CAS: 17064-47-0; 2-([1,1'-Biphenyl]-4-yl)-6-Phenylbenzo[d]Oxazole

专利信息

专利号:US-6022684-A
优先权日:1996-10-07
标 题:Fungal IPC synthase assay
发明人：RADDING JEFFREY; DICKSON ROBERT C; LESTER ROBERT L
权利人:UNIV KENTUCKY RES FOUND; LILLY CO ELI
摘要:The presently-disclosed IPC synthase-inhibitor assays comprise the steps of: (1) expression of the IPC1 gene in a cell; (2) introducing labeled starting substrates for ceramide conversion as well as potential inhibitor(s) of such conversion to the expressed gene product in an environment which allows time and conditions for conversion, and (3) identifying those potential inhibitors which actually inhibit conversion. The present invention also provides methods to determine the ability of a test compound to inhibit fungal growth, comprising the steps of (1) presenting active inositolphosophotidylceramide synthase in a manner such that synthesis of inositolphosphotidylceramide can occur; (2) introducing ceramide and phosphotylinositol, said ceramide or phosphatidylinositol carrying label for identification; (3) subjecting said active inositolphosophotidylceramide synthase, ceramide and phosphotylinositol to ordinary conditions necessary for ceramide conversion to phosphoinositol ceramide; and (4) identifying those test compounds which inhibit ceramide conversion to phosphoinositol ceramide.

专利号:CA-2391966-A1
优先权日:1999-11-24
标题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries

专利号:CA-2843908-A1
优先权日:2011-08-02
标题 :Oligosaccharides and oligosaccharide-protein conjugates derived from clostridium difficile polysaccaride ps-i, methods of synthesis and uses thereof, in particular as vaccines anddiagnostic tools