CAS: 50528-86-4; 1-Chloro-2-Isocyanato-4-(Trifluoromethyl)Benzene

上下游产品

CAS号32315-10-9 三光气 | CAS号121-50-6 3-氨基-4-氯三氟甲苯 | CAS号328-26-7 2-氯-N-(2-氯-5-(三... | CAS号501684-93-1 NS 1738

📜三光气,3-氨基-4-氯三氟甲苯 反应生成 异氰酸-2-氯-5-(三氟甲基)苯酯
参考文献:吡唑并[5,1-D] [1,2,3,5]四嗪-4(3H)酮的除草类似物的设计,合成及定量构效关系研究.
标题:吡唑并[5,1-D] [1,2,3,5]四嗪-4(3H)酮的除草类似物的设计,合成及定量构效关系研究.
摘要:设计,合成了一系列吡唑并[5,1-D] [1,2,3,5] Tetrazin-4(3H)one衍生物,并评估了它们的除草活性,其中某些化合物提供了> 80%的除草效果.甘蓝型油菜(brassica Campestris)为10微克/毫升.使用理化参数(电子,Verloop或疏水性)作为独立参数,以除草活性为依存参数对这些化合物进行定量构效关系研究,其中除草活性与这组化合物中的理化参数最佳相关(r> 0.8)分子.r1的摩尔折光率(mr),R2或r6的塔夫脱(eso),R3或r5的verloop(lm)以及r4的电子参数(hammett常数)主要影响对野菜双歧杆菌的除草活性.除草活性的最佳mr为0.95.e菜的除草活性主要与取代基的疏水参数有关.r1和r4除草活性的最佳pi参数分别为0.72和0.68.通常,这些化合物对野菜双歧杆菌显示的除草活性比克鲁斯大肠埃希菌更大.
DOI:10.1021/jf063271N

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:CN-111471171-B
优先权日:2019-01-24
标 题:A kind of aryl sulfonic acid intermediate and its preparation method, and its application for the synthesis of low temperature sensitive admixture for concrete