CAS: 14630-40-1; Bis(Trimethylsilyl)Acetylene

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1066-54-2 13888-92-1

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1,2,3,4-Tetrakis(Trimethylsilyl)Cyclobuta-1,3-Diene置于正二十四烷体系中,化学反应 1.0H,以100%的收率获得二(三甲基甲硅烷基)乙炔
参考文献:Tetrakis(Trimethylsilyl)Tetrahedrane
标题:Tetrakis(Trimethylsilyl)Tetrahedrane
摘要:Tetrakis(Trimethylsilyl)Tetrahedrane 3 Has Been Synthesized Upon Irradiation Of Tetrakis(Trimethylsilyl)Cyclobutadiene 8,Which Can Be Prepared Either By Thermal Nitrogen Elimination From Trimethylsilyl-[1,2,3-Tris(Trimethylsilyl)-2-Cycloprop-1-Enyl]Diazomethane 7 Or By Mild Oxidation Of Cyclobutadiene Dianion 9 With 1,2-Dibromoethane. The Structural Characterization Of Tetrahedrane 3 Has Been Achieved By X-Ray Crystallography. The Surprising Thermal Stability Of 3-Which Is Stable Up To 300 Degreesc-Is Discussed.
Doi:10.1021/ja020863N

专利信息

专利号:US-2018297925-A1
优先权日:2015-10-12
标题 :Methods for total synthesis of resolvin e1
发明人：JAGTAP PRAKASH
权利人:SALZMAN LOVELACE INVEST LTD
摘要:Methods for total chemical synthesis of Resolvin E1 (RvE1) include Wittig reaction of two compounds having hydroxyl protecting group in the presence of a strong base, removal of the hydroxyl-protecting groups with a deprotecting reagent to produce a compound having an ester group, and hydrolysis of the ester group to obtain RvE1

专利号:US-8722886-B1
优先权日:2012-11-13
标题:Methods for the total chemical synthesis of enantiomerically-pure 7-(2′-trimethylsilyl)ethyl camptothecin
发明人：CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY
权利人:CHEN XINGHAI; HAUSHEER FREDERICK H; MALAKHOV ANDREY; KOCHAT HARRY; BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses and claims five (5) novel, highly efficient synthetic routes for the total synthesis of enantiomerically-pure (i.e., 99%) 7-(2′-trimethylsilyl)ethyl camptothecin (BNP1350; Karenitecin; Cositecan). These aforementioned synthetic schemes are the first to disclose the total syntheses of 7-(2′-trimethylsilyl)ethyl camptothecin using a highly novel direct, non-linear and convergent synthetic strategy which involves annealing the key C7-(trimethylsilyl)ethyl side chain-bearing A ring key synthons to an enantiomerically-pure tricyclic pyridone; rather than through the conventional methodology which incorporates the C7-(trimethylsilyl)ethyl side chain as the final synthetic step on a totally synthesized camptothecin parent compound. The current novel synthetic approaches reported herein since utilize desirably functionalized A-ring with preinstalled trimethyl silyl ethyl side chain, the aforementioned synthetic methodologies have a wider scope of making wide range of pharmaceutically relevant A-ring substituted BNP1350 analogs by substituting desirably functionalized nitro or protected amino phenyl carboxy A-ring as the starting material.

专利号:US-2010159540-A1
优先权日:2007-03-26
标题:Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
发明人：RODRIGUEZ ANA; SPUR BERND
权利人:RODRIGUEZ ANA; SPUR BERND
摘要:Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.

专利号:US-4374291-A
优先权日:1981-11-06
标题:Synthesis of bis(ethynylphenyl) compounds
发明人：LAU KREISLER S Y
权利人:HUGHES AIRCRAFT CO
摘要:Bis(ethynylphenyl) compounds are prepared by an improved synthesis process which increases yield and is suitable for large scale synthesis operations. Aromatic dianilines are diazotized to form aromatic halides that are subsequently coupled with an end-protecting group having acetylenic moieties. The end-protecting groups are subsequently removed leaving the desired diethynyl derivative in quantitative yields.

专利号:US-4183864-A
优先权日:1978-02-21
标题:Cobalt catalyzed steroid synthesis
发明人：FUNK RAYMOND L; VOLLHARDT K PETER C
权利人:U S OF AMERICA HEW SECRETARY
摘要:Steroid compounds obtained by co-oligomerization of a side chain functionalized 1,5-hexadiyne with bis(trimethylsilyl)acetylene catalyzed by cyclopentadiene cobalt dicarbonyl, CpCO(CO) 2 , via intermediate benzocyclobutene formation followed by intramolecular cycloaddition to the sterospecific formation of the steroid nucleus. This constitutes a short steroid synthesis, five steps from commercially available acyclic precursor 1,5-hexadiyne and three steps from 2-methyl-cyclopent-2-enone.

专利号:US-2025288549-A1
优先权日:2022-04-29
标 题:Synthetic process for production of lipoxin b4 and analogues thereof
发明人：REED MARK ANDREW; BROWN CARLA; LEE CHIEN-HSUN FRANK; NIELSEN ALEXANDER JAMES; SIVAK JEREMY
权利人:UNIV HEALTH NETWORK
摘要:The present application provides a synthetic process for production of lipoxin B4 and analogues thereof, which is modular and scalable, thus permitting synthesis of large quantities of LXB 4 and analogues thereof, including radiolabeled analogues. Also provided are intermediate compounds that are useful in the synthetic process for production of lipoxin B4 and analogues thereof.