CAS: 500-22-1; Nicotinaldehyde

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CAS号1120-90-7 3-碘吡啶 | CAS号201230-82-2 carbon monoxide | CAS号100-54-9 3-氰基吡啶 | CAS号626-55-1 3-溴吡啶 | CAS号100-55-0 3-吡啶甲醇 | CAS号59-26-7 尼可刹米 | CAS号98-92-0 烟酰胺 | CAS号10400-19-8 烟酰氯 | CAS号108-99-6 3-甲基吡啶 | CAS号95091-91-1 N-甲氧基-N-甲基烟酰胺 | CAS号105868-53-9 Methanediol, 3-... | CAS号110684-48-5 N-(4-methylphen... | CAS号105688-89-9 5-(1,3-dioxolan... | CAS号105192-41-4 (2-氨基-5-氯苯基)-3-吡啶甲酮 | CAS号104742-85-0 2-piperidin-1-y... | CAS号494-97-3 原烟碱 | CAS号5654-97-7 7-氮杂-吲哚-2-酮 | CAS号5424-19-1 3-苯酰基嘧啶 | CAS号34834-67-8 3'R,5'S)-3'-羟基可替宁 | CAS号3731-52-0 吡考胺

3-氨甲基吡啶置于4-Phenylnaphthalene-1,2-Dione,四丁基碘化铵体系中,用 水,乙腈 作为反应溶剂,化学反应 24.0H,反应生成 3-吡啶甲醛
参考文献:通过串联邻萘醌催化和 Tbhp 促进的氧化序列将伯胺一锅直接氧化成羧酸
标题:通过串联邻萘醌催化和 Tbhp 促进的氧化序列将伯胺一锅直接氧化成羧酸
摘要:胺到羧酸的串联氧化序列是通过o-Nq 催化的胺有氧氧化成亚胺,然后是自由基引发的 Tbhp 促进的亚胺中间体氧化.从机制上讲,通过 Tbai 的帮助促进了o-Nq 催化剂体系的选择性亚胺形成,这在随后 Tbhp 促进的亚胺衍生物氧化以将亚胺分解为醛和胺中也很关键.反过来,释放的胺重新进入o-Nq 催化循环以产生亚胺中间体.
DOI:10.1002/chem.202103450

专利信息

专利号:US-5549974-A
优先权日:1994-06-23
标题:Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
发明人：HOLMES CHRISTOPHER P
权利人:AFFYMAX TECH NV
摘要:The invention provides an efficient and versatile method for the combinatorial synthesis and screening of libraries of 4-thiazolidinones, metathiazanones, and derivatives thereof. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. Arrays of thiazolidinones, metathiazanones, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antihistaminic, or antimicrobial activity or use in the treatment of inflammation, hypertension, renal failure, congestive heart failure, uremia and other conditions can be prepared using this method.

专利号:US-5817751-A
优先权日:1994-06-23
标 题 :Method for synthesis of diketopiperazine and diketomorpholine derivatives
发明人：SZARDENINGS ANNA KATRIN; CAMPBELL DAVID
权利人:AFFYMAX TECH NV
摘要:The present invention relates to the areas of organic and medicinal chemistry. More specifically, the present invention is concerned with combinatorial and solid phase methods for the synthesis of diverse diketopiperazine derivatives, and the use of such methods to create libraries of diverse diketopiperazine derivatives. The present invention has application in the areas of chemical synthesis, the screening for new diketopiperazine derivatives having beneficial medical properties and the use of such screening to provide compositions and methods including diketopiperazine derivatives for treating disease.

专利号:US-5973157-A
优先权日:1997-04-18
标题 :Process for the synthesis of 1,7-diarly or heteroaryl-heptane-4-ols and new synthetic intermediates
发明人：STIVANELLO MARIANO
权利人:FABBRICA ITALIANA SINTETICI SPA
摘要:This invention offers a process for the synthesis of a compound of the formula ##STR1## wherein R' is a phenyl, a substituted phenyl, a heterocyclic aromatic group, a heterocyclic aromatic substituted group, a linear or branched alkyl group, or a cycloalkyl group. n The invention also comprises the following compounds of a formula 1' and 2' as useful new synthesis intermediates. ##STR2## wherein R is a phenyl, a substituted phenyl, an alkyl, a cycloalkyl and X is Cl, Br, I, F, CH 3 SO 3 , p--CH 3 --C 6 H 4 --SO 3 .

专利号:WO-03031376-A1
优先权日:2001-10-12
标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
发明人：MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:US-7176223-B2
优先权日:2001-09-05
标题 :Method for synthesis of 5-(3-pyridylmethylene-)imidazolidine-2,4-dione
发明人：CALLENS ROLAND
权利人:SOLVAY
摘要:Process for the synthesis of 5-(3-pyridylmethyl)imidazolidine-2,4-dione, according to which 5-(3-pyridylmethylene)imidazolidine-2,4-dione is subjected to a hydrogenation reaction.