CAS: 35989-16-3; 2-(Methylamino)Pentanedioic Acid

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1155-62-0 121343-82-6 2419-94-5

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CAS号19525-56-5 3-(2-oxo-3-phen... | CAS号1155-62-0 N-苄氧羰基-L-谷氨酸 | CAS号328-50-7 α-酮戊二酸 | CAS号74-89-5 氨基甲烷 | CAS号151-50-8 氰化钾

📜N-Benzyloxycarbonyl-N-Methyl-Dl-Glutamic Acid置于palladium On Activated Charcoal 氢气体系中,用 乙醇 作为反应溶剂,以63%的收率获得产物n-甲基-Dl-谷氨酸
参考文献:Synthesis And Structural Characterization Of N-Methyl-Dl-Glutamic Acid
标题:Synthesis And Structural Characterization Of N-Methyl-Dl-Glutamic Acid
摘要:通过单晶x射线衍射技术,定义了混合的n-甲基谷氨酸的固态构象.正交晶体属于空间群pbca,A为15.219(2) å,B为10.583(1) å,C为9.595(1) å,Z为8.该结构被精细地修正到最终的r值为0.049,共测量了1285个数据.在晶体中,分子采用带电离子形式,氨基氮原子发生了质子化.α-羧基未质子化,而d-羧基保留了质子.红外光谱表明,氨基酸处于带电离子形式.晶体中的分子通过羧酸质子和n原子上的两个质子之间的分子间氢键连接成三维网络.
DOI:10.1071/ch99182

专利信息

专利号:US-10427126-B2
优先权日:2015-10-28
标题 :System and method for longitudinal analysis of peptide synthesis
发明人：Bannen Ryan; Barilovits Sarah; PATEL JIGAR; SULLIVAN ERIC; TAN JOHN
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present invention provides a system and method for assessing a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a binder sequence. The population of peptide features is synthesized over a plurality of synthesis periods and includes a plurality of control peptide features synthesized to have an amino acid sequence including the binder sequence. The control peptide features include a first feature synthesized beginning with a first one of the synthesis periods, and a second feature synthesized beginning after the first one of the synthesis periods such that synthesis of the second control peptide feature is delayed by at least one synthesis period. The method further includes detecting a signal output characteristic of an interaction of the receptor with the control peptide features, the signal output indicative of the fidelity of synthesis of the population of peptide features.

专利号:US-9346892-B2
优先权日:2011-03-18
标题 :Methods for synthesis of an oligopeptide microarray
发明人：ALBERT TOM; RICHMOND TODD; RODESCH MATTHEW; STENGELE KLAUS-PETER; BUEHLER JOCHEN; OTT MARKUS
权利人:ALBERT TOM; RICHMOND TODD; RODESCH MATTHEW; STENGELE KLAUS-PETER; BUEHLER JOCHEN; OTT MARKUS; ROCHE NIMBLE GEN INC
摘要:An oligopeptide microarray and methods for the synthesis thereof are presented. Further presented is a microarray on a solid support comprising at least about 10,000 oligopeptide features per cm 2 and preferably at least about 50,000 oligopeptide features per cm 2 .

专利号:US-2005004225-A1
优先权日:2003-04-16
标题:Oxidoreductase inhibitors and methods of screening and using thereof
发明人：BALENDIRAN GANESARATNAM K
摘要:The present invention relates to 1) the design and synthesis of analogs to glutathione conjugates which bind to or interact with aldose reductase (AR) through unique conformations that are distinctly different from the substrates and inhibitors of AR which are members of sugar metabolism; 2) the screening of the analogs to identify those that interact with or inhibit or enhance the activity of AR; and 3) the use of AR ligands, AR inhibitors (AR antagonsits) or AR enhancer (AR agonists) in the detection of AR activity, the modulation of AR activity, and the treatment of conditions in a subject in need of modulating AR activity. Such conditions include but not limited to cardiovascular disease, diabetes, artheriosclerosis, cancer, neoplasm, obesity, cataract, retinopathy, keratopathy, nephropathy, neurosis, thrombosis, faulty union of corneal injury and neuropathy. Examples of the treatment include the use of fibrates as AR inhibitors to treat these conditions.

专利号:US-2024400861-A1
优先权日:2021-10-01
标题 :Triazole- And/Or Triazolium-Based Polymers And Copolymers As Additives For Chemical Mechanical Planarization Slurries
发明人：LARBIG GREGOR; KIRSCH PEER; HENGST MATTHIAS; SHI XIAOBO; STENDER MATTHIAS
权利人:VERSUM MAT US LLC
摘要:Synthesis of triazole- and/or triazolium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising triazole- and/or triazolium-based polymers; and water. The use of the synthesized triazole- and/or triazolium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

专利号:US-8658572-B2
优先权日:2011-03-18
标题 :Whole proteome tiling microarrays
发明人：ALBERT TOM; RICHMOND TODD; RODESCH MATTHEW; STENGELE KLAUS-PETER; BUEHLER JOCHEN
权利人:ALBERT TOM; RICHMOND TODD; RODESCH MATTHEW; STENGELE KLAUS-PETER; BUEHLER JOCHEN; ROCHE NIMBLEGEN INC
摘要:The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm 2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm 2 . In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.

专利号:US-10641778-B2
优先权日:2015-08-25
标 题 :System and method for analysis of peptide synthesis fidelity
发明人：Bannen Ryan; Barilovits Sarah; PATEL JIGAR; SULLIVAN ERIC; TAN JOHN
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present invention provides a system and method for assessing the fidelity of a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a plurality of binder sequences. A first amino acid is at a defined position within a first one of the binder sequences, and the population of peptide features includes a first control peptide feature synthesized to have an amino acid sequence including the first one of the binder sequences. The system and method further includes detecting a signal output characteristic of an interaction of the receptor with the first control peptide feature. The signal output is indicative of the fidelity of incorporation of the first amino acid into the first control peptide at the defined position within the first one of the binder sequences.