CAS: 58546-34-2; (R)-6-Hydroxy-2-Methyl-5-Oxo-6-((2S,3S,8S,9R,10R,13R,14S,16R,17R)-2,3,16-Trihydroxy-4,4,9,13,14-Pentamethyl-11-Oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)Heptan-2-Yl Acetate

25-O-Acetyl-3-O-β-D-Glucopyranosyl-23,24-Dihydrocucurbitacin F置于盐酸体系中,化学反应 2.0H,反应生成 葫芦素 Iia
参考文献:Antidiabetic Properties Of Selected Mexican Copalchis Of The Rubiaceae Family
标题:Antidiabetic Properties Of Selected Mexican Copalchis Of The Rubiaceae Family
摘要:The Extracts Prepared From The Stem Barks Of Several Mexican Copalchis Species,Including Hintonia Latiflora,Exostema Caribaeum And A Commercial Mixture Of Hintonia Standleyana And E Caribaeum (Cm) Showed Significant Hypoglycemic And Antihyperglycemic Effects. The Extracts Were Tested In Three Different In Vivo Models Using Normal And Streptozotocin (Stz)-Induced Diabetic Rats. From The Active Extract Of H. Latiflora,25-O-Acetyl-3-O-Beta-D-Glucopyranosyl-23,24-Dihydrocucurbitacin F (1),An Analog Of 23,24-Dihydrocucurbitacin F,And Several Known Compounds (2 8) Were Isolated; Cucurbitacin I Was Also Isolated From H. Standleyana. Oral Administration Of H. Latiflora Extract [100 Mg/kg Of Body Weight (Bw)] And 5-O-Beta-D-Glucopyranosyl-7,3',4'-Trihydroxy-4-Phenylcoumarin (5) (30 Mg/kg Of Bw) To Stz-Induced Diabetic Rats,For A 30 Day Duration,Restored Blood Glucose Levels To Normal Values. The Groups Treated Either With The Active Principle 5,Or The Extract Of H. Latiflora,Showed Less Body Weight Loss Than Glibenclamide-Treated And Diabetic Control Groups (P < 0.05). It Was Also Demonstrated That The Extract Of H. Latiflora Regulated Hepatic Glycogen And Plasma Insulin Levels (P < 0.05). These Data Suggest That Its Antihyperglycemic Effect Is Due In Part To Stimulation Of Insulin Secretion And Regulation Of Hepatic Glycogen Metabolism. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Phytochem.2007.05.006