CAS: 84127-04-8; Bis(4-Methoxyphenyl)Phosphine

该化合物是一种有机磷磷磷化合物,其特点是磷原子与两个4-甲基苯基组相连接,这种化合物通常呈现无色的黄色外观,以其独特的气味而闻名,可与大蒜或鱼类相仿,在正常条件下相对稳定,但在有水分的情况下可能进行水解;甲基氧组的存在增强了有机溶剂的溶解性,使其在各种化学应用中有用,包括作为悬浮剂和协调化学及有机合成中的有机合成.此外,这种化合物可起到减少剂的作用,并参与各种催化过程.在处理这种物质时,应当注意安全防范,因为如果吸入或摄入这种物质,可能会对健康造成危害.

英文名称Bis(4-Methoxyphenyl)Phosphine
中文名称双(4-甲氧基苯基)膦
IUPAC名称bis(4-methoxyphenyl)phosphane
CAS编号84127-04-8
MFCD编号:MFCD15143653
EINECS号:686-979-0
分子式:C14H15O2P
分子量:246.24
产品CID: 1829710
产品分类有机原料 → 有机膦化合物

相似结构搜索
产品信息参考;
InChIKey: FWKICRREDMVWRF-UHFFFAOYSA-N
1S/C14H15O2P/c1-15-11-3-7-13(8-4-11)17-14-9-5-12(16-2)6-10-14/h3-10,17H,1-2H3…
计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数4.0

MSDS等安全信息

GHS象形图
GHS符号GHS02 & GHS07;
注释: Flame & Exclamation mark
危险类别易燃固体类别2
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H228 |易燃固体.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P210-P261-P305+P351+P338
危险等级4.1
UN编号1325
危险品标志F
包装等级Ⅱ
安全声明26-36
危险类别码11-36/37/38
WGK Germany3

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Tetrahydrofuran,Hexane; 15 Min,Rt; 30 Min,Rt1.2 Solvents: Tert-Butyl Methyl Ether; 10 Min,Rt; Rt -> 0 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 15 Min,0 °C1.4 Reagents: Sodium Chloride Solvents: Water; 5 Min,0 °C
标题:Selective Dehydrocoupling Of Phosphines By Lithium Chloride Carbenoids
作者:Molitor,Sebastian; Becker,Julia; Gessner,Viktoria H.
参考文献:Journal Of The American Chemical Society 日期:2014 卷标:136(44) 页码:15517-15520]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Tetrahydrofuran; Rt; 0.5 - 16 H,35 °C1.2 Reagents: Sodium Hydroxide Solvents: Tert-Butyl Methyl Ether,Water; 35 °C; 35 °C -> 0 °C; 15 Min,0 °C
标题:Facile,Catalytic Dehydrocoupling Of Phosphines Using β-Diketiminate Iron(Ii) Complexes
作者:King,Andrew K.; Buchard,Antoine; Mahon,Mary F.; Webster,Ruth L.
参考文献:Chemistry - A European Journal 日期:2015 卷标:21(45) 页码:15960-15963]

1069-08-5 + 13139-86-1 = 84127-04-8
反应条件:1.1 Reagents: Lithium Aluminum Hydride Solvents: Tetrahydrofuran1.2 Reagents: Hydrochloric Acid Solvents: Hexane1.3 Solvents: Diethyl Ether
标题:Electrophilic Trifluoromethylation - Approaches With Hypervalent Iodine Compounds
作者:Kieltsch,Iris
参考文献:2008]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Triethylamine,Trichlorosilane Solvents: Xylene; Rt; 100 °C; Reflux
标题:Electronic And Steric Effects Of Ligands As Control Elements For Rhodium-Catalyzed Asymmetric Hydrogenation
作者:Herseczki,Zsanett; Gergely,Ildiko; Hegedues,Csaba; Szoellosy,Aron; Bakos,Jozsef
参考文献:Tetrahedron: Asymmetry 日期:2004 卷标:15(11) 页码:1673-1676]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Pinacolborane Solvents: Acetonitrile; 20 H,60 °C1.2 Reagents: Isopropanol
标题:Rapid Metal-Free Formation Of Free Phosphines From Phosphine Oxides
作者:Provis-Evans,Cei B.; Emanuelsson,Emma A. C.; Webster,Ruth L.
参考文献:Advanced Synthesis & Catalysis 日期:2018 卷标:360(20) 页码:3999-4004]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Tetrahydrofuran; 40 Min,25 °C1.2 Solvents: Tert-Butyl Methyl Ether; 10 Min,Rt; 10 Min,Rt; 10 Min,Rt; Rt -> 5 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 20 Min
标题:A Superior Method For The Reduction Of Secondary Phosphine Oxides
作者:Busacca,Carl A.; Lorenz,Jon C.; Grinberg,Nelu; Haddad,Nizar; Hrapchak,Matt; Et Al
参考文献:Organic Letters 日期:2005 卷标:7(19) 页码:4277-4280]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Toluene,Tetrahydrofuran; 10 Min,Rt; 2 H,Rt1.2 Solvents: Tert-Butyl Methyl Ether; 5 Min,Rt; 10 Min,Rt; Rt -> 5 °C1.3 Reagents: Sodium Hydroxide Solvents: Water; 10 Min,5 °C
标题:Copper-Catalyzed C-P Cross-Coupling Of Secondary Phosphines With (Hetero)Aromatic Bromide
作者:Li,Chun-Jing; Lu,Jing; Zhang,Zhi-Xun; Zhou,Kun; Li,Yan; Et Al
参考文献:Research On Chemical Intermediates 日期:2018 卷标:44(7) 页码:4547-4562]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Tetrahydrofuran,Hexane; 15 Min,Rt; 3 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Diethyl Ether,Water; 15 Min,0 °C; 5 Min,0 °C
标题:Tailored Cobalt-Catalysts For Reductive Alkylation Of Anilines With Carboxylic Acids Under Mild Conditions
作者:Liu,Weiping; Sahoo,Basudev; Spannenberg,Anke; Junge,Kathrin; Beller,Matthias
参考文献:Angewandte Chemie 日期:2018 卷标:57(36) 页码:11673-11677]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Diisobutylaluminum Hydride Solvents: Tetrahydrofuran,Hexane; 15 Min,Rt; 4 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Diethyl Ether,Water; 15 Min,0 °C; 5 Min,Rt
标题:Manganese Catalyzed Urea And Polyurea Synthesis Using Methanol As C1 Source
作者:Guo,Jiaxin; Tang,Jun; Xi,Hui; Zhao,Sheng-Yin; Liu,Weiping
参考文献:Chinese Chemical Letters 日期:2023 卷标:34(4)]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Pinacolborane Solvents: Acetonitrile; 20 H,60 °C
标题:Hydrogen/halogen Exchange Of Phosphines For The Rapid Formation Of Cyclopolyphosphines
作者:Barrett,Adam N.; Woof,Callum R.; Goult,Christopher A.; Gasperini,Danila; Mahon,Mary F.; Et Al
参考文献:Inorganic Chemistry 日期:2021 卷标:60(21) 页码:16826-16833]

