CAS: 6118-51-0; Exo-3,6-Epoxy-1,2,3,6-Tetrahydrophthalic Anhydride

该化合物是在癌症研究领域,研究其抑制肿瘤生长和诱发癌症细胞中流行病的能力.Exo-56-Dehtrontrcantharidin显示有机溶剂的中等溶性,其稳定性可能受到pH和温度等环境条件的影响.该化合物的行动机制被认为涉及细胞过程的中断,使其成为进一步研究医学化学的兴趣对象.然而,由于该化合物具有强大的生物影响,因此必须谨慎地处理该物质,并遵守实验室环境中的安全规程.

结构式图片

相似化合物

5426-09-5 29745-04-8 72150-22-2

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号110-00-9 呋喃 | CAS号108-31-6 顺酐 | CAS号60-29-7 乙醚 | CAS号7732-18-5 水 | CAS号1984-43-6 7-Oxabicyclo(2.... | CAS号108-31-6 顺酐 | CAS号85-44-9 苯酐 | CAS号110-16-7 马来酸 | CAS号110-17-8 富马酸,反丁烯二酸 | CAS号88-99-3 邻苯二甲酸 | CAS号110-00-9 呋喃 | CAS号2902-72-9 2(5H)-Furanone,... | CAS号28871-62-7 外-3,6-环氧-1,2,3,... | CAS号3374-46-7 2-(5-oxo-2-fury...

合成工艺路线路线简述

  • 108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Toluene; 24 H,110 °C
    标题:A Simple Route For The Synthesis Of Novel Norcantharimide Derivatives Via Acidolysis With Hydrochloric Acid(Gas)
    作者:Koese,Aytekin
    参考文献:Journal Of Heterocyclic Chemistry 日期:2021 卷标:58(5) 页码:1171-1178]

    108-31-6 = 6118-51-0
    反应条件:1.1 10 - 15 °C
    标题:Substituted Phthalic Anhydrides From Biobased Furanics: A New Approach To Renewable Aromatics
    作者:Thiyagarajan,Shanmugam; Genuino,Homer C.; Sliwa,Michal; Van Der Waal,Jan C.; De Jong,Ed; Et Al
    参考文献:Chemsuschem 日期:2015 卷标:8(18) 页码:3052-3056]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Diethyl Ether
    标题:Synthesis And Aqueous Ring Opening Metathesis Polymerization Of 7-Oxanorbornene Derivatives
    作者:Lu,Shui-Yu
    参考文献:1991]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Diethyl Ether; Overnight,Rt
    标题:Inverse Electron-Demand Diels-Alder Bioconjugation Reactions Using 7-Oxanorbornenes As Dienophiles
    作者:Agramunt,Jordi; Ginesi,Rebecca; Pedroso,Enrique; Grandas,Anna
    参考文献:Journal Of Organic Chemistry 日期:2020 卷标:85(10) 页码:6593-6604]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Ethyl Acetate; Overnight,Cooled
    标题:Tunable E-Z Photoisomerization In α,β-Peptide Foldamers Featuring Multiple (E/z)-3-Aminoprop-2-Enoic Acid Units
    作者:Marafon,Giulia; Crisma,Marco; Moretto,Alessandro
    参考文献:Organic Letters 日期:2019 卷标:21(11) 页码:4182-4186]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Toluene; 24 H,Reflux
    标题:Synthesis And Anticancer Activity Evaluation Of New Isoindole Analogues
    作者:Kose,Aytekin; Bal,Yildiz; Kishali,Nurhan H.; Sanli-Mohamed,Gulsah; Kara,Yunus
    参考文献:Medicinal Chemistry Research 日期:2017 卷标:26(4) 页码:779-786]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Diethyl Ether; 48 H,38 °C
    标题:Synthesis And Antiproliferative Assay Of Norcantharidin Derivatives In Cancer Cells
    作者:Tu,Guo Gang; Zhan,Jian Feng; Lv,Qiao Li; Wang,Jia Qi; Kuang,Bin Hai; Et Al
    参考文献:Medicinal Chemistry (Sharjah 日期:2014 卷标:10(4) 页码:376-381]

    108-31-6 = 6118-51-0
    反应条件:1.1 1 H,1.7 Bar,Rt
    标题:Renewable Production Of Phthalic Anhydride From Biomass-Derived Furan And Maleic Anhydride
    作者:Mahmoud,Eyas; Watson,Donald A.; Lobo,Raul F.
    参考文献:Green Chemistry 日期:2014 卷标:16(1) 页码:167-175]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Diethyl Ether; 1 H,0 °C; 24 H,Rt
    标题:Versatile Synthesis Of Rac- And Meso-Hydroxymethyl Cyclohexenoids Containing Phenyl Groups: α-/β-Glucosidase Activities,Inhibition Kinetics And Molecular Docking Studies
    作者:Sevmezler,Sedat; Col,Suemeyye; Emirik,Mustafa; Ceylan,Davut; Baran,Arif
    参考文献:European Journal Of Organic Chemistry 日期:2022 卷标:2022(13)]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Diethyl Ether; 12 H,Rt
    标题:Synthesis And Verification Of Biobased Terephthalic Acid From Furfural
    作者:Tachibana,Yuya; Kimura,Saori; Kasuya,Ken-Ichi
    参考文献:Scientific Reports 日期:2015 卷标:5]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Tetrahydrofuran; 48 H,Rt
    标题:Design And Synthesis Of Disodium Phosphate Derivatives Of Norcantharidin
    作者:Zhou,Yue; Cai,Yu-Chen; Zhang,Xue-Jing; Wang,Zhi-Xin; Xian,Li-Jian; Et Al
    参考文献:Journal Of Chinese Pharmaceutical Sciences 日期:2006 卷标:15(1) 页码:28-32]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Diethyl Ether; 48 H,30 °C
    标题:Cantharidin Analogues: Synthesis And Evaluation Of Growth Inhibition In A Panel Of Selected Tumour Cell Lines
    作者:Mccluskey,Adam; Ackland,Stephen P.; Bowyer,Michael C.; Baldwin,Monique L.; Garner,James; Et Al
    参考文献:Bioorganic Chemistry 日期:2003 卷标:31(1) 页码:68-79]

