CAS: 69113-59-3; 3-Iodobenzonitrile

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CAS号696-40-2 3-碘苄胺 | CAS号2237-30-1 3-氨基苯甲腈 | CAS号618-51-9 间碘苯甲酸 | CAS号100-47-0 苯甲腈 | CAS号10388-19-9 间碘苯甲酰胺 | CAS号139-02-6 苯酚钠 | CAS号81447-70-3 m-cyanodiphenyl... | CAS号6952-59-6 间溴苯甲腈 | CAS号108-95-2 苯酚 | CAS号108697-88-7 3-phenylsulfany... | CAS号171290-53-2 3-乙炔基苯甲腈 | CAS号368-77-4 间三氟甲基苯腈 | CAS号443998-73-0 3-(4-氨基苯基)苯甲腈 | CAS号204078-31-9 3-吗啉基苯甲腈 | CAS号25699-85-8 3-(1H-咪唑-1-基)苯甲腈 | CAS号25699-82-5 3-(1H-吡唑-1-基)苯甲腈 | CAS号873-62-1 3-羟基苯腈 | CAS号6136-68-1 3-乙酰苄腈 | CAS号696-41-3 3-碘苯甲醛

间溴苯甲腈置于copper(L) Iodide,(1R,2R)-(-)-N,N'-二甲基-1,2-环己二胺,Sodium Iodide体系中,用 二乙二醇二甲醚,甲苯 作为反应溶剂,化学反应 0.5H,反应生成 间碘苯腈
参考文献:连续流动条件下快速高效的铜催化(杂)芳烃的finkelstein反应
标题:连续流动条件下快速高效的铜催化(杂)芳烃的finkelstein反应
摘要:已经开发出一种使用连续流反应生成各种芳基碘化物的铜催化(杂)芳烃的finkelstein反应的通用,快速,有效的方法.所描述的方法可以耐受各种官能团,包括n-H和o-H基团.另外,代替分离,在两个不同的多步连续流工艺(酰胺化和mg-I交换/亲核加成)中使用了芳基碘溶液,以证明该方法的灵活性.
DOI:10.1002/anie.201409595

专利信息

专利号:US-5039814-A
优先权日:1990-05-02
标 题:Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
发明人：SHUMAN RICHARD F; KING ANTHONY O; ANDERSON ROBERT K
权利人:MERCK & CO INC
摘要:A process utilizes the tetrazole functional group to direct lithiation at the ortho position of a phenyltetrazole and generate a nucleophilic aryllithium species which then undergoes reaction with an electrophile to generate a 2-substituted 1-(tetrazol-5-yl)benzene. The process is useful in the production of intermediates in the synthesis of angiotensin II antagonists. This novel process is a more cost effective and versatile route for the large-scale preparation of these key intermediates.

专利号:WO-2023061999-A1
优先权日:2021-10-12
标 题 :Process for preparing a phenolic hydrocarbon
发明人：CORNELLA JOSEP; LE VAILLANT FRANCK
权利人:STUDIENGESELLSCHAFT KOHLE GGMBH
摘要:The present invention discloses a distinct mode of action of a nickel catalyst to forge C-0 bonds to unlock the mild utilization of N2O as O-atom transfer reagent in the synthesis of complex phenols from the corresponding aryl halides.

专利号:US-11299484-B2
优先权日:2018-10-10
标 题 :Inhibiting fatty acid synthase (FASN)
发明人：MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

专利号:CA-2041620-C
优先权日:1990-05-02
标 题:An ortho-lithiation process for the synthesis of 2-substituted-1-(tetrazol-5-yl) benzenes

专利号:WO-2023283974-A1
优先权日:2021-07-12
标 题:Deuterated ammonia preparation method and deuteration reaction involving same as deuterium source
发明人：LANG JIANPING; GU HONGWEI; ZHU FENGYUAN; NIU ZHENG
权利人:UNIV SOOCHOW
摘要:A deuterated ammonia preparation method and a rapid deuterated reaction involving same as a deuterium source, which belong to the technical field of organic synthesis. The deuterated ammonia preparation method comprises the following steps: passing a nitrile compound through the action of a catalyst under a deuterium source atmosphere to obtain a deuterated amine. In the deuterated ammonia preparation method, a target product can be obtained in one step under mild conditions by means of a simple organic reaction, and the operation is simple; the produced deuterated ammonia can be directly used as a deuterium source, and undergoes a rapid hydrogen-deuterium exchange reaction with active hydrogen to synthesize a corresponding deuterated compound. An active hydrogen-containing compound comprises a hydroxyl compound, a thiol compound, an alkynyl compound, a phenolic compound, a silicon-hydrogen compound or an amino compound. The preparation method has mild reaction conditions and low operation costs and has good universality.