专利号:US-10975012-B2 优先权日:2017-09-28 标 题 :Synthesis of cyclic organic compounds 发明人:PADILLA-ACEVEDO ANGELA I 权利人:UNIVATION TECH LLC 摘要:A method comprising synthesizing a cyclic organic compound (3) via reaction of an substituted alkene (1) with an unsubstituted or substituted acrylic acid (2) in the presence of a sulfonic acid reagent to make the cyclic organic compound (3) R1(H)Câ•?C(H)R2 (1)
专利号:US-7772278-B2 优先权日:1999-03-01 标 题:Nitrosated and nitrosylated prostaglandins, compositions and methods of use 发明人:GARVEY DAVID S; GASTON RICKY D; LETTS L GORDON; DE TEJADA INIGO SAENZ; TAM SANG WILLIAM; WORCEL MANUEL 权利人:NITROMED INC 摘要:The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The invention also provides novel compositions comprising at least one prostaglandin and at least one S-nitrosothiol compound, and, optionally, at least one vasoactive agent. The prostaglandin is preferably a prostaglandin E 1 compound, more preferably alprostadil, and the S-nitrosothiol compound is preferably S-nitrosoglutathione. The invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing cerebrovascular disorders, cardiovascular disorders, benign prostatic hyperplasia (BPH), glaucoma, peptic ulcers or for inducing abortions.
专利号:WO-2019067276-A1 优先权日:2017-09-28 标题 :SYNTHESIS OF CYCLOPENTENONES USING SULFONIC ACID REAGENTS
专利号:US-2023023607-A1 优先权日:2020-02-06 标题 :Methods for practical synthesis of deuterated amino acids
专利号:EP-3687967-A1 优先权日:2017-09-28 标 题 :Synthesis of cyclopentenones with sulfonic acid reagents
专利号:BR-112020006177-A2 优先权日:2017-09-28 标题:synthesis of cyclopentenones with sulfonic acid reagents
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合成参考文献
摘要:Lam, K.; Leech, M. C.; Lennox, A. J. J., Science of Synthesis: Special Topics, (2021) 1, 474.