CAS: 74431-23-5; (5R,6S)-3-((2-Formimidamidoethyl)Thio)-6-((R)-1-Hydroxyethyl)-7-Oxo-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylic Acid Hydrate

相似化合物

85604-01-9 59995-64-1 92309-29-0

Imipenem置于二氯甲烷,异丙醇体系中,用 二氯甲烷 作为反应溶剂,化学反应 4.0H,以obtained At Step (D) Example 1的收率获得产物亚胺培南(一水物)
参考文献:Process For The Isolation Of Crystalline Imipenem
标题:Process For The Isolation Of Crystalline Imipenem
摘要:本发明涉及一种成本效益和工业优势的高纯度亚胺培南制备过程,其包括以下步骤:用有机溶剂处理含有亚胺培南的水溶液,其中亚胺培南没有经过冻干;从反应混合物中分离出纯结晶的亚胺培南单水合物.

专利信息

专利号:US-5145957-A
优先权日:1988-03-18
标 题:Stereoselective synthesis of a chiral cis 3-beta hydrogen (3R) 4-aroyloxy azetidinone
发明人：TSCHAEN DAVID M; LYNCH JOSEPH E; LASWELL WILLIAM L; VOLANTE RALPH P; SHINKAI ICHIRO
权利人:MERCK & CO INC
摘要:A process is described for the stereocontrolled synthesis of (3R,4R)-3-[(1R)-1-hydroxyethyl]-4-benzoyloxyazetidin-2-ones and their derivatives by cycloaddition involving an imine and a ketone, generated from 3(S)-hydroxybutyrate which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:US-11999757-B2
优先权日:2017-11-01
标 题:Synthesis of boronate ester derivatives and uses thereof
发明人：BOYER SERGE HENRI; HECKER SCOTT J; VERZIJL GERARDUS K M; HERMSEN PETRUS J
权利人:MELINTA SUBSIDIARY CORP
摘要:Disclosed herein are methods for the preparation of boronate derivatives in the synthesis of antimicrobial compounds and uses thereof. Disclosed herein includes method of making a compound of Formula (B) by reducing the ketone group of the keto-ester compound of Formula (A), and the reduction can be performed using a Ruthenium based catalyst system or using an alcohol dehydrogenase bioreduction system.

专利号:EP-0269236-B1
优先权日:1986-10-24
标题:Process for synthesis of a chiral azetidinone
摘要:A process is described for the stereo-controlled synthesis of 3-(R)-3-[1'-(R)-hydroxyethyl]-4-(R)-benzoyl-2-oxo-1-aze tidines and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:EP-0343716-A1
优先权日:1988-05-23
标 题 :Process for synthesis of a beta-lactam carbapenem intermediate
发明人：LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonyl­methyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.

专利号:US-5037974-A
优先权日:1988-05-23
标题:Cyclization process for synthesis of a beta-lactam carbapenem intermediate
发明人：LOEWE MALLORY F; CVETOVICH RAYMOND; HAZEN GEORGE G
权利人:MERCK & CO INC
摘要:A process is described for the synthesis of 3(S)-4(R)-3-[1(S)-hydroxyethyl]-4-(alkoxycarbonylmethyl)-azetidin-2-one (II) which is a useful intermediate in the synthesis of carbapenem antibiotics.