CAS: 37739-05-2; Ccpa

相似化合物

146-77-0 4338-48-1 34408-14-5

上下游产品

CAS号3056-18-6 9-[2,3,5-三-O-乙酰... | CAS号1003-03-8 环戊胺 | CAS号6979-94-8 2',3',5'-三乙酰鸟苷 | CAS号41552-82-3 N6-环戊基腺苷酸

📜2',3',5'-三乙酰鸟苷置于ammonium Hydroxide,三甲基氯硅烷,亚硝酸特丁酯,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应 4.0H,反应生成2-氯-N6-环戊基腺苷
参考文献:2-卤代-O6-(苯并三唑-1-基)-功能化嘌呤核苷的合成和应用
标题:2-卤代-O6-(苯并三唑-1-基)-功能化嘌呤核苷的合成和应用
摘要:2-卤代-O6-(苯并三唑-1-基)-取代的嘌呤核苷的有效合成是通过(苯并三唑-1-基氧基)三(二甲氨基)鏻六氟磷酸(Bop)介导的偶联和随后通过重氮化的卤化完成的各种受保护鸟苷的 2-氨基,直接来自鸟苷本身.这些产品适合在 2 位和 6 位进行取代和偶联反应,因此可以有效地获得高度官能化的嘌呤核苷.
Doi:10.1002/ejoc.201001395

专利信息

专利号:US-12018313-B2
优先权日:2016-12-28
标题:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles
发明人：EMBREE MALLORY
权利人:NATIVE MICROBIALS INC
摘要:Methods, apparatuses, and systems for microorganism strain analysis of complex heterogeneous communities with tracer analytics, determination of functional relationships and interactions thereof, and synthesis of microbial ensembles, including dosed microbial ensembles and inoculative microbial ensembles, are disclosed.

专利号:WO-9614060-A1
优先权日:1994-11-04
标题 :Use of receptor agonists to stimulate superoxide dismutase activity
发明人：MARKLUND STEFAN L; STRAALIN PONTUS
权利人:MARKLUND STEFAN L; STRAALIN PONTUS
摘要:The present invention relates to the use of a substance for the manufacture of a composition for stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells. In particular, the invention relates to the use of a substance for the manufacture of a composition for prophylaxis or treatment of a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical. Further, the invention relates to a method for determining the effect of a substance with respect to stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells and to substances which have been selected by said method. Within the scope of the invention is a method of preventing, diminishing, controlling or inhibiting a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical in a patient who has been established to have a high risk of developing a such disease or disorder, or who has developed a such disease or disorder, the method comprising administering an effective amount of a substance which is capable of stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells.

专利号:US-9018371-B2
优先权日:2007-03-07
标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient
发明人：JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH
权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO
摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.

专利号:US-2024368164-A1
优先权日:2021-04-28
标 题 :Purine nucleosides, their intermediates, and methods of preparation thereof
发明人：RAVI RAMA SURESH; JACOBSON KENNETH A; POE RUSSELL BIRCH
权利人:ASTROCYLE PHARMACEUTICALS INC; US HEALTH
摘要:The present invention provides purine nucleoside analog compounds and methods of use thereof for treatment of certain injuries, disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries. The present invention further provides methods of synthesizing such compounds, and intermediates useful in the synthesis of such compounds.

专利号:WO-2024168196-A1
优先权日:2023-02-08
标 题:Systems and methods for enzymatic synthesis of polynucleotides containing non-standard nucleotide basepairs
发明人：MARCHAND JORGE; KAWABE HINAKO
权利人:UNIV WASHINGTON
摘要:Systems and methods for generating defined base pairs in a sequence-defined library format that include at least one non-standard nucleotide in a base pair. Non-standard base pairs can be created using a nucleic acid polymerase ( e.g. , DNA polymerase, RNA polymerase, terminal deoxynucleotide polymerase) for blunt-end tailing addition of the non-standard base, which then can be ligated to another nucleotide end. The nucleotide sequences containing non-standard base pairs can be used to generate libraries for basecalling models of the non-standard base with next-generation sequencing (NGS) platforms and sequencing non-standard nucleotide sequences, including xenonucleotide (XNAs).

专利号:US-6645513-B2
优先权日:1998-10-26
标题 :Treatment of skin with adenosine or adenosine analog
发明人：DOBSON JR JAMES G; ETHIER MICHAEL F
权利人:UNIV MASSACHUSETTS
摘要:Methods for enhancing the condition of non-diseased skin by application of compositions containing adenosine or an adenosine analog are disclosed. Also disclosed are methods for increasing DNA synthesis or protein synthesis in dermal cells, and methods for increasing dermal cell size, by application of compositions containing adenosine.