CAS: 467-55-0; (2As,4S,5'R,6As,6Bs,8As,8Br,9S,10R,11As,12As,12Br)-4-Hydroxy-5',6A,8A,9-Tetramethylicosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-8(2H)-One

该化合物是一种自然产生的类固醇树脂素,产自各种植物来源,特别是原生虫阿盖夫,其特点是分子结构,包括一种具有有助于其生物活动的特定功能组群的类固醇主干体,它是一种白色的脱白晶状粉,在水中无法溶解,但在乙醇和氯仿等有机溶剂中可溶解,它的化学配方是C27H44O3,其分子重量约为41.665克/摩尔,它因其潜在的药理特性而著称,包括反炎和抗癌活动,因此对药用化学和药物研究感兴趣,此外,它作为各种类固醇激素和其他生物活性化合物合成的前体,由于其自然起源和生物意义,它被研究用于传统医药和现代治疗配方.

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CAS号915-35-5 乙酸龙舌兰皂苷酯 | CAS号2137-20-4 hecogenone | CAS号6875-60-1 蒺藜苷元 | CAS号28180-63-4 (25R)-2α,3α-epo... | CAS号108747-55-3 12-methylenetig... | CAS号38673-31-3 (25R)-5α-Spiros... | CAS号467-55-0 海柯皂苷元 | CAS号1106-20-3 (3β,5Alpha,25R)... | CAS号378-44-9 倍他米松 | CAS号915-35-5 乙酸龙舌兰皂苷酯 | CAS号987-24-6 醋酸倍他米松 | CAS号467-55-0 海柯皂苷元 | CAS号126-19-2 菝葜皂苷元; 菝葜皂甙元

合成工艺路线路线简述

    (25R)-3β-[{o-β-D-Xylopyranosyl-(1->3)-O-β-D-Glucopyranosyl-(1->2)-O-[β-D-Xylopyranosyl-(1->3)]-O-β-D-Glucopyranosyl-(1->4)-β-D-Galactopyranosyl}Oxy]-5α-Spirostan-12-One置于盐酸体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 2.0H,以3.4 Mg的收率获得产物海柯吉宁
    参考文献:来自pol菜地上部分的类固醇糖苷.
    标题:来自pol菜地上部分的类固醇糖苷.
    摘要:化学分析了aerial菜(polianthes Tuberosa)的地上部分,结果分离出了一种新的双去胆固醇胆甾烷糖苷(1)和三种新的螺固醇皂苷(2-4),以及一种已知的胆甾烷苷.通过光谱分析确定新糖苷的结构,包括2D NMR光谱数据和水解裂解的结果.评价分离的化合物对hl-60人早幼粒细胞白血病细胞的细胞毒性活性.
    DOI:10.1021/np000230R

    海关参考信息

    专利信息


    专利号:EP-1172094-B1
    优先权日:2000-07-13
    标题:Composition, particularly for cosmetics, comprising DHEA and/or precursor or derivative, and at least a compound which increases the synthesis of glycosaminoglycans
    发明人:ALLEC JOSIANE; CLEREN NATHALIE
    权利人:OREAL
    摘要:Cosmetic composition comprises: (a) dehydroepiandrosterone (DHEA) and/or a DHEA precursor or derivative; and (b) a compound that promotes glycosaminoglycan synthesis or a natural extract containing such a compound.

    专利号:US-2004005342-A1
    优先权日:2002-02-07
    标题 :Topical administration of ascorbic acid to reinforce the cohesion of the dermo-epidermal junction
    发明人:BERNERD FRANCOISE
    权利人:OREAL
    摘要:The present invention relates to the pharmaceutical or cosmetic use of a composition comprising, in a pharmaceutically or cosmetically acceptable medium, ascorbic acid or an analogue thereof to reinforce the cohesion of the dermo-epidermal junction. n The invention also relates to the pharmaceutical or cosmetic use of a composition comprising, in a pharmaceutically or cosmetically acceptable medium, ascorbic acid or an analogue thereof to increase the synthesis of tenascin and/or collagen VII. n The invention also relates to the use of ascorbic acid or of an analogue thereof to reinforce the cohesion of the dermo-epidermal junction of reconstructed skins.

