CAS: 89794-02-5; 4-Bromo-2-Chlorotoluene

上下游产品

CAS号95-49-8 邻氯甲苯 | CAS号106-38-7 对溴甲苯 | CAS号1707-04-6 Phosphonic acid... | CAS号59748-90-2 4-溴-2-氯苯甲酸 | CAS号89720-77-4 2-氯-4-溴溴苄 | CAS号515157-47-8 bis(3-chloro-4-... | CAS号515158-85-7 3-Chloro-4-Meth...

2-氯甲苯置于gold(Iii) Chloride,N-溴代丁二酰亚胺(Nbs),三氟化硼乙醚体系中,用 二氯甲烷 作为反应溶剂,化学反应 11.0H,以80%的收率获得产物4-溴-2-氯甲苯
参考文献:Gold-Catalyzed Halogenation Of Aromatics By N-Halosuccinimides
标题:Gold-Catalyzed Halogenation Of Aromatics By N-Halosuccinimides
摘要:
DOI:10.1002/anie.200906699

专利信息

专利号:US-5922866-A
优先权日:1995-08-30
标题:Process for preparing quinazolin-4-one derivatives
发明人：MIYATA KAZUYOSHI; KUROGI YASUHISA; SAKAI YASUHIRO; TSUDA YOSHIHIKO
权利人:OTSUKA PHARMA CO LTD
摘要:The present invention provides a novel process for preparing a series of quinazolin-4-one derivatives in high yields with reduced amounts of byproducts, the process comprising reacting, in the presence of a base, a trialkylsilyl halide with a compound represented by the formula ##STR1## wherein; R 5 is a phenyl group which may have 1 to 3 substituents each selected from a lower alkyl group, a lower alkoxy group or a halogen atom, a lower alkyl group, a phenyl-lower alkyl group which may have a halogen atom as a substituent on the phenyl ring, a lower alkenyl group, a lower alkoxy-lower alkyl group or a lower alkynyl group; R 6 is a lower alkyl group, a halogen-substituted lower alkyl group, a lower alkoxycarbonyl group or a phenyl group which may have, as a substituent, a lower alkyl group or a group of the formula ##STR2## wherein A is an oxygen atom or a single bond, Z is a lower alkylene group, R 7 is a lower alkyl group and R 8 is a lower alkoxy group, a phenyl group or a phenyl-lower alkoxy group which may have a halogen atom on the phenyl ring; n to produce the quinazolin-4-one derivatives which is valuable as pharmaceuticals or intermediates for synthesis thereof and represented by the formula ##STR3## wherein R 1 ,R 2 , R 3 , R 4 , R 5 , and R 6 are as defined above.