CAS: 122833-60-7; N,N'-((1R,2R)-Cyclohexane-1,2-Diyl)Bis(1,1,1-Trifluoromethanesulfonamide)
该化合物是一种具有硬性环已烷基脊柱和三氟甲基组特征的手性双硫烷衍生物,该化合物以其高立体化学纯度而著称,源自(1R,2R)-环己二氨基鱼叉,使其在不对称合成和催化中具有价值.三氟甲基组的存在增强了其电子回收特性,提高了核循环替代和混合反应的再活性.在各种条件下其稳定性和与有机金属试剂的兼容性进一步扩大了其在制药和精细化学应用中的效用.该化合物的完善结构和功能组使它成为构建复杂分子框架的多功能介质.
- 英文名称N,N'-((1R,2R)-Cyclohexane-1,2-Diyl)Bis(1,1,1-Trifluoromethanesulfonamide)
- 中文名称(1R)-反-N,N′-1,2-环己二基双(1,1,1-三氟甲磺酰胺)
- IUPAC名称N,N'-((1R,2R)-cyclohexane-1,2-diyl)bis(1,1,1-trifluoromethanesulfonamide)
- 其它别名(1R)-Trans-N N'-1 2-Cyclohexanediylbis-&; (R,R)-1,2-Bis(Trifluoromethanesulfonamido)Cyclohexane; (1R,2R)-N,N'-Bis(Trifluoromethanesulfonyl)-1,2-Cyclohexanediamine; (1R,2R)-Trans-N,N′-1,2-Cyclohexanediylbis(1,1,1-Trifluoromethanesulfonamide); N,N'-(1R,2R)-1,2-Cyclohexanediylbis[1,1,1-Trifluoromethanesulfonamide]; N,N'-(1R,2R)-1,2-Cy; Methanesulfonamide,N,N'-(1R,2R)-1,2-Cyclohexanediylbis[1,1,1-Trifluoro-
- CAS编号122833-60-7
- MFCD编号:MFCD01863491
- EINECS号:623-938-8
- 分子式:C8H12F6N2O4S2分子量:378.32
- 产品CID: 330104
- 产品分类有机原料 → 氨基化合物 → 酰胺类化合物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号358-23-6 三氟甲磺酸酐 | CAS号20439-47-8 (1R,2R)-(-)-1,2-环己二胺 | CAS号421-83-0 三氟甲烷磺酰氯合成工艺路线路线简述
📜三氟甲磺酸酐,反式-1,2-环己二胺 以60%的收率获得
参考文献:Ostwald Roswitha,Chavant Pierre-Yves,Stadtmueller Heinz,Knochel Paul,J. Org. Chem.,59 (1994) N 15,S 4143-4153
标题:Ostwald Roswitha,Chavant Pierre-Yves,Stadtmueller Heinz,Knochel Paul,J. Org. Chem.,59 (1994) N 15,S 4143-4153
海关参考信息
- 2921211000-乙二胺
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-6777580-B2
优先权日:1999-07-01
标题:Process for the synthesis of (R)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation
发明人：DEVINE PAUL; KARL HANSEN
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.
专利号:US-8236976-B2
优先权日:2004-03-09
标 题 :Processes for highly enantio- and diastereoselective synthesis of acyclic epoxy alcohols and allylic epoxy alcohols
发明人：WALSH PATRICK; LURAIN ALICE E; KELLY ANN R; MAESTRI AARON G
权利人:WALSH PATRICK; LURAIN ALICE E; KELLY ANN R; MAESTRI AARON G; UNIV PENNSYLVANIA
摘要:The inventive subject matter relates to novel processes for making an epoxy alcohol from an aldehyde, comprising the steps of: (a) adding (i) an organozinc compound or (ii) divinylzinc compound and an diorganozinc compound to said aldehyde in the presence of a first catalyst to form an allylic alkoxide compound; and (b) epoxidizing said allylic alkoxide compound in the presence of an oxidant and a second catalyst.
专利号:US-7429616-B2
优先权日:2005-07-15
标 题 :Synthesis and complete stereochemical assignment of psymberin/irciniastatin for use as antitumor compounds
发明人：BRABANDER JEF DE; JIANG XIN
权利人:UNIV TEXAS
摘要:The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers: n nThe invention further provides processes for making the compounds, their synthetic intermediates, and for methods of using the compounds and their pharmaceutical compositions for the treatment of neoplastic diseases.
专利号:US-2003153760-A1
优先权日:1999-07-01
标 题 :Process for the synthesis of (R)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation
专利号:US-2009163728-A1
优先权日:2004-03-09
标题 :Processes for Highly Enantio- and Diastereoselective Synthesis of Acyclic Epoxy Alcohols and Allylic Epoxy Alcohols
专利号:CN-1358163-A
优先权日:1999-07-01
标题:Method for the synthesis of (R)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Goldfuss, B., Science of Synthesis: C-1 Building Blocks in Organic Synthesis, (2013) 1, 429.
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