专利号:US-9034844-B2 优先权日:2009-04-06 标 题 :6′-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides 发明人:TAMERLANI GIANCARLO; LOMBARDI ILARIA; BARTALUCCI DEBORA; DANESI ANDREA; SALSINI LIANA; MANONI MARCO; CIPOLLETTI GIOVANNI 权利人:TAMERLANI GIANCARLO; LOMBARDI ILARIA; BARTALUCCI DEBORA; DANESI ANDREA; SALSINI LIANA; MANONI MARCO; CIPOLLETTI GIOVANNI; INALCO SPA 摘要:The present invention relates to a process of synthesis of α-sialyl oligosaccharides and in particular of 6′-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.
专利号:US-10973847-B2 优先权日:2017-06-30 标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof 发明人:JOHNSON JEREMIAH A; GOLDER MATTHEW R 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.
专利号:US-9447149-B2 优先权日:2012-03-06 标 题 :Methods and compositions for the rapid synthesis of radiometal-labeled probes 发明人:CHEN KAI; CONTI PETER STEPHEN 权利人:UNIV SOUTHERN CALIFORNIA 摘要:The present application is directed to rapid and efficient synthesis of radiometal-labeled probes, pharmaceutical compositions comprising radiometal-labeled probes, and methods of using the radiometal-labeled probes. Such radiometal-labeled probes can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT), and therapy studies.
专利号:US-2023278976-A1 优先权日:2021-07-05 标题:Synthesis Of Beta-Glycolipid Compounds 发明人:BOXLEY CHETT; STOLLEY RYAN; BRUGGEMAN ROBERT 权利人:GLYCOSURF INC 摘要:Methods of forming a glycolipid are disclosed. A method may include glycosylating a sugar with a beta-hydroxyester using BF3-L as a glycosylation promoter. L may include one or more of Diethylether, Tetrahydrofurn, Dimethyle Sulfide, or combinations thereof. The beta-hydroxyester may include a carbon length ranging from C2 to C24. The sugar may be a protected sugar that includes peracetylated-rhamnose, peracetylated-xylose, peracetylated-glucose, peracetylated-galactose or combinations thereof. The beta-hydroxyester and sugar may be combined in a reaction vessel to form a mixture. A solvent may be added to the mixture to substantially dissolve the mixture. The glycosylation promoter may be added to the solution such that the solution is maintained withing a desired temperature range.
专利号:US-11008358-B2 优先权日:2015-03-25 标题:Synthesis of desosamines 发明人:MYERS ANDREW G; ZHANG ZIYANG 权利人:HARVARD COLLEGE 摘要:The present invention provides desosamine and mycaminose analogs and nitro sugars and methods for their preparation. The invention also provides methods of cyclizing a compound of Formula (A′) with glyoxal to give a nitro sugar of Formula (B). Methods for the preparation of compound of Formula (D′) are provided comprising cyclization of a nitro alcohol to give a nitro sugar and reduction and alkylation of the nitro sugar to give a desosamine, mycaminose, or an analog thereof.
专利号:US-6444460-B1 优先权日:1998-08-19 标 题:Microbial production of actinol 发明人:SHIMIZU SAKAYU; WADA MASARU 权利人:ROCHE VITAMINS INC 摘要:A process for making (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone by contacting (6R)-2,2,6-trimethylcyclohexanedione with a microorganism which is selected from microorganisms of the genera Cellulomonas, Corynebacterium, Planococcus and Arthrobacter and which is capable of the selective asymmetric reduction of (6R)-2,2,6-trimethylcyclohexanedione to (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, and recovering the resulting (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone from the reaction mixture. The selective asymmetric reduction can be effected in the presence of a co-factor, such as, nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or said co-factor with glucose and glucose dehydrogenase (GDH), and/or in the presence of a surfactant. The product is useful for the synthesis of carotenoids, such as, zeaxanthin.
参考文献:10.1155/2011/824104 摘要:Cao H, He S, Wei R, Diong M, Lu L. Bacillus amyloliquefaciens G1: A Potential Antagonistic Bacterium against Eel‐Pathogenic Aeromonas hydrophila. Evidence-Based Complementary and Alternative Medicine. 2011 Jan;2011(1). doi: 10.1155/2011/824104.