CAS: 773873-77-1; Methyl 5-Bromo-1H-Indole-3-Carboxylate

上下游产品

5-溴-1H-吲哚-3-甲酸 5-Bromo-1H-Indole-3-Carboxylic Acid 10406-06-1
5-溴吲哚-3-甲醛 5-Bromo-1H-Indole-3-Carboxaldehyde 877-03-2

📜在 Manganese(Iii) Triacetate Dihydrate,溶剂黄146体系中,用80%的收率获得产物5-溴吲哚-3-羧酸甲酯
参考文献:锰介导的氧化丙二酸偶联衍生的氮杂富烯中间体的形成和捕获
标题:锰介导的氧化丙二酸偶联衍生的氮杂富烯中间体的形成和捕获
摘要:使用乙酸锰(iii)作为氧化剂进行吲哚/吡咯,丙二酸二甲酯和乙酸的一锅三组分偶联反应.在mn(oac)3存在下,吲哚-2和吲哚-3-羰基化合物分别在3-和2-位烷基化,随后在新形成的苄基碳上发生氧化和亲核捕获.相反,2-和3-吲哚羧酸的氧化提供了相应的2-Oxindol-3-亚烷基和3-Oxindol-2-亚烷基.反应条件,范围和机理在本文中讨论.
DOI:10.1016/j.Tet.2016.03.012

专利信息

专利号:WO-2010008727-A1
优先权日:2008-06-16
标 题:Asymmetric synthesis of allyl or allene oxindoles
发明人：KOZLOWSKI MARISA C; LINTON ELIZABETH CAROL
权利人:UNIV PENNSYLVANIA; KOZLOWSKI MARISA C; LINTON ELIZABETH CAROL
摘要:The invention concerns processes for the preparation of a compound of the formula I comprising contacting a compound of formula II with a catalyst, said catalyst comprises (i) at least one of Pd and Cu and (ii) one or more of diamine, diphosphine and aminophosphine ligands; wherein Z is -C(R 5 )(R 6 )-C(R 2 )=C(R 3 )(R 4 ) and Y is -C(R 3 )(R 4 )-C(R 2 )=C(R 5 )(R 6 ) or Z is -C(R 5 )(R 6 )-C≡C-R 3 ; Y is or -C(R 3 )=C=C(R 5 )(R 6 ); X is NH, NR 15 , O or S; a is O or an integer from 1 to 4 and R 1 -R 7 and R 15 are as defined in the specification.