专利号:US-2012302756-A1 优先权日:2010-02-19 标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines 发明人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR 权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR 摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.
专利号:US-7919630-B2 优先权日:2005-09-30 标题 :Synthesis of imidazole 2-thiones via thiohydantoins 发明人:GARST MICHAEL E; DOLBY LLOYD J; ESFANDIARI SHERVIN; AVEY JR ALFRED A; MACKENZIE VIVIAN ROSE; MUCHMORE CHARLES DAVID 权利人:ALLERGAN INC 摘要:The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione.
专利号:US-8338620-B2 优先权日:2007-04-03 标 题:Methods for the production of C-8 lactam lactone compounds 发明人:SEDELMEIER GOTTFRIED 权利人:SEDELMEIER GOTTFRIED; NOVARTIS AG 摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, the invention relates to a process for the manufacture of a compound of the formula I, n nor a salt thereof, wherein R1 as well as Act are as defined in the specification, and processes of manufacturing this compound as well as intermediates in this process.
专利号:US-7402670-B2 优先权日:2004-09-30 标 题:Synthesis by chiral diamine-mediated asymmetric alkylation 发明人:DENG XIAOHU; MANI NEELAKANDHA 权利人:JANSSEN PHARMACEUTICA NV 摘要:Chiral synthesis from an achiral starting material by chiral diamine-mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid.
专利号:US-2020407381-A1 优先权日:2018-03-20 标题:C-bulky p-chirogenic organophosphorus compounds 发明人:BAYARDON JÉRÔME; JAILLET ANTONIN; JUGÉ SYLVAIN 权利人:UNIV BOURGOGNE 摘要:In the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds, a process for the synthesis of compound of formula (I). This process is especially useful to obtain chiral bulky phosphorus compounds. The present invention also relates to compounds of formula (VII), (VIII), (IX) and (X) and their processes of manufacturing starting from a compound of formula (I).
专利号:US-2007203344-A1 优先权日:2005-09-30 标 题 :Synthesis of imidazole 2-thiones via thiohydantoins
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