CAS: 1060812-84-1; 5-Bromopyrazolo[1,5-A]Pyridine
该化合物是一种环环环的杂交有机化合物,其特点是其引信有线虫和环,在环形环的5处放置有溴替代物,该化合物通常呈现黄色至褐色的灰色,溶于二甲基硫氧化物和二甲基芳基胺(DMF)等有机溶剂,因其潜在的生物活动而闻名于此,使其对药用化学和药物开发具有兴趣,溴原子的存在可影响其再活动以及与生物目标的相互作用.此外,该复合物还可能呈现荧光性或光化等特性,取决于其分子结构和环境,其合成通常涉及多步反应,包括卤化和循环过程.与许多外生循环一样,它可能参与各种化学反应,其中包括核循环替代和电药用芳香替代,使其成为有机合成的多功能建筑块.由于具有潜在的毒性和再活动性,应当遵守安全和谨慎措施.
- 英文名称5-Bromopyrazolo[1,5-A]Pyridine
- 中文名称5-溴吡唑并[1,5-a]吡啶
- IUPAC名称5-bromopyrazolo[1,5-a]pyridine
- 其它别名5-溴吡唑并[1,5-A]吡啶5-Bromopyrazolo[1,5-A]Pyridine; 5-Bromopyrazolo[1,5-A]Pyridine(1060812-84-1)
- CAS编号1060812-84-1
- MFCD编号:MFCD13189494
- EINECS号:837-270-1
- 分子式:C7H5BrN2分子量:197.03
- 产品CID: 101988
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡唑类化合物
相似化合物
1520497-11-3 1264193-11-4 5910-12-3MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
📜4-溴吡啶置于硫酸,2,4,6-三甲基苯磺酰羟胺体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 38.0H,反应生成5-溴吡唑并[1,5-A]吡啶
参考文献: Compounds And Compositions For The Treatment Of Parasitic Diseases[fr] Composés Et Compositions Pour Le Traitement De Maladies Parasitaires
标题: Compounds And Compositions For The Treatment Of Parasitic Diseases[fr] Composés Et Compositions Pour Le Traitement De Maladies Parasitaires
摘要:本发明提供了化合物的公式i:[在此插入公式]或其药学上可接受的盐,互变异构体或立体异构体,其中变量如本文所定义.本发明还提供了包含这种化合物的药物组合物以及使用这种化合物用于治疗,预防,抑制,改善或根除由疟原虫引起的疾病的病理学和/或症状学的方法,例如疟疾.
专利信息
专利号:WO-2025128848-A1
优先权日:2023-12-12
标题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).
专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.
专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.
专利号:US-2018222892-A1
优先权日:2012-07-03
标 题 :Heterocyclic modulators of lipid synthesis
专利号:EP-3083583-B1
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
专利号:CA-2934251-A1
优先权日:2013-12-20
标题:A combination of heterocyclic modulators of lipid synthesis and chemotherapeutic drugs in treatment of cancer
