专利号:EP-1363951-B1 优先权日:2000-12-07 标 题 :Polynuclear complex fe(iii) with pullulan oligomers, process of its obtaining, and pharmaceutical preparations on the basis of the complex 发明人:ILIC LJUBOMIR; RISTIC SUZANA; CAKIC MILORAD; NIKOLIC GORAN; STANKOVIC SLOBODAN 权利人:AD ZDRAVLJE FARMACEUTSKO HEMIJ 摘要:A polynuclear complex of pullulan oligomers of formula (I): wherein n = (100-8200), obtained by process of synthesis of soluble pullulan with insoluble iron (III)-hydroxyde of formula (II): wherein n=(900). The process of synthesis is characterized by technical simplicity and economy. In accordance with suggested process, first of all, preparation of pullulan for synthesis, including its characterization (determination of RG, Mw, Mn, [θ]) is carried out, and subsequently its hydrogenation is carried out in order to eliminate reducing groups, iron(III)-hydroxyde gel is prepared, and synthesis of the complex can start. Obtained complex is afterwards prepared for pharmacological use and it is subjected to the subsequent physical and chemical processes of purification. The preparation obtained in such a way is used for prevention and treatment of syderopenic anemia in human and veterinay medicine.
专利号:WO-2004105985-A1 优先权日:2003-05-29 标 题 :Synthesis of iron-based alloy nanoparticles 发明人:LIU CHAO; YANG XIAOMIN; WELLER DIETER K 权利人:SEAGATE TECHNOLOGY LLC 摘要:A method of forming iron-based alloy nanoparticles is disclosed. A solution containing iron salt, noble metal salt and a reducing reagent is heated, resulting in the precipitation of monodispersed nanoparticles such as FePt and FePd. The solution may also include a surfactant. After deposition, the iron-based alloy nanoparticles may be annealed in order to produce the desired crystal structure and magnetic properties. The annealed nanoparticles may comprise FePt having an L10 crystal structure and high magnetic coercivity. The magnetic iron-based nanoparticles are suitable for use in applications such as magnetic recording media, permanent magnet materials and magneto-transport systems.
专利号:US-2024285670-A1 优先权日:2021-06-11 标题 :Therapeutic treatment of tumors by blocking the heme synthesis-export axis 发明人:TOLOSANO EMANUELA; FIORITO VERONICA; PETRILLO SARA; CHIABRANDO DEBORAH; ALLOCCO ANNA LUCIA; BERTINO FRANCESCA 权利人:UNIV DEGLI STUDI DI TORINO 摘要:A blocker of heme synthesis-export axis as active agent for use in the treatment of a tumor in a subject, wherein the blocker of heme synthesis-export axis upmodulates oxidative metabolism of tumor cells by upregulating the tricarboxylic acid (TCA) cycle and the oxidative phosphorylation (OXPHOS).
专利号:US-6486221-B2 优先权日:2000-01-04 标 题:Activation of hydrocarbon synthesis catalysts with hydrogen and ammonia 发明人:LAPIDUS ALBERT L VOVICH; KRYLOVA ALLA JURIEVNA 权利人:EXXONMOBIL RES & ENG CO 摘要:A hydrocarbon synthesis catalyst is formed by contacting the catalyst precursor with a reducing gas comprising a mixture of hydrogen reducing gas and ammonia, at elevated temperature and pressure effective for conventional hydrocarbon synthesis catalyst formation by reduction in hydrogen.
专利号:WO-0149809-A1 优先权日:2000-01-04 标 题:Hydrocarbon synthesis catalyst enhancement with hydrogen and ammonia 发明人:LAPIDUS ALBERT L VOVICH; KRYLOVA ALLA JURIEVNA 权利人:EXXON RESEARCH ENGINEERING CO 摘要:Hydrocarbon synthesis catalysts are enhanced to improved performance, by contacting the catalyst with a reducing gas comprising a mixture of hydrogen and ammonia, at elevated temperature and pressure effective for conventional synthesis catalyst reduction. It is preferred that a portion of the total reduction be achieved with a reducing gas comprising ammonia and hydrogen and the balance with a hydrogen reducing gas without ammonia.
专利号:US-11472844-B2 优先权日:2017-12-11 标题:Peptidomimetics, method of synthesis and uses thereof 发明人:MARTEYN BENOIT SEBASTIEN; COIC YVES-MARIE; BALEUX FRANCOISE 权利人:PASTEUR INSTITUT; INST NAT SANTE RECH MED; CENTRE NAT RECH SCIENT 摘要:The invention relates to a peptidomimetic comprising or consisting of a D amino-acid sequence having at least 75% identity with SEQ ID NO: 1 or SEQ ID NO: 2, or variants or fragments thereof, in particular a peptidomimetic having the capability to interact at least with: neutrophils and/or neutrophil granules, and/or lactoferrin, and/or globet-cells and/or Muc2 proteins, and/or mucus and/or airway sputum. The peptidomimetic may have the capacity to adopt a multimeric, especially a trimeric, organization, and can be labelled, or associated with a reporter or a carrier entity, or associated with an active molecule. The invention also relates to a Solid-Phase Synthesis method for synthesizing a peptidomimetic of the invention, compositions comprising the same and use of the peptidomimetics as a medicamentor an inflammation marker or a neutrophilic inflammation marker. The invention also relates to the use of a peptidomimetic as a probe or marker for staining purposes, or to detect mucus production, or neutrophils, or to detect or monitor diseases or conditions, especially neutrophilic inflammation. The invention also relates to the use of a polypeptide comprising or consisting of SEQ ID NO: 3, or variants or fragments thereof, as probe or marker for staining lactoferrin, in particular neutrophil lactoferrin, or a probe or marker for investigating neutrophilic inflammation, especially in an imaging method.
[参考文献]: Vesna D. Nikolić, Et Al. The Synthesis And Characterization Of Iron(Ii): Gluconate. Advanced Technologies. 3(2) (2014) 16-24. [参考文献]: Zlotkin S, Et Al. Treatment Of Anemia With Microencapsulated Ferrous Fumarate Plus Ascorbic Acid Supplied As Sprinkles To Complementary (Weaning) Foods. Am J Clin Nutr. 2001 Dec;74(6):791-5. [参考文献]: Zlotkin S, Et Al. Use Of Microencapsulated Iron(Ii) Fumarate Sprinkles To Prevent Recurrence Of Anaemia In Infants And Young Children At High Risk. Bull World Health Organ. 2003;81(2):108-15. [参考文献]: Ekhard E Ziegler, Et Al. Dry Cereals Fortified With Electrolytic Iron Or Ferrous Fumarate Are Equally Effective In Breast-Fed Infants. J Nutr. 2011 Feb;141(2):243-8. [参考文献]: Ekhard E Ziegler, Et Al. Iron Supplementation Of Breastfed Infants. Nutr Rev. 2011 Nov:69 Suppl 1:S71-7.
合成参考文献
摘要:Compound: 2-Butenedioic acid (2E)-, iron(2+) salt (1: )