenes Via A Metal-Free Catalyzed Intramolecular Friedel-Crafts Reaction
    作者:Ma,Weimin; Et Al
    参考文献:Organic Chemistry Frontiers 日期:2019 卷标:6(4) 页码:493-497]

    3260-86-4 = 90407-14-0
    反应条件:1.1 Reagents: Sodium Borohydride Solvents: Ethanol2.1 Reagents: Hydrochloric Acid,Water Solvents: Ethanol,Water
    标题:7-Substituted Benzo[b]Thiophenes And 1,2-Benzisothiazoles. Part 2. Chloro And Nitro Derivatives
    作者:Rahman,Loay K. A.; Et Al
    参考文献:Journal Of The Chemical Society 日期:1984 卷标:(3) 页码:385-90]

    90965-06-3 = 90407-14-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Methanol,Tetrahydrofuran; 20 Min,0 °C; 19 H,Rt
    标题:Unexpected Formation Of 4,7-Dihalobenzo[b]Thiophenes Using Ohira-Bestmann Reagent And Reactivity Of The Halogen-Substituted Benzo[b]Thiophenes In Suzuki-Miyaura Coupling With Phenylboronic Acid
    作者:Toyota,Kozo; Et Al
    参考文献:Heterocycles 日期:2019 卷标:98(10) 页码:1355-1374]

    85070-48-0 + 34301-54-7 = 90407-14-0
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 1.5 H,0 °C1.2 Solvents: Dimethylformamide; 2 H,-40 °C2.1 Reagents: Potassium Carbonate Solvents: Methanol,Tetrahydrofuran; 20 Min,0 °C; 19 H,Rt
    标题:Unexpected Formation Of 4,7-Dihalobenzo[b]Thiophenes Using Ohira-Bestmann Reagent And Reactivity Of The Halogen-Substituted Benzo[b]Thiophenes In Suzuki-Miyaura Coupling With Phenylboronic Acid
    作者:Toyota,Kozo; Et Al
    参考文献:Heterocycles 日期:2019 卷标:98(10) 页码:1355-1374
📜邻氯苯硫酚置于potassium Carbonate体系中,用 丙酮,甲苯 作为反应溶剂,化学反应 8.5H,反应生成 7-氯苯并噻吩
参考文献:New Analogs As Androgen Receptor And Glucocorticoid Receptor Modulators
标题:New Analogs As Androgen Receptor And Glucocorticoid Receptor Modulators
摘要:本发明涉及一种新型的二氢吡啶衍生物,其化学式为(I):作为选择的核受体调节剂,所述核受体包括雄激素受体和糖皮质激素受体,以及其制备方法,包括所述化合物的制药组合物和利用所述化合物制造用于治疗可以通过调节雄激素受体和/或糖皮质激素受体改善的病理情况或疾病的药物,所述病理情况或疾病包括癌症,转移性癌症,良性前列腺增生,多囊卵巢综合征(pcos),脱发,多毛症,痤疮,性腺功能减退,肌肉消耗性疾病,虚弱,库欣综合征,抗精神病药物诱导的体重增加,肥胖,创伤后应激障碍和酗酒.

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合成参考文献


参考文献:10.1007/s00894-007-0234-3
摘要:Khedkar SA, Malde AK, Coutinho EC. CoMFA study of distamycin analogs binding to the minor-groove of DNA: a unified model for broad-spectrum activity. Journal of Molecular Modeling. 2007 Aug 10;13(10):1099–108. doi: 10.1007/s00894-007-0234-3.
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