CAS: 56695-65-9; 7-(2-Hexyl-5-Hydroxycyclopentyl)Heptanoic Acid

该化合物是一个合成异丙二烯类象,主要作为血管病,具有生殖健康方面的应用,其特点是能够诱发子宫收缩,并经常研究其在妇科疗法中的潜在用途,包括劳动力诱导和某些生殖条件的管理;该化合物呈现出一种类似于自然产生的异丙二烯的结构,允许其与身体中特定受体相互作用,从而产生各种生理影响;由于它具有强大的生物活动和副作用的潜力,它通常以有控制的方式施用.其药理学特征包括对滑动肌肉的影响,特别是在子宫和血管中,使它成为临床和研究环境中感兴趣的一个对象.和许多丙二苯基类类似物一样,Rosaprostol的安全性和功效是其治疗应用中的重要考虑因素.

结构式图片

MSDS等安全信息

    上下游产品

    7-(2-hexyl-5-keto-cyclopentyl)-heptanoic acid

    合成工艺路线路线简述

      📜7-(2-Hexyl-5-Keto-Cyclopentyl)-Heptanoic Acid置于盐酸,Sodium Hydroxide,Sodium Borohydrid体系中,用 甲醇 作为反应溶剂,以88.5%的收率获得产物9-羟基-19,20-二去甲前列腺烷酸
      参考文献:Process For Preparing 7-(2-Hexyl-5-Hydroxy-Cyclopentyl)-Heptanoic Acid
      标题:Process For Preparing 7-(2-Hexyl-5-Hydroxy-Cyclopentyl)-Heptanoic Acid
      摘要:描述了制备7-(2-己基-5-羟基环戊基)-庚酸的多步过程.还描述了新型中间体.

      海关参考信息

      专利信息


      专利号:US-10975012-B2
      优先权日:2017-09-28
      标 题 :Synthesis of cyclic organic compounds
      发明人:PADILLA-ACEVEDO ANGELA I
      权利人:UNIVATION TECH LLC
      摘要:A method comprising synthesizing a cyclic organic compound (3) via reaction of an substituted alkene (1) with an unsubstituted or substituted acrylic acid (2) in the presence of a sulfonic acid reagent to make the cyclic organic compound (3) R1(H)Câ•?C(H)R2 (1)

      专利号:US-7772278-B2
      优先权日:1999-03-01
      标 题:Nitrosated and nitrosylated prostaglandins, compositions and methods of use
      发明人:GARVEY DAVID S; GASTON RICKY D; LETTS L GORDON; DE TEJADA INIGO SAENZ; TAM SANG WILLIAM; WORCEL MANUEL
      权利人:NITROMED INC
      摘要:The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The invention also provides novel compositions comprising at least one prostaglandin and at least one S-nitrosothiol compound, and, optionally, at least one vasoactive agent. The prostaglandin is preferably a prostaglandin E 1 compound, more preferably alprostadil, and the S-nitrosothiol compound is preferably S-nitrosoglutathione. The invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing cerebrovascular disorders, cardiovascular disorders, benign prostatic hyperplasia (BPH), glaucoma, peptic ulcers or for inducing abortions.

      专利号:WO-2019067276-A1
      优先权日:2017-09-28
      标题 :SYNTHESIS OF CYCLOPENTENONES USING SULFONIC ACID REAGENTS

      专利号:US-2023023607-A1
      优先权日:2020-02-06
      标题 :Methods for practical synthesis of deuterated amino acids

      专利号:EP-3687967-A1
      优先权日:2017-09-28
      标 题 :Synthesis of cyclopentenones with sulfonic acid reagents

      专利号:BR-112020006177-A2
      优先权日:2017-09-28
      标题:synthesis of cyclopentenones with sulfonic acid reagents

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Łukasik B, Perlikowska W, Żurawiński R, Mikołajczyk M. Synthesis of Enantiomerically Pure Stereomers of Rosaprostol. J Org Chem. 2015 Oct 2;80(19):9798-802. doi: 10.1021/acs.joc.5b01749. eCollection 2016.
      4: Tincani GP, Maniscalco G, Gunelli M, Ciarrocchi V. [Treatment of duodenal ulcer with rosaprostol in patients resistant to treatment with anti-H2]. Minerva Med. 1987 Jun 30;78(12):847-53. Italian. Italian. Italian. doi: 10.1111/j.1471-4159.2009.06067.x. Epub 2009 Mar 26. Review. doi: 10.1016/j.neulet.2008.05.039. Epub 2008 May 16.

      合成参考文献


      摘要:Lam, K.; Leech, M. C.; Lennox, A. J. J., Science of Synthesis: Special Topics, (2021) 1, 474.
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