CAS: 503610-43-3; N-(4-(4-Fluorophenyl)-5-((E)-2-((2S,4R)-4-Hydroxy-6-Oxotetrahydro-2H-Pyran-2-yl)Vinyl)-6-Isopropylpyrimidin-2-yl)-N-Methylmethanesulfonamide

上下游产品

CAS号287714-41-4 罗伐他汀 | CAS号851440-19-2 2-((4R,6S)-6-((... | CAS号355805-96-8 Rosuvastatin me... | CAS号355806-00-7 瑞舒伐他汀叔丁酯 | CAS号1353637-13-4 E-(6-{2-[2-(N-m... | CAS号851440-18-1 (6-{(E)-2-[4-(4... | CAS号124655-09-0 (4R-Cis)-6-羟甲基-... | CAS号147118-36-3 4-(4-氟苯基)-6-异丙基...

罗伐他汀 以 甲苯 作为反应溶剂,化学反应 22.0H,反应生成 瑞舒伐他汀内酯
参考文献: Process For The Preparation Of Statins In The Presence Of Base[fr] Procédé De Préparation De Statines En Présence D'Une Base
标题: Process For The Preparation Of Statins In The Presence Of Base[fr] Procédé De Préparation De Statines En Présence D'Une Base
摘要:本发明涉及一种通过在碱性金属烷氧基存在下,通过醛和磺酮衍生物之间的julia-Kocienski反应制备他汀的方法.所得的衍生物适用于他汀类化合物的构建模块,如西立伐他汀,氟伐他汀,匹伐他汀和罗伐他汀.

专利信息

专利号:US-8471045-B2
优先权日:2007-04-03
标题 :Synthesis of statins
发明人：CASAR ZDENKO; MESAR TOMAZ; KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ
权利人:CASAR ZDENKO; MESAR TOMAZ; KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ; LEK PHARMACEUTICALS
摘要:The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.

专利号:US-9067895-B2
优先权日:2009-12-16
标题 :Processes for the preparation of key intermediate for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof
发明人：ANDRENSEK SAMO; ANZEL JOLANDA; HOCEVAR MARJETA; CASAR ZDENKO
权利人:ANDRENSEK SAMO; ANZEL JOLANDA; HOCEVAR MARJETA; CASAR ZDENKO; LEK PHARMACEUTICALS
摘要:The present invention relates in general to the field of organic chemistry and in particular to a process for the preparation of 5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonylamino)pyrimidine (RSVL) as well as a process for preparing crystalline 5-((E)-2-((2S,4R)-4-(tert-butyldimethylsilyloxy)-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethanesulfonylamino)pyrimidine (RSVLTBS) useful as key intermediates for the preparation of rosuvastatin or pharmaceutically acceptable salts thereof.

专利号:WO-2011073232-A1
优先权日:2009-12-16
标 题 :Process for the preparation of key intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof

专利号:EP-2602249-B1
优先权日:2011-12-06
标题:Synthesis of rosuvastatin by means of co-crystals

专利号:US-2012022091-A1
优先权日:2009-02-02
标题:Key intermediates for the synthesis of rosuvastatin or pharmaceutically acceptable salts thereof

专利号:US-2011178295-A1
优先权日:2007-04-03
标 题:Synthesis of statins