CAS: 1198-84-1; 2-Hydroxy-2-(4-Hydroxyphenyl)Acetic Acid

该化合物是甲状腺酸的氢氧化衍生物,其成分为碳酸和苯丙基氢氧基组,该化合物是有机合成的多种中间体,特别是在生产药品,农用化学品和特殊化学品方面,其双功能结构能够参与诸如酯化,氧化和凝聚等反应,使其对合成手性化合物或生物活性分子具有价值. 苯丙基组增强了其在电子哲学替代中的再活动性,而氨基酸则允许进一步衍生. 4-Hydroxymandicolation在代谢途径和精细化化学制造中的前体方面的潜在作用也得到了研究.

结构式图片

相似化合物

184901-84-6 10502-44-0 20714-89-0

上下游产品

Alpha,4-二羟基苯乙酸甲酯 Methyl P-Hydroxymandelate 68758-69-0
4-羟基扁桃酸乙酯 Ethyl 4-Hydroxymandelate 68758-68-9
扁桃酸 Mandelic Acid 90-64-2
4-羟基苯乙酸甲酯 Methyl 4-Hydroxyphenylacetate 14199-15-6
Methyl 2-(4-Aminophenyl)-2-Hydroxyacetate 182918-73-6
4-羟基苯基乙醛酸 Pisolithin A 15573-67-8

合成工艺路线路线简述

    📜Benzoyloxy-(4-Benzoyloxy-Phenyl)-Acetonitrile置于盐酸,Sodium Hydroxide体系中,化学反应生成4-羟基扁桃酸
    参考文献:Aloy; Rabaut,Bulletin De La Societe Chimique De France,1912,Vol. <4> 11,P. 390
    标题:Aloy; Rabaut,Bulletin De La Societe Chimique De France,1912,Vol. <4> 11,P. 390

    海关参考信息

    专利信息


    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:CN-113355367-B
    优先权日:2018-03-22
    标题 :Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid

    专利号:CN-108410831-B
    优先权日:2018-03-22
    标题:Ketoacid reductase, gene, engineering bacterium and application in synthesis of chiral aromatic 2-hydroxy acid

    专利号:WO-2006053688-A1
    优先权日:2004-11-17
    标 题:Cosmetic and dermatological preparations for the treatment of mature skin
    发明人:DOERING THOMAS
    权利人:HENKEL KGAA; DOERING THOMAS
    摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Li Ff, Et Al. Engineering Escherichia Coli For Production Of 4-Hydroxymandelic Acid Using Glucose-Xylosemixture. Microb Cell Fact. 2016 May 27;15:90.

    合成参考文献


    摘要:Parmeggiani, F.; Galman, J. L.; Montgomery, S. L.; Turner, N. J., Science of Synthesis, (2019) , 403.
    参考文献:10.1007/pl00007050
    摘要:Yamamoto T, Yokotani-Tomita K, Kosemura S, Yamamura S, Yamada K, Hasegawa K. Allelopathic Substance Exuded from a Serious Weed, Germinating Barnyard Grass (Echinochloa crus-galli L.), Roots. Journal of Plant Growth Regulation. 1999 Oct;18(2):65–7. doi: 10.1007/pl00007050.
    参考文献:10.1021/bi035762w
    摘要:Gunsior M, Ravel J, Challis GL, Townsend CA. Engineering p-hydroxyphenylpyruvate dioxygenase to a p-hydroxymandelate synthase and evidence for the proposed benzene oxide intermediate in homogentisate formation. Biochemistry. 2004 Jan 27;43(3):663–74. doi: 10.1021/bi035762w.
    参考文献:10.1186/1471-2164-9-271
    摘要:Lee KB, De Backer P, Aono T, Liu CT, Suzuki S, Suzuki T, Kaneko T, Yamada M, Tabata S, Kupfer DM, Najar FZ, Wiley GB, Roe B, Binnewies TT, Ussery DW, D'Haeze W, Herder JD, Gevers D, Vereecke D, Holsters M, Oyaizu H. The genome of the versatile nitrogen fixer Azorhizobium caulinodans ORS571. BMC Genomics. 2008 Jun 04;9():271.
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