CAS: 4942-47-6; 2-(Adamantan-1-yl)Acetic Acid

该化合物是一种化学化合物,其特点是独特的坚固结构,这是一种多环碳氢化合物,以其稳定性和僵硬性闻名,该化合物具有附属于坚固的烷基框架的碳酸性功能组(-COOH),其酸性能有所增强.该化合物通常是在室内温度下的一种白色晶状固体,在有机溶剂中可溶解,尽管其在水中的溶解性有限.该亚坦那河水分的存在具有独特的性能和电子特性,使其在各个领域,包括药用化学和材料科学中具有兴趣.1-Adamanteaneatheratherather酸可能展示生物活动,其衍生物往往被探索用于潜在的治疗用途.此外,其结构特性允许进行可能的改变,从而能够加强其特性或生物活动.

结构式图片

相似化合物

6240-11-5 16269-13-9 15782-66-8

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号27174-71-6 1-金刚烷乙酸甲酯 | CAS号144-55-8 碳酸氢钠 | CAS号104543-11-5 2-(1-adamantyl)... | CAS号15782-66-8 1-Adamantaneace... | CAS号144499-21-8 2-(adamantan-1-... | CAS号16269-13-9 1-金刚烷乙睛 | CAS号75-35-4 1,1-二氯乙烯 | CAS号32314-61-7 1-adamantyl nitrate | CAS号56531-58-9 3-羧基-1-金刚烷乙酸 | CAS号17768-36-4 3-羟基金刚烷-1-乙酸 | CAS号17768-41-1 1-金刚烷甲胺 | CAS号19835-39-3 1-ADAMANTAN-1-Y... | CAS号19026-73-4 tricyclo[3.3.1.... | CAS号19835-38-2 1-金刚烷乙酰氯 | CAS号773-37-5 1-(2-溴乙基)金刚烷 | CAS号15782-66-8 1-Adamantaneace... | CAS号6240-11-5 1-羟乙基金刚烷 | CAS号17768-29-5 1,3-金刚烷二羧酸二甲酯

合成工艺路线路线简述

  • 合成目标产物 1-Adamantaneacetic Acid 主要起始原料 Methyl 2-(1-Adamantyl)Acetate And Sodium Bicarbonate
  • (文献来源)合成步骤主要原料 Methyl 2-(1-Adamantyl)Acetate 和 Sodium Bicarbonate
1-金刚烷乙酰氯置于sodium Hydroxide,硫酸,水体系中,用 甲苯 作为反应溶剂,化学反应 1.0H,反应生成 1-金刚烷乙酸
参考文献:
标题:
摘要:
DOI:10.1023/a:1025508823764

海关参考信息

专利信息


专利号:US-2013133483-A1
优先权日:2010-03-08
标题 :Synthesis of Nanoparticles Using Reducing Gases
发明人:YANG HONG; WU JIANBO; SHI MIAO; GROSS ADAM
权利人:YANG HONG; WU JIANBO; SHI MIAO; GROSS ADAM; UNIV ROCHESTER
摘要:Selective gas-reducing methods for making shape-defined metal-based nanoparticles. By avoiding the use of solid or liquid reducing reagents, the gas reducing reagent can be used to make shape well-defined metal- and metal alloy-based nanoparticles without producing contaminates in solution. Therefore, the post-synthesis process including surface treatment become simple or unnecessary. Weak capping reagents can be used for preventing nanoparticles from aggregation, which makes the further removing the capping reagents easier. The selective gas-reducing technique represents a new concept for shape control of nanoparticles, which is based on the concepts of tuning the reducing rate of the different facets. This technique can be used to produce morphology-controlled nanoparticles from nanometer- to submicron- to micron-sized scale. The Pt-based nanoparticles show improved catalytic properties (e.g., activity and durability).

专利号:US-6924375-B2
优先权日:2003-09-03
标题:Facile synthesis of 1,9-diacyldipyrromethanes
发明人:LINDSEY JONATHAN S; TAMARU SHUN-ICHI; YU LIANHE
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention provides a method of making a metal complex. The method comprises the steps of: (a) acylating a dipyrromethane or a 1-monoacyldipyrromethane to form a mixed reaction product comprising a 1,9-diacyidipyrromethane; (b) combining the reaction product with a compound of the formula R 2 MX 2 in the presence of a base, where R is alkyl or aryl, M is Sn, Si, Ge, or Pb (preferably Sn), and X is halo, OAc, acac, or OTf, to form a product comprising a metal complex of the formula DMR 2 in the mixed reaction product, wherein D is a 1,9-diacyldipyrromethane; and then (c) separating the metal complex from the mixed reaction product. The method may be utilized for the convenient synthesis and separation of 1,9-diacyldipyrromethanes. Metal complex intermediates useful in such methods are also described.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-5856107-A
优先权日:1997-02-04
标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TREGA BIOSCIENCES INC
摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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主要参考文献

[参考文献]: Magorzata Sleszyńska, Et Al. Novel Bradykinin Analogues Modified In The N-Terminal Part Of The Molecule With A Variety Of Acyl Substituents. Int J Pept Res Ther. 2012 Jun;18(2):117-124.

合成参考文献


摘要:Bietti, M.; Dénès, F., Science of Synthesis, (2021) , 561.
摘要:Vicens, L.; Palone, A.; Costas, M., Science of Synthesis: Base-Metal Catalysis, (2023) 2, 483.
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