CAS: 220405-40-3; 2,2-Difluoro-1,3-Dimethylimidazolidine

上下游产品

2-chloro-1,3-dimethylimidazolinium chloride 2,2-dichloro-1,3-dimethylimidazolidine difluorodiphenylsilane N-B°C-3,4-didehydro-(S)-proline methyl ester (S)-1-tert-butyl 2-methyl 2,3-dihydro-1H-pyrrole-1,2-dicarboxylate 1-tert-butyl 2-methyl (2S,4S)-4-fluoropyrrolidine-1,2-dicarboxylate

2,2-Dichloro-1,3-Dimethylimidazolidine置于potassium Fluoride体系中,用 乙腈 用作溶剂,化学反应生成2,2-二氟-1,3-二甲基咪唑烷
参考文献:[de] Verfahren Zur Herstellung Von Guanidinium-Salzen Method For Producing Guanidinium Salts[fr] Procede De Production De Sels De Guanidinium
标题:[de] Verfahren Zur Herstellung Von Guanidinium-Salzen Method For Producing Guanidinium Salts[fr] Procede De Production De Sels De Guanidinium
摘要:This Invention Relates To A Two-Step Process For The Production Of Guanidinium Salts Of Formula (1),Wherein The Substituents R Have The Meaning As Defined In Claim 1 And A-Is A Sulfonate,Alkyl Or Aryl Sulfate,Hydrogen Sulfate,Imide,Methanide,Carboxylate,Phosphate,Phosphinate,Phosphonate,Borate,Thiocyanate,Perchlorate,Fluorosilicate,Or Nitrate,As Well As Intermediates From This Process.

专利信息

专利号:US-8324417-B2
优先权日:2009-08-19
标题:Process for the preparation of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid and alkyl esters and acid salts thereof
发明人：HART BARRY; DENER JEFF; GREEN MICHAEL; STANDEN MICHAEL; KOCIAN OLDRICH
权利人:HART BARRY; DENER JEFF; GREEN MICHAEL; STANDEN MICHAEL; KOCIAN OLDRICH; VIROBAY INC
摘要:The present invention relates to a process for the preparation of alkyl esters of (S)-2-amino-5-cyclopropyl-4,4-difluoropentanoic acid, which are intermediates useful in the synthesis of (S)—N-(1-cyanocyclopropyl)-5-cyclopropyl-4,4-difluoro-2-((S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethylamino)pentanamide and related compounds, which are compounds that are cysteine protease inhibitors.

专利号:WO-2024064745-A1
优先权日:2022-09-21
标 题:Synthesis of reldesemtiv
发明人：PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE
权利人:CYTOKINETICS INC
摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.

专利号:US-9181203-B2
优先权日:2010-11-12
标题:Substituted pyrazino[2,3-d]isooxazoles as intermediates for the synthesis of substituted pyrazinecarbonitriles and substituted pyrazinecarboxamides
发明人：NAKAMURA KOUKI; MURAKAMI TAKESHI; NAITOU HIROYUKI; HANAKI NAOYUKI; WATANABE KATSUYUKI
权利人:FUJIFILM CORP; TOYAMA CHEMICAL CO LTD
摘要:The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): n nwherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(â•?O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.

专利号:US-2018016227-A1
优先权日:2015-02-03
标题:Process for the synthesis of difluoromethyl ether-based compounds
发明人：SLASSI ABDELMALIK; DOVE PETER
权利人:TRILLIUM THERAPEUTICS INC
摘要:The present application relates to a novel process for the preparation of difluoromethyl ether-based derivatives from, for example, aliphatic and aromatic hydroxyl precursors, compositions comprising these compounds and their use, in particular as precursors for medicines for the treatment of diseases, disorders or conditions. In particular, the present application includes the process of preparing compounds of Formula (I), and compositions and uses thereof:

专利号:EP-3929197-B1
优先权日:2015-08-12
标 题:Intermediates for the synthesis of microbiocidal heterobicyclic derivatives

专利号:US-2015051396-A1
优先权日:2010-11-12
标题 :Substituted pyrazino[2,3-d]isooxazoles as intermediates for the synthesis of substituted pyrazinecarboxamides