专利号:WO-2009116057-A2 优先权日:2008-03-18 标 题:A process for the synthesis of alpha-olefin polymerization procatalysts
专利号:US-9175357-B2 优先权日:2011-02-04 标 题:Fragment ligated inhibitors selective for the polo box domain of PLK1 发明人:MCINNES CAMPBELL; FARAG DOAA BOSHRA 权利人:MCINNES CAMPBELL; FARAG DOAA BOSHRA; UNIV SOUTH CAROLINA 摘要:Methods for developing non-peptidic inhibitors that target the polo-box domain of PLK1 proteins are described. Methods include developing structure activity relationships for peptidic inhibitors followed by development of non-peptide fragment alternatives for portions of the peptide inhibitors. The non-peptide fragment can provide similar structure activity relationship as the replaced peptide. Fragment alternatives to key binding determinants are identified in an iterative computational and synthetic process facilitated through understanding of the peptide structure-activity relationships. The approach is informed by peptide structure-activity data obtained through synthesis and testing of truncated and mutated analogs of known PBD binding motifs.
专利号:EP-2257576-A2 优先权日:2008-03-18 标题:A process for the synthesis of alpha-olefin polymerization procatalysts
专利号:EP-2257576-B1 优先权日:2008-03-18 标 题 :A process for the synthesis of alpha-olefin polymerization procatalysts
专利号:RU-2038844-C1 优先权日:1990-05-04 标 题:Catalytic composition for ethylene oxide hydroformylation, method of its preparing and a method of synthesis of 1,3-propanediol and 3-hydroxypropionic aldehyde
专利号:CN-113105408-B 优先权日:2021-04-12 标 题:A novel asymmetric catalytic nucleophilic fluoroheterocyclization reaction system and its application in the synthesis of chiral unnatural amino acid modules