CAS: 4786-20-3; 2-Butenenitrile

上下游产品

4-Chlorobutyronitrile 2-hydroxybutanenitrile (+-)-3-amino-butyronitrile 3-hydroxybutanenitrilecrotylamine 3-dibenzylphosphinoyl-butyronitrile 3-tosylbutanenitrile β-bromobutyronitrile

烯丙基腈 999.84 °C,10.0 Pa 条件下,以11%的收率获得产物2-丁烯腈
参考文献:寻找杂芳族环和相关异构体作为星际候选物
标题:寻找杂芳族环和相关异构体作为星际候选物
摘要:在星际介质(ism)中寻找复杂的有机分子是理解星际有机化学在益生元物种合成中可能发挥作用的主要关注点.本跨学科报告是一项前瞻性研究,旨在帮助检测ism中的杂芳族化合物或至少某些其异构体.使用密度泛函理论(dft)计算了c 4 H 5 N,C 4 H 4 O,C 4 H 4 S族的热力学稳定性.发现吡咯,呋喃 和 噻吩在ism的10-50 K温度下,它们无疑是最稳定的异构体.合成了几种不太稳定的异构体,并对这些物种进行了快速真空热解实验.尽管在文献中已经报道了在许多化合物热解中检测吡咯的方法,但我们观测到在这些条件下,没有异构体导致吡咯,这表明需要考虑其他形成途径.另一方面,这三种芳族化合物具有很高的稳定性,在闪速真空热解下,在1500 K下几乎没有%的化合物分解.这些实验也显示出很大的稳定性巴豆腈这是在这些条件下可以形成的最稳定的化合物.给出了低洼异构体的旋转常数,偶极矩和ir频率,以鼓励对这些原型分子进行实验室实验.
DOI:10.1039/b924574J

专利信息

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-9567293-B2
优先权日:2013-02-08
标题 :Combined synthesis of a nitrile-ester/acid and of a diester/diacid
发明人：DUBOIS JEAN-LUC; COUTURIER JEAN-LUC; BRANDHORST MARKUS
权利人:ARKEMA FRANCE
摘要:A method for the combined synthesis of a mono-unsaturated nitrile-ester(acid) and of a bi-functional carbonyl compound, wherein it includes a step including the cross metathesis mc1 of an unsaturated fatty acid/ester compound with an unsaturated nitrile compound, in which mc1 is performed with partial conversion such as to obtain and recover, separately, at least the following products: a mono-unsaturated nitrile-ester/acid and a symmetrical compound, diester or diacid respectively including a double bond located in the middle of the molecular chain of compound, and subsequently a step including the oxidation cleavage cp2 of the double bond of compound, such as to form a single type of carbonyl compound having formula R2-(CH2)n-COR′, in which R′ is H or OH, depending on the operating conditions selected for the oxidation cleavage cp2. Also, the production of monomers for the polymer industry.

专利号:US-3781324-A
优先权日:1969-11-03
标 题:Certain 6-trifluoromethylcytosines and thiocytosines,their synthesis,and their use in the synthesis of uracils and thiouracils
发明人：LUTZ A
权利人:AMERICAN CYANAMID CO
摘要:3-AMINO-2-SUBSTITUTED - 4,4,4 - TRIFLUORO-2-BUTENENITRILES ARE REACTED WITH ISOCYANATES OR ISOTHIOCYANATES IN THE PRESENCE OF AN INERT SOLVENT AND FROM 0.75 TO ABOUT 1.0 MOLE EQUIVALENTS OF STRONG BASE PER MOLE OF BUTENENITRILE TO PRODUCE THE NOVEL UREIDO BUTENENITRILES OF THE FORMULA: CF3-C(-NH-C(=X)-NH-R)=C(-HALO)-CN WHEREIN R IS ALKYL, ALKENYL, PHENYL, BENZYL AND SUBSTITUTED DERIVATIVES THEREOF AND X IS SULFUR OR OXYGEN. THE UREIDO BUTENENITRILE ARE TREATED WITH ADDITIONAL BASE TO PRODUCE NOVEL CYCLIC CYTOSINES OF THE FORMULA: 6-CF3,5-HALO,4-(HN=),3-R,2-(X=)-1,2,3,4-TETRAHYDRO- PYRIMIDINE WHEREIN R AND X ARE AS DEFINED ABOVE. THE CYTOSINES CAN BE PRODUCED DIRECTLY BY TREATING 3-AMINO-2-SUBSTITUTED4,4,4-TRIFLUORO-2-BUTENENITRILE WITH AT LEAST 1.0 MOLE EQUIVALENT OF BASE. THE NOVEL COMPOUNDS ARE USEFUL INTERMEDIATES IN THE PREPARATION OF HERBICIDAL URACILS AND THIOURACILS.

专利号:US-3635977-A
优先权日:1969-11-03
标 题 :Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
发明人：LUTZ ALBERT WILLIAM
权利人:AMERICAN CYANAMID CO
摘要:3 - AMINO - 2 - SUBSTITUTED - 4,4,4 - TRIFLUORO - 2 - BUTENENITRILES ARE REACTED WITH ISCYANATES OR ISOTHIOCYANATES IN THE PRESENCE OF AN INERT SOLVENT AND FROM 0.75 TO ABOUT 1.0 MOLE EQUIVALENTS OF STRONG BASE PER MOLE OF BUTENENITRILE TO PRODUCE THE NOVEL UREIDO BUTENEITRILES OF THE FORMULA: NC-C(-HALO)=C (-CF3)-NH-C(=X)-NH-R PYRIMIDINE WHEREIN R IS ALKYL, ALKENYL, PHENYL, BENZYL AND SUBSITUTED DERIVATIVES THEREOF AND X IS SULFUR OR OXYGEN. THE UREIDO BUTENENITRILES ARE TREATED WITH ADDITIONAL BASE TO PRODUCE NOVEL CYCLIC CYTOSINES OF THE FORMULA; 2(=X),3-R,4-(=NH),5-(HALO-),6-(F3C-)-1,2,3,4-TETRAHYDRO WHEREIN R AND X ARE AS DEFINED ABOVE. THE CYTOSINES CAN BE PRODUCED DIRECTLY BY TREATING 3-AMINO-2-SUBSITUTED4,4,4-TRIFLUORO-2-BUTENENTRILE WITH AT LEAST 1.0 MOLE EQUIVLAENTS OF BASE. THE NOVEL COMPOUNDS ARE USEFUL INTERMEDIATES IN THE PREPARATION OF HERBICIDAL URACILS AND THIOURACILS.

专利号:US-2003068317-A1
优先权日:2001-04-20
标题:High capacity methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
发明人：LEE WILLIAM; SAITO KYOICHI
摘要:Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.

专利号:US-2008070274-A1
优先权日:2001-12-10
标 题 :High capacity, methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
发明人：LEE WILLIAM; SAITO KYOICHI
权利人:LEE WILLIAM; SAITO KYOICHI
摘要:Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.