CAS: 364-74-9; 2,5-Difluoronitrobenzene

上下游产品

CAS号540-36-3 1,4-二氟苯 | CAS号97-00-7 1-氯-2,4-二硝基苯 | CAS号367-30-6 2,5-二氟苯胺 | CAS号394-33-2 4-氟-2-硝基苯酚 | CAS号367-30-6 2,5-二氟苯胺 | CAS号107751-26-8 2,2',5,5'-tetra... | CAS号142596-59-6 1-叔丁氧基-4-氟-2-硝基苯 | CAS号146366-00-9 N-ISOPROPYL-4-F... | CAS号143925-43-3 N-(2,5-difluoro... | CAS号147124-38-7 Methyl (4-fluor... | CAS号142744-16-9 N-[2-[[5-[(dime... | CAS号398-90-3 2,5-二氟乙酰苯胺 | CAS号719-70-0 1-(4-氟-2-硝基苯基)哌啶

1,4-二氟苯置于nitronium Tetrafluoborate体系中,用 环丁砜 用作溶剂,化学反应生成2,5-二氟硝基苯
参考文献:芳烃替代品.Vii.1Friedel-Crafts 型芳烃硝化2
标题:芳烃替代品.Vii.1Friedel-Crafts 型芳烃硝化2
摘要:在均相四亚甲基砜溶液中研究了芳烃与硝基卤化物,四氧化二氮,五氧化二氮和稳定的硝鎓盐的 Friedel-Crafts 型硝化.发现了一种由硝酸hf和bf2制备四氟硼酸硝鎓的简单新方法.氟硼酸盐硝化制备硝基硝基脲的范围扩大到各种取代芳烃.
Doi:10.1021/ja01483A016

专利信息

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-6514981-B1
优先权日:1998-04-02
标题:Methods of modulating tyrosine protein kinase function with indolinone compounds
发明人：TANG PENG CHO; SUN LI
权利人:SUGEN INC
摘要:The invention relates to certain indolinone compounds, their method of synthesis, and a combinatorial library consisting of the indolinone compounds. The invention also relates to methods of modulating the function of protein tyrosine kinases using indolinone compounds and methods of treating diseases by modulating the function of protein tyrosine kinases and related signal transduction pathways.

专利号:CN-108997177-A
优先权日:2018-09-04
标题 :A kind of microwave-promoted method for the synthesis of N-benzenesulfonylnitroaniline compounds

专利号:US-2011046395-A1
优先权日:2008-01-25
标 题 :Process for the manufacture of a 6-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene derivative
发明人：RALL WERNER; PFRENGLE WALDEMAR; SCHNAUBELT JUERGEN
权利人:BOEHRINGER INGELHEIM INT
摘要:The present invention relates to a process for the manufacture of the compound 4-[(Z)-[[4-[(dimethylamino)methyl]phenyl]amino](6-fluoro-1,2-dihydro-2-oxo-3H-in-dol-3-ylidene)methyl]-benzenepropanoic acid and to a new intermediate for the synthesis.

专利号:CN-101811973-A
优先权日:2010-04-23
标 题 :A method for the synthesis of halogenated arylamines by highly selective liquid-phase hydrogenation under solvent-free conditions

专利号:US-6096763-A
优先权日:1995-02-23
标题 :α1a adrenergic receptor antagonists
发明人：HOFFMAN JACOB M; CHANG RAYMOND S L
权利人:MERCK & CO INC
摘要:This invention relates to novel compounds, their synthesis and use as selective α 1a adrenergic receptor antagonists. One application of the compounds is in the treatment of benign prostatic hyperplasia. The compounds are selective in their ability to relax smooth muscle tissue enriched in the α 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.