CAS: 18197-26-7; Sodium Diformylamide

上下游产品

formamide N-formylformamide N,N-dimethyl-formamideformamidN-Formyl-N-2-oxo-3-(triphenylphosphoranyliden)propylformamid N-(2-(2,4-dimethylphenyl)-2-oxoethyl)formamide 12H13NO3C12H13NO3 2-Amino-1-(2,4-dimethyl-phenyl)-ethanone; hydr°Chloride

N-甲酰基m基甲酰胺置于sodium Methylate体系中,用 四氢呋喃 用作溶剂,化学反应 6.0H,以97%的收率获得二甲酰氨基钠
参考文献:共振稳定酰胺的盐和离子液体
标题:共振稳定酰胺的盐和离子液体
摘要:在此基础上,讨论了共振稳定酰胺(例如二甲酰胺(dfa),甲酰基氰酰胺(fca),硝基氰酰胺(nca))的碱金属盐的合成,结构和键合.实验和理论数据.K(18-冠-6)的第一结构报告+ Dfa-,K(18-冠-6)+ Fca-,钠+ Nca-和li(tmeda)+ Dca-被提出.通过x射线数据检查,可以发现几乎平面的阴离子具有强的阳离子-阴离子相互作用,从而形成固态的网络状结构.为了进行比较,还讨论了共价键合的苯基二氰胺和二甲酰胺的x射线结构.通过热分析实验研究了这些酰胺的碱金属盐的热行为.此外,已经制备了几种基于共振稳定酰胺的新型离子液体并进行了充分表征,分别是emim(1-乙基-3-甲基咪唑鎓),Bmim(1-3丁基-3-甲基咪唑)的dfa,Fca和nca盐.甲基咪唑鎓)和hmim(1-己基-3-甲基咪唑鎓).他们大多是在室温下是液体,除了bmim + Fca-在32oc熔
Doi:10.1002/asia.200900181

专利信息

专利号:EP-2703383-A1
优先权日:2012-08-27
标 题:Process for the preparation of agomelatine
发明人：BAROZZA ALESSANDRO; VERONESE MARTINO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of Agomelatine (1), N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide from ethyl 2-(7-methoxynaphthalen-1-yl)acetate (4).n n Said synthesis method is particularly advantageous compared with known procedures because it uses low-cost reagents under mild reaction conditions and allows the isolation of a product with excellent yields and quality.

专利号:US-5907058-A
优先权日:1998-07-29
标题:Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters
发明人：MOENS LUC
权利人:MIDWEST RESEARCH INST
摘要:A process of preparing an acid addition salt of delta-aminolevulinic acid comprising: n dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures thereof to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing said alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.

专利号:US-6583317-B1
优先权日:2000-10-18
标 题 :Synthesis of acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters
发明人：MOENS LUC
权利人:MIDWEST RESEARCH INST
摘要:A process of preparing an acid addition salt of delta-aminolevulinc acid comprising:a) dissolving a lower alkyl 5-bromolevulinate and hexamethylenetetramine in a solvent selected from the group consisting of water, ethyl acetate, chloroform, acetone, ethanol, tetrahydrofuran and acetonitrile, to form a quaternary ammonium salt of the lower alkyl 5-bromolevulinate; andb) hydrolyzing the quaternary ammonium salt with an inorganic acid to form an acid addition salt of delta-aminolevulinic acid.

专利号:EP-0522956-B1
优先权日:1991-07-08
标 题 :Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom
发明人：HARRINGTON PETER J; SANCHEZ IGNACIO H
权利人:SANOFI SA
摘要:Compounds of the formulae: and wherein: R<1>, R<2>, R<3> and R<4> are independently hydrogen, lower alkyl of one to six carbon atoms, aryl or substituted aryl; are advantageously converted to isocyanurate compounds, 2-(2-thienyl)ethylamine compounds and thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.

专利号:US-2022259212-A1
优先权日:2019-07-11
标题:Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase
发明人：BOSS CHRISTOPH; CREN SYLVAINE; KIMMERLIN THIERRY; LOTZ-JENNE CARINA; POTHIER JULIEN; TIDTEN-LUKSCH NAOMI
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in the treatment of inter alia cancer is disclosed.

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.