CAS: 87-91-2; (2R,3R)-Diethyl 2,3-Dihydroxysuccinate

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13811-71-7 4136-22-5 622-00-4

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CAS号64-17-5 乙醇 | CAS号87-69-4 酒石酸 | CAS号57968-71-5 DL-酒石酸二乙酯 | CAS号81-23-2 去氢胆酸 | CAS号623-91-6 富马酸二乙酯 | CAS号622-00-4 L-酒石酸二苄酯 | CAS号75-03-6 碘乙烷 | CAS号608-89-9 ethyl hydrogen ... | CAS号10302-94-0 (Z)-2-氯-2-丁烯二酸二乙酯 | CAS号1122-17-4 2,3-二氯顺酐 | CAS号37031-29-1 (-)-二甲基-2,3-邻异丙... | CAS号50622-09-8 (+)-2,3-O-异亚丙基-L-苏糖醇 | CAS号924-44-7 乙醛酸乙酯 | CAS号2319-57-5 L-苏丁醇 | CAS号2217-15-4 L-(+)-酒石酸二异丙酯 | CAS号88393-56-0 (+)-L-酒石酸二苄酰胺 | CAS号59779-75-8 (R,R)-O,O-异丙基酒石酸二乙酯 | CAS号608-68-4 L-(+)-酒石酸二甲酯

L-酒石酸置于盐酸体系中,用 乙醇 作为反应溶剂,化学反应生成 L-(+)-酒石酸二乙酯
参考文献:2-甲酰基吡咯螺酮天然产物阿考他汀a的收敛合成
标题:2-甲酰基吡咯螺酮天然产物阿考他汀a的收敛合成
摘要:报道了从中药蒺藜中分离的吗啉-螺酮天然产物 Acortatarin A 的简洁灵活的合成方法.关键步骤涉及衍生自 D-甘露醇的胺与二氢吡喃酮的美拉德型缩合.该方法还能够获得用于生物学评价的 Acortatarin A 类似物,并可应用于相关 2-甲酰基吡咯天然产物的合成.
DOI:10.1055/s-0031-1290508

专利信息

专利号:US-5948789-A
优先权日:1994-07-15
标题:Process for synthesis of substituted sulphoxides
发明人：LARSSON MAGNUS ERIK; STENHEDE URBAN JAN; SOERENSEN HENRIK; VON UNGE SVERKER PER OSKAR; COTTON HANNA KRISTINA
权利人:ASTRA AB
摘要:PCT No. PCT/SE95/00818 Sec. 371 Date Jul. 14, 1995 Sec. 102(e) Date Jul. 14, 1995 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/02535 PCT Pub. Date Feb. 1, 1996A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as well as of other structurally related sulphoxides or their alkaline salts. The claimed process is an asymmetric oxidation of a pro-chiral sulphide to the single enantiomers or an enantiomerically enriched form of the corresponding sulphoxide. The application also claims the enantiomeric sulphoxide products produced by the process and their use in medicine.

专利号:US-8697880-B2
优先权日:2004-02-20
标 题 :Compounds useful for the synthesis of S- and R-omeprazole and a process for their preparation
发明人：VON UNGE SVERKER; FREGLER CHRISTINA
权利人:UNGE SVERKER VON; FREGLER CHRISTINA; ASTRAZENECA AB
摘要:The present invention relates to an improved method for the synthesis of the (S)- or (R)-enantiomer of omeprazole, characterized in that 2-[[(4-X-3,5-dimethylpyridin-2-yl)methyl]thio]-5-methoxy-1H-benzimidazole or 2-[[(4-X-3,5-dimethyl-1-oxidopyridin-2-yl)methyl]thio]-5-methoxy-1H-benzimidazole, wherein X is a leaving group, is oxidized into the corresponding sulphoxide which is obtained as a crystalline compound. Recrystallization of the thus obtained sulphoxide results in a compound of enhanced chemical and optical purity, which is subsequently transformed into the (S)- or (R)-enantiomer of omeprazole.

专利号:US-5702928-A
优先权日:1994-07-18
标题 :Process for producing optically active triazole compounds and method of racemizing optically active triazole compounds
发明人：KAWADA NAOKI; YAMAZAKI NORITSUGU; IMOTO TAKAFUMI; IKURA KIYOSHI
权利人:DAICEL CHEM
摘要:PCT No. PCT/JP95/01416 Sec. 371 Date May 24, 1996 Sec. 102(e) Date May 24, 1996 PCT Filed Jul. 17, 1995 PCT Pub. No. WO96/02664 PCT Pub. Date Feb. 1, 1996A process for the asymmetric synthesis of a compound represented by general formula (II-R) easily at a low cost by using a lipase, and a process for producing a compound to be utilized in the above synthesis. (II-R)

专利号:US-11365211-B2
优先权日:2018-02-01
标 题 :Stereoselective synthesis and process for the manufacturing of 2′-deoxynucleosides
发明人：ZHANG LIANHAO; VISHNUVAJJALA BABURAO; MORRIS JOEL; BAHDE ROBERT; DENYSENKO SERGIY M; LOPEZ OMAR DIEGO; WISHKA DONN GREGORY
权利人:THE USA AS REPRESENTED BY THE SEC DEP OF HEALTH AND HUMAN SERVICES; ALCHEM LABORATORIES CORP; US HEALTH
摘要:Methods for stereoselective synthesis and manufacturing of 2′-deoxynucleosides, such as 2′-ribonucleosides, are disclosed. In some embodiments, the 2′-deoxynucleoside is a β-anomer of a 2′-deoxynucleoside having a 3′ α hydroxyl, 4′ β hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4′-thio-2′-deoxycytidine (T-dCyd) and 5-aza-4′-thio-2′-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).

专利号:US-7915422-B2
优先权日:2004-10-11
标题:Processes for the preparation of substituted sulfoxides
发明人：KUMAR NEELA PRAVEEN; KHANNA MAHAVIR SINGH; PRASAD MOHAN; KUMAR YATENDRA
权利人:RANBAXY LAB LTD
摘要:The present invention relates to a process for enantioselective synthesis of substituted pyridinylmethyl sulfinyl-benzimidazole of compound of Formula (I). The process includes enantioselective catalytic oxidation of a substituted pyridinylmethyl prochiral sulfide derivative of compound of Formula (II) with an oxidizing agent in the presence of a chiral transition metal complex and a base in the absence of an organic solvent.

专利号:US-7393954-B2
优先权日:2002-12-12
标题:Process for the production of pentostatin aglycone and pentostatin
发明人：NADJI SOURENA; SMOOT JAMES; SAMPATH UMASHANKER
权利人:RELIABLE BIOPHARMACEUTICAL COR
摘要:A novel, scaleable and improved process for preparing pentostatin and its analogs is disclosed. The method comprises the diastereospecific synthesis of the nucleobase from commercially available L-Dialkyl tartarates.