    108-31-6 = 6118-51-0
    反应条件:1.1 12 H,Rt
    标题:Synthesis And Characterization Of A Renewable Polyester Containing Oxabicyclic Dicarboxylate Derived From Furfural
    作者:Tachibana,Yuya; Yamahata,Masayuki; Kasuya,Ken-Ichi
    参考文献:Green Chemistry 日期:2013 卷标:15(5) 页码:1318-1325]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Diethyl Ether; 3 D,Rt
    标题:Modified Norcantharidins Synthesis,Protein Phosphatases 1 And 2A Inhibition,And Anticancer Activity
    作者:Hart,Matthew E.; Chamberlin,A. Richard; Walkom,Cecilia; Sakoff,Jennette A.; Mccluskey,Adam
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2004 卷标:14(8) 页码:1969-1973]

    108-31-6 = 6118-51-0
    反应条件:1.1 Solvents: Toluene; 24 H,Reflux
    标题:Synthesis,Spectroscopic Characterizations Of Novel Norcantharimides,Their Adme Properties And Docking Studies Against Covid-19 Mpr°
    作者:Oezkan,Hamdi; Adem,Sevki
    参考文献:Chemistryselect 日期:2020 卷标:5(18) 页码:5422-5428]

    108-31-6 = 6118-51-0
    反应条件:1.1 3 H,Rt
    标题:A New Synthon For The Synthesis Of Aminoinositol Derivatives
    作者:Cokol,Nalan Korkmaz; Kaya,Serdal; Balci,Metin
    参考文献:Tetrahedron Letters 日期:2017 卷标:58(28) 页码:2732-2735
📜呋喃,马来酸酐 以91%的收率获得exo-3,6-Epoxy-1,2,3,6-Tetrahydrophthalic Anhydride
参考文献:钯催化的[2 + 1]环加成化合物,以亚乙烯基环丙烷作为7元碳环自行车的前体
标题:钯催化的[2 + 1]环加成化合物,以亚乙烯基环丙烷作为7元碳环自行车的前体
摘要:乙酸钯(II)与仲氧化膦结合可为从氧杂降冰片烯衍生物和叔炔丙基酯开始的[2 + 1]环加成反应提供有效的催化体系,从而生成亚乙烯基亚环丙烷.该反应特定于仲膦氧化物生成的二齿次膦基次膦酸配体.发现[2 + 1]环加成的范围广,对各种官能团具有高度耐受性.此外,通过钯催化的扩环,将亚乙烯基环丙烷直接转化为氧杂环[3.2.1] oct-2-烯衍生物.最后,草三环化合物的氧杂桥裂解产生功能化的7元碳环.
Doi:10.1002/Adsc.201500971

海关参考信息

专利信息


专利号:US-2004152905-A1
优先权日:2003-01-31
标题:Universal building blocks and support media for synthesis of oligonucleotides and their analogs
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-9040553-B2
优先权日:2010-09-17
标题:Phenoxyisobutyric acid compounds and method of synthesis
发明人：LALEZARI IRAJ; FABRICANT JILL
权利人:LALEZARI IRAJ; FABRICANT JILL; CELL VIABLE CORP
摘要:The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).

专利号:US-7026511-B2
优先权日:2002-08-30
标 题 :Synthesis of N-vinylformamide
发明人：BECKMAN ERIC J; CHAPMAN TOBY M; FAVERO CEDRICK; CAPELLI CHRISTOPHER C; SWIFT HAROLD E; CARROLL WILLIAM EAMON
权利人:SNF SA
摘要:A process to produce N-vinylformamide includes the steps of: reacting hydroxyethyl formamide with a reactant comprising at least one cyclic anhydride group to form an ester, and dissociating the ester via heat in a thin film evaporation to synthesize N-vinylformamide and a compound comprising at least one diacid group, the N-vinylformamide separating from the diacid during the thin film evaporation. The reactant including at least one cyclic anhydride group can, for example, be succinic anhydride, maleic anhydride, phthalic anhydride, (2-docecen-1-yl)succinic anhydride, exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride or a polymer including at least one cyclic anhydride group. A process to produce N-vinylformamide comprises the steps of: mixing acetaldehyde, formamide and a source of anhydride in a single reaction vessel, reacting the acetaldehyde, formamide and the source of anhydride in the reaction vessel under pressure, dissociating an ester formed by a reaction between the source of anhydride and hydroxyethyl formamide formed in the reaction vessel to synthesize N-vinylformamide and a compound comprising at least one diacid group.

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合成参考文献


摘要:Hof, K.; Lippert, K. M.; Schreiner, P. R., Science of Synthesis: Asymmetric Organocatalysis, (2012) 2, 373.
摘要:Lee, D.; Reddy Sabbasani, V., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 567.
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