CAS: 55881-07-7; Midecamycin Acetate

专利信息

专利号:US-10472663-B2
优先权日:2015-01-21
标 题:Procedure for the rapid determination of bacterial susceptibility to antibiotics that inhibit protein synthesis
发明人：FERNÃ?NDEZ GARCÃ?A JOSÉ LUIS; GOSÃ?LVEZ BERENGUER JAIME; BOU ARÉVALO GERMÃ?N; TAMAYO NOVAS MARIA; SANTISO BRANDARIZ REBECA; OTERO FARIÑA FÃ?TIMA MARÃ?A
权利人:ABM TECH LLC
摘要:The present invention relates to a method for the rapid evaluation of bacterial susceptibility or non-susceptibility of bacteria to antibiotics that inhibit protein synthesis. The rationale is to identify bacterial responses that depend or are influenced by protein synthesis. If this response is prevented or reduced by the antibiotic that inhibits the protein synthesis, the bacteria are susceptible to this antibiotic. Otherwise, if the response keeps similar despite the incubation with the antibiotic, the bacteria are not susceptible or resistant to this antibiotic. These responses could be determined at the DNA lev-el, cell wall level, morphological level or any other experimental approach, including metabolic, bio-chemical, physiological or genetic processes.

专利号:US-5444174-A
优先权日:1992-02-26
标题 :16-membered macrolide derivative having sustained antibacterial activity in plasma, synthesis intermediate thereof and process for producing the same
发明人：AJITO KEIICHI; KURIHARA KENICHI; ISHIZUKA TSUNEO; HARA TETSURO; USUI TAKAYUKI; SHIBAHARA SEIJI
权利人:MEIJI SEIKA KAISHA
摘要:16-membered macrolide compounds wherein both of hydroxyl groups at the 3''- and 4''-positions form ether bonds together with two alkyl groups which are either the same or different from each other is useful as an antibacterial agent. The macrolide compounds represented by formula (I) are prepared by chemically modifying midecamycin A3 to obtain a synthesis intermediate of the formula (II), which is further chemically modified. (I)

专利号:US-8143035-B2
优先权日:2006-09-22
标题 :Pantothenate kinase overexpression and pantothenic acid supplementation in actinomycetes
发明人：LEE HEI CHAN; SOHNG JAE KYUNG; SAN KA-YIU
权利人:LEE HEI CHAN; SOHNG JAE KYUNG; SAN KA-YIU; RICE UNIVERSITY
摘要:The invention relates to the synthesis of polyketides in Actinomycetes by overexpression of pantothenate kinase and supplementation with pantothenic acid. This results in increasing in vivo CoA production and thereby drives increased production of secondary metabolites, such as polyketides.

专利号:WO-9936546-A1
优先权日:1998-01-14
标 题 :Polyketides and their synthesis
发明人：LEADLAY PETER FRANCIS; STAUNTON JAMES; WILKINSON BARRIE; ROWE CHRISTINE JANET; BOHM INES UTE; BUSS ANTONY DAVID
权利人:GLAXO GROUP LTD; LEADLAY PETER FRANCIS; STAUNTON JAMES; WILKINSON BARRIE; ROWE CHRISTINE JANET; BOHM INES UTE; BUSS ANTONY DAVID
摘要:The present invention provides an extended polyketide synthase gene assembly comprising a loading module and a plurality of extension modules wherein a second nucleic acid portion, encoding at least one extension module, has been inserted into a first nucleic acid portion encoding the loading module and at least one, and preferably a plurality, of extension modules. Such extended genes are useful in the production of novel macrolides of larger size than the natural product, for example 16-membered ring macrolides instead of 14-membered ring macrolides.

专利号:CN-1052488-C
优先权日:1996-01-18
标题 :One-step synthesis of meocamycin production process

专利号:EP-3048174-A1
优先权日:2015-01-21
标 题:Procedure for the rapid determination of bacterial susceptibilty to antibiotics that inhibit protein synthesis