15754-51-5 = 84127-04-8
反应条件:1.1 Reagents: Phenylsilane Catalysts: Borinic Acid,B,B-Bis(2-Chlorophenyl)- Solvents: Toluene; 18 H,80 °C
标题:Metal-Free Reduction Of Phosphine Oxides,Sulfoxides,And N-Oxides With Hydrosilanes Using A Borinic Acid Precatalyst
作者:Chardon,Aurelien; Maubert,Orianne; Rouden,Jacques; Blanchet,Jerome
参考文献:Chemcatchem 日期:2017 卷标:9(24) 页码:4460-4464

氯二(4-甲氧苯基)膦置于lithium Aluminium Tetrahydride体系中,用乙醚作为反应溶剂,以85 %的收率获得产物双(4-甲氧基苯基)膦
参考文献: Diphosphine Compounds And Complexes[fr] Composés Et Complexes De Diphosphine
标题: Diphosphine Compounds And Complexes[fr] Composés Et Complexes De Diphosphine
摘要:A Diphosphine Precursor Compounds Of Formula (I),Conjugates Thereof Of Formula (II) And Radionuclide Conjugate Complexes Thereof Are Disclosed Herein. The Compounds Are Advantageous At Least Because They Enable The Easy One-Step Extemporaneous Preparation Of The Corresponding Complexes In The Clinic In High Radiochemical Yields And Under Mild Conditions. Also Disclosed Are The Methods Of Making The Compounds And Complexes Herein Along With Their Uses. The Complexes Are Particularly Useful In The Field Of Medicine And Diagnosis,Such As In Medical Imaging And Targeted Payload Delivery.

海关参考信息

2905110000-甲醇
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4985567-A
优先权日:1988-03-07
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO; TAKEDA HIDEO
权利人:KAZUO ACHIWA; FUJI YAKUHIN KOGYO KK
摘要:New chiral phosphinopyrrolidine compounds of the general formula: ##STR1## wherein R 1 is hydrogen or --COA 1 , --COOA 2 , --CONHA 3 , --SO 2 A 4 or --PO(A 5 ) 2 , A 1 , A 2 , A 3 , A 4 and A 5 each represents independently alkyl or aryl, R 2 is phenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, and R 3 is phenyl, lower-alkylphenyl, di(lower-alkyl)aminophenyl, lower-alkoxyphenyl or 3,5-dimethyl-4-methoxyphenyl, with the proviso that R 2 and R 3 may not simultaneously by phenyl, p-di(lower-alkyl)-aminophenyl or p-lower-alkoxyphenyl, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-12291489-B2
优先权日:2016-07-01
标题 :Synthesis of nanocomposites and their use in enhancing plant nutrition
发明人：BISWAS PRATIM; RALIYA RAMESH
权利人:BISWAS PRATIM; RALIYA RAMESH; WASHINGTON UNIVERSITY ST LOUIS
摘要:The present disclosure is related to the development of improved fertilizer for precision and sustainable agriculture. A method was developed wherein efficient NPK nanocomposite for plant nutrition was synthesized in a single step using aerosol science and technology concepts. Further a formulation was prepared by addition of ZnO, TiO 2 and other nanoparticles to the NPK nanocomposite. Also, an aerosol based foliar application technique was developed for the precise delivery of nanoparticles to the plants.

专利号:WO-2025096445-A1
优先权日:2023-10-30
标题:Synthesis of intermediates for the preparation of macrocyclic compounds
发明人：CHOI YOUNGGI; HUYNH HOAN
权利人:ALKERMES INC
摘要:Provided are methods for synthesizing intermediates useful in the preparation of compounds having activity against orexin-2 receptor.

专利号:US-2019202750-A1
优先权日:2016-07-01
标题 :Synthesis of nanocomposites and their use in enhancing plant nutrition

专利号:ES-2404827-T3
优先权日:2008-12-18
标题:Procedure for the synthesis of aminomethyl-tetralin derivatives

专利号:US-9062085-B2
优先权日:2010-09-10
标题 :Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis
发明人：ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO
权利人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO; KANATA CHEMICAL TECHNOLOGIES INC
摘要:The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B))