CAS: 121577-32-0; 1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(3-Methylpiperazin-1-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride
该化合物是一种化学化合物,是五氟丙酮抗生素的衍生物,其特点是能够抑制细菌DNA gyraase 和Topo异构体Asse IV,这是细菌DNA复制和转录的关键酶.Gatifloxinacid通常用于治疗各种细菌感染,特别是影响呼吸道和尿道系统的感染.复合物显示出广泛频谱的抗菌活动,使其能有效对抗克氏阳性和克丁阴性细菌.就其物理特性而言,Gatifloxacid一般在水中溶解,在标准条件下具有中度稳定性.其药理学特征包括潜在的副作用,其中可能包括胃肠紊乱和...
- 英文名称1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(3-Methylpiperazin-1-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid Hydrochloride
- 中文名称加替沙星盐酸盐
- IUPAC名称1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
- 其它别名1-Cyclopropyl-6-Fluoro-8-Methoxy-7-(3-Methyl-1-Piperazinyl)-4-Oxo-3-Quinolinecarboxylic Acid Hydrochloride; Gatifloxacin Hyd
- CAS编号121577-32-0
- MFCD编号:MFCD09838901
- FDA UNII编号:C3J4S9UD4E
- 分子式:C19H23ClFN3O4分子量:411.86
- 产品CID: 297594
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
合成工艺路线路线简述
📜在 盐酸体系中,用 水 用作溶剂,化学反应 4.0H,以93.2%的收率获得加替沙星盐酸盐
参考文献:喹诺酮羧酸衍生物或二氮杂萘酮羧酸衍生物的制备方法
标题:喹诺酮羧酸衍生物或二氮杂萘酮羧酸衍生物的制备方法
摘要:本发明属于医药化工领域,涉及喹诺酮羧酸衍生物或二氮杂萘酮羧酸衍生物的制备方法,具体涉及7‑取代‑3‑喹诺酮羧酸衍生物或7‑取代‑1,5‑二氮杂萘酮羧酸衍生物的制备方法.所述的制备方法包括如下步骤:(1)在有机溶剂中,将硼螯合物ii与有机胺iii在有机硅化合物下发生偶联反应,得到化合物iv;(2)将化合物iv与盐酸混合,随后过滤分离沉淀的化合物i.本发明所述制备方法相比于传统方法,它条件更为温和,能够减少底物喹啉羧酸硼酸酯的水解,同时避免了副产物hf对产品纯度的影响,收率高,纯度高,使用有机硅相比于传统的碱,更适合用于7‑取代‑3‑喹诺酮羧酸衍生物或7‑取代‑1,5‑二氮杂萘酮羧酸衍生物的工业制备.
海关参考信息
- 2905110000-甲醇
2912110000-甲醛
2915110000-甲酸
2921211000-乙二胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8198451-B2
优先权日:2006-11-13
标题 :Process for the synthesis of moxifloxacin hydrochloride
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR; GANGRADE MANISH; KANATHALA SHASHIREKHA
权利人:RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; PATHI SRINIVAS LAXMINARAYAN; PUPPALA RAVIKUMAR; GANGRADE MANISH; KANATHALA SHASHIREKHA; CIPLA LTD
摘要:A new polymorph of moxifloxacin hydrochloride is described, together with a method for making the polymorph. In addition, new intermediates in the formation of moxifloxacin hydrochloride are described, having formulas (1) and (II):
专利号:US-2008188658-A1
优先权日:2002-08-14
标题 :Novel synthesis of gatifloxacin
专利号:US-2007072868-A1
优先权日:2002-08-14
标 题:Novel synthesis of gatifloxacin
专利号:AU-2007320997-B2
优先权日:2006-11-13
标题:Process for the synthesis of moxifloxacin hydrochloride
专利号:CA-2495271-A1
优先权日:2002-08-14
标题:Synthesis of gatifloxacin
专利号:US-2010152229-A1
优先权日:2006-11-13
标题:Process for the Synthesis of Moxifloxacin Hydrochloride
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主要参考文献
参考标题:Process For The Synthesis Of Moxifloxacin Hydrochloride摘要:A New Polymorph Of Moxifloxacin Hydrochloride Is Described, Together With A Method For Making The Polymorph. In Addition, New Intermediates In The Formation Of Moxifloxacin Hydrochloride Are Described, Having Formulas (1) And (II):
合成参考文献
参考文献:10.1007/12_2022_121
摘要:Hamedi H, Moradi S, Tonelli AE. External Stimuli Responsive Nanofibers in Biomedical Engineering. 2022. In: Advances in Polymer Science.
参考文献:10.1007/s13369-024-09075-6
摘要:Çerçi A, Demir ES, Karaca E, Güzel ÇB, Osman B. Preparation and Characterization of Amoxicillin-Loaded Polyvinyl Alcohol/Sodium Alginate Nanofibrous Mat: Drug Release Properties, Antibacterial Activity, and Cytotoxicity. Arab J Sci Eng. 2024 May 10;50(1):77–91. doi: 10.1007/s13369-024-09075-6.
参考文献:10.1007/s42765-025-00539-4
摘要:Yu Y, Zhang F, Liu Y, Leng J. Smart Polymer Fibers: Promising Advances in Microstructures, Stimuli-Responsive Properties and Applications. Adv. Fiber Mater. 2025 Apr 11;7(4):1010–41. doi: 10.1007/s42765-025-00539-4.
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