CAS: 5129-59-9; Methyl 13-Methyltetradecanoate

相似化合物

2519-37-1 1118-77-0 111-82-0

上下游产品

methanol 13-methyltetradecanoic acid Methyl 13-methyl-12-tetradecenoate (2R,3R)-3-Hydroxy-2-(13'-methyltetradecanoylamino)-15-methylhexadecanesulfonic acidtunicamycin V 13-methyltetradecanoic acid

📜10-Carbomethoxydecyltriphenylphosphonium Bromide置于palladium On Activated Carbon,氢气,Sodium Hexamethyldisilazane体系中,用 四氢呋喃,乙醇 作为反应溶剂,化学反应 22.83H,反应生成 13-甲基十四烷酸甲酯
参考文献:扩展支链脂肪酸的构效关系:不饱和度和支链基团大小对抗癌活性的影响.
标题:扩展支链脂肪酸的构效关系:不饱和度和支链基团大小对抗癌活性的影响.
摘要:支链脂肪酸(bcfa)是一类具有非常好抗癌活性的脂肪酸.bcfa 13-甲基十四烷酸(13-Mtd)在体内抑制肿瘤生长而无毒性,但功效受限于中等效力,这是所有已知bcfa共有的特性.bcfas的作用机理尚未完全阐明,在缺乏明确定义的靶标的情况下,Bcfa效能的优化必须依赖于结构-活性关系.我们目前对促进bcfa抗癌活性的结构特征的理解受到所报道的bcfa的低结构多样性的限制.本研究的目的是研究两种新的结构修饰-不饱和和支链基团大小-对bcfa活性的影响.因此,饱和和顺式的同源序列合成了带有甲基,乙基,丙基和丁基支化基团的-δ11不饱和bcfa,并在体外针对三种人类癌细胞系进行了筛选.将新bcfa的效力与13-Mtd和带有顺式-δ11双键的直链单未饱和脂肪酸(mufa)进行了比较.出现的主要发现是,Bcfa的抗癌活性受到较大分支基团的不利影响,但通过在bcfa烷基链中引入顺式-δ11双键而显着
DOI:10.1016/j.Chemphyslip.2020.104952

专利信息

专利号:US-6214875-B1
优先权日:1998-04-14
标题:Anticancer effects of specific branched-chain fatty acids and related production process
发明人：YANG ZHENHUA
摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.

专利号:US-7070965-B1
优先权日:1998-04-14
标 题:Small molecule anticancer compounds and related production process
发明人：YANG ZHENHUA
权利人:YANG ZHENHUA
摘要:A group of specific branched-chain fatty acids, with significant anticancer effects on human and animals; methods of making using either chemical synthesis or biosynthesis methods; and methods of treating cancer.