    专利号:EP-3002290-B1
    优先权日:2007-06-19
    标 题:Synthesis of deoxycholic acid (dca)
    发明人:MORIARTY ROBERT M; DAVID NATHANIEL E; MAHMOOD NADIR AHMEDUDDIN; PRASAD ACHAMPETA RATHAN; SWARINGEN ROY A JR; REID JOHN GREGORY; SAHOO AKHILA KUMAR
    权利人:ALLERGAN SALES LLC

    专利号:US-5606041-A
    优先权日:1992-06-26
    标题:Process for steroidal peracyl glycosides
    发明人:BUSCH FRANK R; GOGGIN KATHLEEN D; LAMBERT JOHN F; SHINE RUSSELL J; WALINSKY STANLEY W
    权利人:PFIZER
    摘要:Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting α-cellobiosyl bromide heptaalkanoate and β-tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl β-O-cellobioside heptaalkanoate. The analogous preparations of hecogenin β-O-cellobioside heptaalkanoate 11-ketotigogenin β-O-cellobioside heptaalkanoate, and diosgenin β-O-cellobioside heptaalkanoate are also disclosed. The process provides both high β-anomeric selectivity and high yields.

    专利号:EP-3002290-A2
    优先权日:2007-06-19
    标 题 :Synthesis of deoxycholic acid (dca)

    专利号:CN-1401658-A
    优先权日:2002-09-13
    标题 :Process for synthesis of 2,4-O-di-alpha-L-pyranorhamnosyl-beta-D-pyranoglucosyldioscin
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    主要参考文献


    1: Gama KB, Quintans JS, Antoniolli AR, Quintans-Júnior LJ, Santana WA, Branco A, Soares MB, Villarreal CF. Evidence for the involvement of descending pain-inhibitory mechanisms in the antinociceptive effect of hecogenin acetate. J Nat Prod. 2013 Apr 26;76(4):559-63. doi: 10.1021/np3007342. Epub 2013 Feb 25. doi: 10.1016/j.ejphar.2012.02.043. Epub 2012 Mar 8. doi: 10.1016/j.toxrep.2016.06.004. eCollection 2016.
    4: Poza JJ, Rodríguez J, Jiménez C. Synthesis of a new cytotoxic cephalostatin/ritterazine analogue from hecogenin and 22-epi-hippuristanol. Bioorg Med Chem. 2010 Jan 1;18(1):58-63. doi: 10.1016/j.bmc.2009.11.018. Epub 2009 Nov 12. doi: 10.1016/j.bmc.2010.02.051. Epub 2010 Mar 1. doi: 10.1016/j.steroids.2013.02.015. Epub 2013 Mar 15. doi: 10.1124/dmd.112.048157. Epub 2013 Jan 31.
    9: Uchaipichat V, Mackenzie PI, Elliot DJ, Miners JO. Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone) "probes" for human udp-glucuronosyltransferases. Drug Metab Dispos. 2006 Mar;34(3):449-56. Epub 2005 Dec 28. doi: 10.1021/np501033u. Epub 2015 Apr 27. doi: 10.1016/j.steroids.2013.04.014. Epub 2013 May 3. Epub 2016 Sep 29. Epub 2005 Aug 31. doi: 10.1021/ol802122p.

    合成参考文献


    参考文献:10.1211/0022357044102
    摘要:Quílez AM, Saenz MT, García MD, de la Puerta R. Phytochemical analysis and anti-allergic study of Agave intermixta Trel. and Cissus sicyoides L. J Pharm Pharmacol. 2004 Sep;56(9):1185–9. doi: 10.1211/0022357044102.
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