CAS: 4584-49-0; 2-Chloro-N,N-Dimethylpropan-1-Amine Hydrochloride

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5407-04-5 999-81-5 109-54-6

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CAS号108-16-7 N,N-二甲基异丙醇胺 | CAS号108-14-5 2-氯-N,N-二甲基-1-丙胺 | CAS号303-14-0 N,N,beta-三甲基-10... | CAS号57616-63-4 1-Propanamine, ...

N,N-二甲基异丙醇胺置于氯化亚砜体系中,用 氯仿 作为反应溶剂,以95%的收率获得产物n,N-二甲氨基-2-氯丙烷盐酸盐
参考文献:侧链对叔胺官能化多肽的ph和热响应性的影响
标题:侧链对叔胺官能化多肽的ph和热响应性的影响
摘要:侧链上的ph的结构影响的系统调查和叔胺官能化聚(热响应性升-谷氨酸)s(ta-的pgs)中的溶液中进行.通过铜(i)催化的叠氮基叔胺与聚(γ-炔丙基-L-谷氨酸)(pplg)的叠氮化物-炔烃环加成点击反应有效合成了ta-Pgs聚合物.进行了比浊法测量,以表征ta-Pg在水溶液中的ph和温度诱导的相变,这表明该性质对氮的结构依赖性取代基团和1,2,3-三唑环与侧链中叔胺基团之间的"连接基".详细地讲,Ta-Pg的ph响应特性基本上由侧链中n-取代基团的疏水性决定,Ph转变点(ph T)随着n-取代基团疏水性的增加而降低,而ta Pg的温度响应性受n取代基或"连接基"的影响.具有中等n取代胺基(例如dea,Pr和pd)或支链"连接子"(例如iso-丙烯和2-甲基丙烯基)更可能表达因ph值变化而调整的lcst型相变.这项研究揭示的这些结构-属性关系将有助于开发ta-Pg在智能药物输送系统中的应用.©2013
DOI:10.1002/pola.27048

专利信息

专利号:US-7429670-B2
优先权日:2003-08-27
标题 :Synthesis of derivatives of ginkgolide C
发明人：NAKANISHI KOJI; JARACZ STANISLAV; STROMGAARD KRISTIAN
权利人:UNIV COLUMBIA
摘要:The subject invention provides ginkgolide C derivatives compounds having the structure: n n n n n n n n n n wherein R is H or -A-Ar,n where A is an alkyl group; and Ar is an aryl group, which may contain heteroatoms and may be unsubstituted or substituted by one to five substituents each selected from the group consisting of hydrogen, alkoxy, —CH 2 CO 2 R 4 , and —CH 2 CONR 5 R 6 ;n where R 4 is an alkyl group; and R 5 and R 6 are each, independently, hydrogen or a branched or unbranched alkyl group; n n n wherein R 1 is H or —COR 7 ,n where R 7 is alkyl, aryl or amino; n n wherein R 2 is present or absent, and when present is H, —COR 8 or —CO—Z—R 8 ;n where R 8 is alkyl, aryl or amino; and Z is oxygen; n n wherein R 3 is present or absent, and when present is —COR 9 ;n where R 9 is alkyl or aryl; n n wherein only one of R 2 or R 3 is present in the compound; n wherein only two of R, R 1 , R 2 and R 3 are H; and n wherein each of a and b designates a single covalent bond which is present or absent,n where bond a is present when R 3 is absent and bond b is present when R 2 is absent;n nor an optically pure enantiomer of the compound. Additionally, the subject invention provides methods of inhibiting the activity of a glycine receptor using these compounds.

专利号:US-4048211-A
优先权日:1976-05-10
标 题 :Modification of methadone synthesis process step
发明人：BARNETT CHARLES J
权利人:LILLY CO ELI
摘要:Alkylation of diphenylacetonitrile in methadone synthesis is carried out in presence of sodium hydroxide and DMF.

专利号:US-2005119336-A1
优先权日:2003-08-27
标 题:Synthesis of derivatives of ginkgolide C

专利号:UA-78297-C2
优先权日:2002-04-10
标 题:1- or 3-thiabenzonaphlhoazulene as inhibitors of tumour necrosis factor production and intermediates for synthesis thereof