CAS: 3304-70-9; Dimethyl 4,5-Imidazoledicarboxylate

该化合物是有机合成的多用途中间体,特别因其在制造以imidazole为基础的化合物方面的作用而得到重视.其二甲基酯功能提高了有机溶剂的溶性,有利于进一步的衍生.该化合物的硬性imidazole核心有助于其协调化学的稳定性和效用,使其适合催化剂系统中的离子和设计.其结构特征还有利于药物和农用化学研究的应用,因为那里经常使用imidazole衍生物.该产品高纯度和定义明确的再活性特征确保合成工作流程的一贯性.建议在惰性条件下进行适当的处理和储存以保持其完整性.

结构式图片

相似化合物

570-22-9 321970-25-6 85110-06-1

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号67-56-1 甲醇 | CAS号570-22-9 咪唑-4,5-二羧酸 | CAS号59157-08-3 5,10-dioxo-5H,1... | CAS号33457-48-6 4,5-双(羟甲基)咪唑 | CAS号17998-43-5 4,7-二氯-1H-咪唑并[4... | CAS号28683-00-3 4H-Imidazo[4,5-... | CAS号82032-43-7 5-(羟甲基)-1H-咪唑-4-羧酸甲酯 | CAS号83-39-6 咪唑-4,5-二甲酰胺 | CAS号705280-65-5 2-溴-1H-咪唑-4,5-二羧酸二甲酯 | CAS号59157-07-2 4,5-di(N-phenyl... | CAS号13189-13-4 1H-Imidazole-5-... | CAS号321970-25-6 1-苄基-1H-咪唑-4,5-... | CAS号19485-38-2 1-甲基-1H-咪唑-4,5-二羧酸

合成工艺路线路线简述

    甲醇,咪唑-4,5-二羧酸置于硫酸体系中,化学反应 24.0H,以78%的收率获得1H-咪唑-4,5-二甲酸二甲酯
    参考文献:A New Generation Of Aprotic Yet Brønsted Acidic Imidazolium Salts: Low Toxicity,High Recyclability And Greatly Improved Activity
    标题:A New Generation Of Aprotic Yet Brønsted Acidic Imidazolium Salts: Low Toxicity,High Recyclability And Greatly Improved Activity
    摘要:已开发出低抗菌毒性且非质子性,但在质子性添加剂存在下能作为布伦斯特酸催化剂的催化剂.这些催化剂可循环使用,活性显著提高(即使用量可减少10至50倍),并且适用范围比前一代更广.
    Doi:10.1039/c3Gc40975A

    海关参考信息

    专利信息


    专利号:US-6258323-B1
    优先权日:1998-11-16
    标题:Apparatus and method used in multiple, simultaneous synthesis of general compounds
    发明人:HORMANN ROBERT EUGENE; GILBERT DARYL EUGENE; SIOMA EDWARD MICHAEL
    权利人:ROHM & HAAS
    摘要:The apparatus and method of the present invention provides for conducting simultaneous multiple synthesis of general compounds, which often takes place under varied uneven conditions requiring heating, cooling, agitation, reagent/solvent additions to the reactor contents at each reaction vessel location, supply and maintenance of inert atmosphere and means to facilitate the reflux of the reactor contents. Thus, it becomes necessary to monitor and control the reaction conditions during the simultaneous multiple synthesis of general compounds. The apparatus allows the user to connect various independently controlling and conveying means to each reaction vessel through multiple ports provided on a stopper mounted on each reaction vessel. The apparatus of the present invention permits user to readily access the reaction vessels without interrupting the reactions occurring in the adjacent reaction vessels. The unique geometry and shape of the stopper allows positioning of multiple ports, while still providing the stopper with a compact size. As a result, a large array of reaction vessels can be accommodated in the device of the present invention without significantly increasing the overall size of the apparatus. Some of the general compounds that can be readily synthesized by the apparatus and the method of the present invention include inorganic compounds as well as organic compounds, such as oligomers, polymers, agricultural chemicals, drugs, peptides and oligonucleotides.

    专利号:US-2002077491-A1
    优先权日:2000-09-05
    标 题 :Methods for forming combinatorial libraries combining amide bond formation with epoxide opening
    发明人:SHIPPS GERALD W; ROSNER KRISTIN E; MAKARA GERGELY M; WINTNER EDWARD A; NASH HUW M; FELSCH JASON S; PAL KOLLOL; LENZ GEORGE R
    摘要:The invention relates to methods for forming combinatorial libraries. The invention provides methods suitable for the rapid and convenient synthesis of very large combinatorial libraries of small organic molecules. In particular, the invention provides a method for forming combinatorial libraries combining amide bond formation with epoxide opening.

    专利号:US-2905692-A
    优先权日:1958-02-28
    标 题:Synthesis of imidazoles
    发明人:PALEVEDA WILLIAM J; SCHOENEWALDT ERWIN F
    权利人:MERCK & CO INC
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    合成参考文献


    参考文献:10.1134/s1070428023130183
    摘要:Sofia Z, Nathalie K. A Simple, Efficient Synthesis and Molecular Docking of Imidazole Derivatives as a Promising Anticancer Active Drugs. Russ J Org Chem. 2023 Dec;59(S1):S164–71. doi: 10.1134/s1070428023130183.
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