CAS: 478336-92-4; Methyl 2-(3-(4-Hydroxyphenyl)-4,5-Dihydroisoxazol-5-yl)Acetate

该化合物是一种化学化合物,其特征是异氧代诺琴环结构,有助于其独特的反应和生物特性,该化合物具有甲基酯功能组,提高了其溶性,增加了其生物利用率和潜在利用率;4-羟基苯组的存在表明,该化合物可能表现出苯酚特性,可能影响其抗氧化活动和与生物系统的互动;二氢化合物的配置表明,该化合物具有饱和部分,与完全不饱和的模拟相比,可能会影响其稳定性和再活动性;

结构式图片

上下游产品

CAS号1056465-52-1 1-(4-hydroxyphe... | CAS号109272-34-6 1-(4-hydroxyphe... | CAS号123-08-0 4-羟基苯甲醛; 对羟基苯甲醛 | CAS号699-06-9 4-羟基苯甲醛肟

合成工艺路线路线简述

    N-[1-[4-[tert-Butyl(Diphenyl)Silyl]Oxyphenyl]But-3-Enylidene]Hydroxylamine置于palladium Dichloride Potassium Fluoride,18-冠醚-6,Copper Dichloride体系中,用 二氯甲烷,水 作为反应溶剂,化学反应生成 4,5-二氢-3-(4-羟基苯基)-5-异恶唑乙酸甲酯
    参考文献:δ 2从β-Isoxazolines,γ不饱和肟
    标题:δ 2从β-Isoxazolines,γ不饱和肟
    摘要:3,5-二取代的δ 2-Isoxazolines可使用β,γ不饱和肟的钯介导nucleometalation /甲氧基羰基来制备.这种通往这类化合物的新颖途径可耐受起始材料中的多种官能团,并提供了快速途径来制备高度官能化的异恶唑啉.
    DOI:10.1002/jhet.5570430303

    海关参考信息

    专利信息


    专利号:US-2013172553-A1
    优先权日:2009-11-25
    标题 :Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof
    发明人:SIELECKI-DZURDZ THAIS; PRUITT JAMES
    权利人:SIELECKI-DZURDZ THAIS; PRUITT JAMES; CPSI STOCKHOLDER TRUST
    摘要:Processes for the chiral syntheses of isoxazolines and intermediates are described. Compounds prepared thereby, and methods of using the compounds are also described.

    专利号:CA-2418458-A1
    优先权日:2003-02-06
    标题:Total synthesis of 14 beta-fluorosteroids via the transannular diels-alder reaction

    专利号:WO-2011066482-A2
    优先权日:2009-11-25
    标题 :Chiral synthesis of isoxazolines, isoxazoline compounds, and uses thereof

    专利号:US-2024118579-A1
    优先权日:2022-09-09
    标 题 :Optometaphoresis: programmable metaphotonics by particle migration and light-bending in nanoparticle colloids controlled by near-field micro-structured current-voltage-energized phased-array antenna-electrodes inducing dielectrophoresis
    发明人:DIDOMENICO LEO D
    权利人:DIDOMENICO LEO D
    摘要:Optometaphoresis is a new form of software programmable optics wherein light is controlled by the migration of a large number of particles in a colloid due to radio frequency signals injected into the colloid by a near-field micro-structured current-voltage-energized phased-array antenna-electrode that impress dielectrophoretic forces and torques on nanoparticles in the colloid. This creates a fluidic metamaterial that affects the propagation of light (ultraviolet, visible light, infrared, THz waves, millimeter waves, etc.) passing through the colloid. The migration modalities of the particles include translation, orientation, and deformation of particles in a colloid. Optometaphoresis synthesis the central quantity to all optics: Refractive Index. Light may be refracted, reflected, diffracted, guided, and even polarized within the optometaphoresis system by bending light.
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    主要参考文献


    1: Wang X, Ma S, Wu H, Shen X, Xu S, Guo X, Bolick ML, Wu S, Wang F. Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition. Exp Mol Med. 2018 Feb 16;50(2):e445. doi: 10.1038/emm.2017.271. doi: 10.1186/s12866-018-1156-1.
    3: Kim B, Kusibati R, Heisler-Taylor T, Mantopoulos D, Ding J, Abdel-Rahman MH, Satoskar AR, Godbout JP, Bhattacharya SK, Cebulla CM. MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment. Sci Rep. 2017 Oct 30;7(1):14336. doi: 10.1038/s41598-017-14298-9.
    4: Abdul-Aziz AM, Shafat MS, Mehta TK, Di Palma F, Lawes MJ, Rushworth SA, Bowles KM. MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia. Cancer Res. 2017 Jan 15;77(2):303-311. doi: 10.1158/0008-5472.CAN-16-1095. Epub 2016 Nov 21. doi: 10.1155/2016/2174682. Epub 2016 May 23.

    合成参考文献


    参考文献:10.1111/j.1365-2567.2008.02825.x
    摘要:West PW, Parker LC, Ward JR, Sabroe I. Differential and cell‐type specific regulation of responses to Toll‐like receptor agonists by ISO‐1. Immunology. 2008 Aug 06;125(1):101–10. doi: 10.1111/j.1365-2567.2008.02825.x.
    参考文献:10.1186/s12865-019-0306-z
    摘要:Hao J, Lv T, Xu L, Ran M, Wu K. Macrophage migration inhibitory factor is involved in antineutrophil cytoplasmic antibody-mediated activation of C5a-primed neutrophils. BMC Immunology. 2019 Jun 27;20(1):22. doi: 10.1186/s12865-019-0306-z.
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