CAS: 871231-45-7; Potassium Trifluoro(3-Hydroxyphenyl)Borate

上下游产品

CAS号626-02-8 3-碘苯酚 | CAS号591-20-8 3-溴苯酚 | CAS号87199-18-6 3-羟基苯硼酸 | CAS号1279123-63-5 potassium hydro... | CAS号13675-18-8 四羟基二硼烷 | CAS号108-43-0 3-氯酚 | CAS号1017601-66-9 1-苄基-5-(3-羟基苯基)...

📜3-碘苯酚置于叔丁基锂,硼酸三异丙酯,Potassium Hydrogen Difluoride体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 1.0H,以98%的收率获得产物3-羟基苯基三氟硼酸钾
参考文献:A Facile One-Pot Preparation Of Potassium Hydroxyaryl-And (Hydroxyalkyl)Aryltrifluoroborates
标题:A Facile One-Pot Preparation Of Potassium Hydroxyaryl-And (Hydroxyalkyl)Aryltrifluoroborates
摘要:Potassium Hydroxyaryl-And (Hydroxyalkyl)Aryltrifluoroborates Have Been Prepared In A Simple One-Pot Process From The Corresponding Hydroxy-Substituted Aryl Halides In 51-98% Yields Through An In Situ Protection Of The Free Hydroxyl Group With T-Buli. Also,We Successfully Performed A Microwave-Promoted Suzuki-Miyaura Cross-Coupling Reaction Of These Substrates With Aryl-And Alkenyl Bromides In The Presence Of 0.5 Mol % Of Pd(Oac)(2) Catalyst Without Ligands.
DOI:10.1021/ol800083J

专利信息

专利号:US-8513465-B2
优先权日:2008-02-04
标题:Potassium organotrifluoroborate derivative and a production method therefor
发明人：KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE
权利人:KANG HEONJOONG; HAM JUNGYEOB; AHN HONG RYUL; PARK YOUNG HEE; SNU R&DB FOUNDATION
摘要:Provided are a production method for a potassium organotrifluoroborate compound having a hydroxyl group, and a novel potassium organotrifluoroborate compound having a hydroxyl group. The production method is advantageous in that a potassium organotrifluoroborate compound can be produced in a single reaction without recourse to a process of isolating and purifying an intermediate. The novel potassium organotrifluoroborate compound having a hydroxyl group is useful as a reactant which is widely used in the total synthesis of physiologically active natural products and diverse organic synthesis reactions including halogen substitution reactions, 1,2- and 1,4-addition reactions using a rhodium (Rh) catalyst, and Suzuki coupling reactions using a palladium (Pd) catalyst.