专利号:US-2013296346-A1 优先权日:2010-11-23 标题 :Diphenyl-amine derivatives: uses, process of synthesis and pharmaceutical compositions 发明人:RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO 权利人:RODES SOLANES ROSA; GARCIA DOMINGUEZ NEFTALI; LOPEZ ORTEGA BEATRIZ; ALVAREZ DE MON SOTO MELCHOR; DE LA HERA MARTINEZ ANTONIO; MUNOZ MUNOZ ANA; LEDO GOMEZ FRANCISCO; FAES FARMA SA 摘要:The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, a method of synthesis of said compounds, pharmaceutical compositions comprising them and their use as a medicament for treating inflammatory diseases.
专利号:US-6723852-B2 优先权日:2000-04-14 标题:Method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzomidazol 发明人:BERENGUER MAIMO RAMON; COPPI LAURA 权利人:ESTEVE QUIMICA SA 摘要:The method for obtaining derivatives of [[(pyridil substituted)methyl]thio]benzomidazol (I), where each of R1, R3 and R4, independently of each other, is hydrogen, an alkyl, alkoxy or fluorinated alkoxy of 1 to 6 carbon atoms, and R2 is nitro, halogen, alkoxy or halogenated alkoxy of 1 to 6 carbon atoms, or a group -OR-(CH2)n-OR8, where n is an integer between 1 and 6 and R8 represents hydrogen or an alkyl group with 1 to 6 carbon atoms, which involves (a) reacting an N-oxide of a methylpyridine with an anhydride of activated carboxylic acid or of sulfonic acid, and (b) reacting the intermediate formed in stage (a) with a corresponding mercaptobenzomidazol. The compounds (I) are useful in the synthesis of derivatives of [[(pyridil substituted)methyl]sulfinyl]benzomidazol, such as omeprazol, lansoprazol, rabeprazol or pantoprazol.
专利号:US-6482949-B1 优先权日:1999-05-28 标题 :Colormetric sensor compositions and methods 发明人:SESSLER JONATHAN; ANDRIOLETTI BRUNO; TRY ANDREW CARL; BLACK CHRISTOPHER 摘要:The present invention provides novel compounds exemplified by pyrrolic nitrogens used as anion and neutral species recognition elements with an aromatic core as a signal group. Described are methods for the synthesis of various pyrrole aryl compounds as well as various applications for these compounds. Methods of use include the binding and detection of specific analytes in a mixture and, in some examples, the separation of the analyte from the mixture. Additional methods of use include the transport of therapeutic agents and the sensing of components, degradants, and impurities in foodstuffs.
专利号:EP-1173405-A4 优先权日:2000-01-27 标题 :SYNTHESIS OF THE N4, N4'-DIPEHNYL-N4, N4'-DI-M-TOLYL-BIPHENYL-4,4'-DIAMINE STARTING FROM AN UNSYMMETRICAL AMINE
专利号:US-6407289-B1 优先权日:2000-01-27 标 题:Synthesis of N4, N4-diphenyl-N4,N4-di-m-tolyl-biphenyl-4,4'-diamine from an unsymmetrical amine 发明人:RUSSO-RODRIGUEZ SANDRA; SULLIVAN JEFFREY M 权利人:BOULDER SCIENT CO 摘要:Novel (4-halophenyl) biphenyl tolyl amines are described.
专利号:JP-2014503623-A 优先权日:2010-12-03 标 题:A method for the synthesis of precursor complexes of titanium dioxide sensitizing dyes based on ruthenium polypyridine complexes.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 168. 摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 1, 475. 摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 386. 摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 384.