CAS: 492-08-0; (7R,7Ar,14R,14As)-Dodecahydro-2H,6H-7,14-Methanodipyrido[1,2-A:1',2'-E][1,5]Diazocine

该化合物是自然产生的藻类,主要产自植物物种*Lupinus*(卢皮克斯),其特征是其手性结构,由于立体中心的存在而表现出光学活动,有助于其反美形式,化合物的分子式为C11H14N2,具有包括管状环在内的双环结构. (+)-斯巴丁因其在协调化学方面所起的作用而闻名,并应用于不对称合成,特别是在形成手性化合物方面.它显示出有机溶剂中的中等溶液,在标准条件下相对稳定.此外,(+)-斯巴丁因对其药性特性进行了研究,包括其对...

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2,3,4,5-tetrahydropyridine d,l-lupanine 1,5-diaminopentane dihydr°Chloride(-)-sparteine t)-1,3,4,7,9,10,11,13,14,14a-decahydro-2H,6H-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cine(+/-)-(14at)-1,3,4,7,9,10,11,13,14,14a-decahydro-2H,6H-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cine c,14at)-dodecahydro-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cin-6-one(+/-)-(7ac,14at)-dodecahydro-7r,14c-methano-dipyrido[1,2-a;1',2'-e][1,5]diaz°Cin-6-one 17-oxosparteine

合成工艺路线路线简述

    📜2-吡啶乙酸乙酯置于1,4-二氧六环,(1R)-2-Oxo-Bornane-10-Sulfonic Acid,Copper Oxide-Chromium Oxide,乙酸酐体系中,250.0~265.0 °C,34.32 Mpa 条件下,反应生成 (+)-鹰爪豆碱
    参考文献:Land Reform,Poverty Reduction,And Growth: Evidence From India
    标题:Land Reform,Poverty Reduction,And Growth: Evidence From India
    摘要:近年来,人们对再分配,增长和福利之间关系的兴趣再度上升.发展中国家的土地改革通常旨在改善贫困人口对土地的获取,尽管其有效性常常受到实施过程中政治限制的阻碍.在本文中,我们使用1958年至1992年间印度十六个主要邦的面板数据,来探讨法律规定的土地改革是否对经济增长和贫困产生了显著影响.我们认为,这类土地改革与减贫之间存在关联.
    DOI:10.1162/003355300554809

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    专利信息


    专利号:US-2012302756-A1
    优先权日:2010-02-19
    标 题 :Process for synthesis of 2-substituted pyrrolidines and piperadines
    发明人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
    权利人:LELETI RAJENDER REDDY; LIU YUGANG; PRASHAD MAHAVIR
    摘要:The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.

    专利号:US-7919630-B2
    优先权日:2005-09-30
    标题 :Synthesis of imidazole 2-thiones via thiohydantoins
    发明人:GARST MICHAEL E; DOLBY LLOYD J; ESFANDIARI SHERVIN; AVEY JR ALFRED A; MACKENZIE VIVIAN ROSE; MUCHMORE CHARLES DAVID
    权利人:ALLERGAN INC
    摘要:The present invention provides a method of making an imidazole 2-thione which comprises the step(s) of reducing a thiohydantoin to said imidazole-2-thione.

    专利号:US-8338620-B2
    优先权日:2007-04-03
    标 题:Methods for the production of C-8 lactam lactone compounds
    发明人:SEDELMEIER GOTTFRIED
    权利人:SEDELMEIER GOTTFRIED; NOVARTIS AG
    摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, the invention relates to a process for the manufacture of a compound of the formula I, n nor a salt thereof, wherein R1 as well as Act are as defined in the specification, and processes of manufacturing this compound as well as intermediates in this process.

    专利号:US-7402670-B2
    优先权日:2004-09-30
    标 题:Synthesis by chiral diamine-mediated asymmetric alkylation
    发明人:DENG XIAOHU; MANI NEELAKANDHA
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:Chiral synthesis from an achiral starting material by chiral diamine-mediated, such as sparteine-mediated, intermolecular asymmetric alkylation with a strained cyclic ether in the presence of a Lewis acid.

    专利号:US-2020407381-A1
    优先权日:2018-03-20
    标题:C-bulky p-chirogenic organophosphorus compounds
    发明人:BAYARDON JÉRÔME; JAILLET ANTONIN; JUGÉ SYLVAIN
    权利人:UNIV BOURGOGNE
    摘要:In the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds, a process for the synthesis of compound of formula (I). This process is especially useful to obtain chiral bulky phosphorus compounds. The present invention also relates to compounds of formula (VII), (VIII), (IX) and (X) and their processes of manufacturing starting from a compound of formula (I).

    专利号:US-2007203344-A1
    优先权日:2005-09-30
    标 题 :Synthesis of imidazole 2-thiones via thiohydantoins

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Piotrovskiĭ VK, Belolipetskaia VG, Rumiantsev DO, Metelitsa VI. [The polymorphism of pachycarpine oxidation]. Eksp Klin Farmakol. 1992 Jul-Aug;55(4):56-8. Russian. doi: 10.1002/cmdc.201700568. Epub 2017 Nov 6. doi: 10.1016/j.chemosphere.2017.10.165. Epub 2017 Oct 30. doi: 10.1080/14756366.2017.1279156.
    5: ANISIMOVA MI. [Acceleration of labor with pachycarpine]. Akush Ginekol (Mosk). 1953 Jul-Aug;4:35-7. Undetermined Language. doi: 10.1016/j.seizure.2016.05.010. Epub 2016 May 24. Review. German. Undetermined Language. pii: E2102. doi: 10.3390/molecules22122102.
    10: SHASS EIu. [Pachycarpine]. Feldsher Akush. 1954 Jan;1:52-4. Undetermined Language. doi: 10.1039/c4cc02135e. doi: 10.1016/j.etp.2016.10.005. Epub 2016 Nov 5. Russian. doi: 10.1007/s00284-018-1573-2. Epub 2018 Sep 28.

    合成参考文献


    摘要:Ganglion-Blocking and Ganglion-Stimulation Agents, Kharkevich, D.A., Moscow, First Moscow Medical Institute, 1967, -(175), 1967
    摘要:Shaanxi Xinyiyao. Shaanxi New Medical., 11(6)(53), 1982
    摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 432.
    参考文献:10.1007/bf01388170
    摘要:Calmes M, Daunis J. How to build optically active alpha-amino acids. Amino Acids. 1999;16(3-4):215–50. doi: 10.1007/bf01388170.
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