CAS: 15264-63-8; 5-(Pyridin-4-yl)-1,3,4-Oxadiazole-2-Thiol

该化合物是一种杂交循环化合物,其特点是有环和牛二氮酸混合物,有助于其独特的化学特性.该化合物具有硫醇功能组,增强了其反应能力和形成金属复合体的潜力.该化合物在室温中一般是固体,在极地有机溶剂中可能表现出中等溶解性.该丙烯基化合物组的存在可以传播基本性,而该异丙醇组可能有助于其稳定性和进行各种化学反应的潜力,例如核脑哲学替代或与金属离子的协调.该化合物对各个领域,包括医药化学和材料科学具有兴趣,因为它具有生物活动潜力,并且有能力作为协调化学的离子体.其特性可能受到诸如pH,溶剂和温度等因素的影响,使它成为在不同化学环境中进行研究和应用的多种组合.

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1024183-19-4 477856-82-9 64001-70-3

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CAS号75-15-0 二硫化碳 | CAS号54-85-3 异烟肼 | CAS号55-22-1 异烟酸 | CAS号61019-32-7 (2-(pyridine-4-... | CAS号1570-45-2 异烟酸乙酯 | CAS号66528-28-7 N'-(pyridine-4-... | CAS号14254-57-0 异烟酸酰氯 | CAS号36209-51-5 4-氨基-5-吡啶-4H-三唑硫醇 | CAS号2845-82-1 5-(吡啶-4-基)-1,3,... | CAS号84249-74-1 3-(anilinomethy... | CAS号478482-75-6 GSK-3抑制剂II | CAS号64001-70-3 2-(吡啶-4-基)-1,3,4-噁二唑

合成工艺路线路线简述

    📜异烟酸甲酯置于一水合肼体系中,用 乙醇 用作溶剂,化学反应 8.0H,反应生成5-(4-吡啶基)-1,3,4-二唑-2-硫醇
    参考文献:4-羟基香豆素基三唑/恶二唑作为新型抗癌剂的合成
    标题:4-羟基香豆素基三唑/恶二唑作为新型抗癌剂的合成
    摘要:一系列新型 3-取代-4-羟基香豆素7和8,含有 (5-Aryl-1,3,4-Oxadiazol-2-yl)Thio 或 (4-Amino-5-Aryl-4 H-1,2,4-Triazol-3-yl)Thio 部分已被合成并评估为抗癌剂.化合物对肝细胞癌 (Hepg2),乳腺癌 (Mcf7) 细胞和具有上皮形态的人结肠直肠腺癌细胞系 (Ht29) 的体外 Mtt 测定表明,Hepg2 细胞对测试化合物具有更高的敏感性.事实上,所有化合物(除了7B,7C,7G和8G)都比标准药物多柔比星对 Hepg2 细胞更有效(ic50 个值 = 1.65-3.83 μm).虽然,恶二唑类似物7H针对 Hepg2 (Ic 50 =1.65 μm)获得了更好的结果,但n-氨基三唑衍生物8C,8E,8F和8H的 Ic 50值为 1.78-6.34 μm所有测试的细胞系.4-羟基香豆素8非常好的药物样特性以及
    Doi:10.1002/cbdv.202200043

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    专利信息


    专利号:US-4894380-A
    优先权日:1987-04-03
    标题:2-mercapto-5-pyridyl-1,3,4-oxadiazoles and 2-mercapto-5-pyridyl-1,3,4-thiadiazoles of the formula I
    发明人：NYFELER ROBERT; ECKHARDT WOLFGANG; BERIGER ERNST; KRISTIANSEN ODD
    权利人:CIBA GEIGY CORP
    摘要:The invention relates to 2-mercapto-5-pyridyl-1,3,4-oxadiazoles and 2-mercapto-5-pyridyl-1,3,4-thiadiazoles of the formula I (I) wherein X is oxygen or sulfur, R' is C1-C3alkyl which is substituted by bromine, fluorine, C1-C3alkoxy or cyano; unsubstituted or halogen-substituted C3-C7alkenyl; unsubstituted or halogen-substituted C4-C7alkynyl, R is C1-C3alkyl, unsubstituted C1-C3alkoxy or C1-C3alkoxy which is substituted by halogen or C1-C3alkoxy; unsubstituted or halogen-substituted C3-C7alkenyl; C3-C7alkynyl, C1-C3alkylthio, halogen, cyano, hydroxy, amino or amino which is substituted by one or two C1-C3alkyl groups; or is aminocarbonyl; and n is 0, 1, 2, 3 or 4, to the preparation of the compounds of formula I and to novel intermediates for the synthesis of these compounds. The compounds of formula I have nematicidal properties. The invention further relates to nematicidal compositions which contain at least one compound of formula I as active component, and to methods of using said compounds and of the compositions containing them for controlling nematodes.

    专利号:CN-114907290-B
    优先权日:2021-02-07
    标 题 :A kind of low refractive index fluorine-containing epoxy resin and its synthesis method and application

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    主要参考文献

    [参考文献]: Homan Kang, Et Al. Direct Identification Of On-Bead Peptides Using Surface-Enhanced Raman Spectroscopic Barcoding System For High-Throughput Bioanalysis. Sci Rep. 2015 May 28:5:10144.

    合成参考文献


    参考文献:10.1107/s1600536804001916
    摘要:Du M, Zhao X, Guo J. 5-(4-Pyridyl)-1,3,4-oxadiazole-2(3H)-thione. Acta Crystallogr E Struct Rep Online. 2004 Feb 07;60(3):o327–8. doi: 10.1107/s1600536804001916.
    参考文献:10.1007/978-3-662-65056-1_67
    摘要:Pardasani RT, Pardasani P. Magnetic properties of manganese(II) complex with 5-(4-pyridyl)-1,3,4-oxadiazole-2-thione containing 2,2′-bipyridine. 2022. In: Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 6.
    参考文献:10.1007/978-981-97-5818-0_20
    摘要:Dey P. SORS and SESORS Biomedical Applications. 2024. In: Surface- and Tip-Enhanced Raman Scattering Spectroscopy.
    参考文献:10.1007/s13738-025-03315-8
    摘要:Bibi M, Hafeez F, Suleman M. Oxadiazole derivatives as potent biological active agent: a review. J IRAN CHEM SOC. 2026 Jan;23(1). doi: 10.1007/s13738-025-03315-8.
    参考文献:10.1016/j.ejmech.2012.01.030
    摘要:Siddiqui SM, Salahuddin A, Azam A. Synthesis, characterization and antiamoebic activity of some hydrazone and azole derivatives bearing pyridyl moiety as a promising heterocyclic scaffold. European Journal of Medicinal Chemistry. 2012 Mar;49():411–6. doi: 10.1016/j.ejmech.2012.01.030.
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