CAS: 3775-73-3; (R)-3-Aminobutanoic Acid

相似化合物

58610-42-7 3775-72-2 158851-30-0

上下游产品

CAS号64838-60-4 Methyl (3S)-3-{... | CAS号394220-59-8 N-p-methoxybenz... | CAS号120686-16-0 (r)-3-氨基-3-甲基-丙酸叔丁酯 | CAS号21948-18-5 (S)-3-amino-4-m... | CAS号1067647-39-5 (R)-tert-butyl ... | CAS号623-43-8 巴豆酸甲酯 | CAS号67843-72-5 Z-Β-D-高丙氨酸 | CAS号159991-23-8 (R)-3-(B°C-氨基)丁酸 | CAS号120686-16-0 (r)-3-氨基-3-甲基-丙酸叔丁酯

(3R)-3-氨基丁酸叔丁酯置于三氟乙酸体系中,用 二氯甲烷 用作溶剂,化学反应 15.0H,以97%的收率获得(R)-3-氨基丁酸
参考文献:平行合成手性β-氨基酸
标题:平行合成手性β-氨基酸
摘要:使用高手性锂n-苄基-N-(α-甲基苄基)酰胺的共轭加成,完成了对映体纯度高的30个β-氨基酸阵列的平行不对称合成.该协议的实验简单性和高度实用性通过高15种α,β-不饱和酯的高效平行转化为相应β-氨基酸的对映体系列以高总收率和选择性进行了证明,且每个步骤的纯化步骤最少反应方案.
Doi:10.1016/j.Tetasy.2007.06.008

专利信息

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.

专利号:WO-2024148312-A1
优先权日:2023-01-06
标题 :Compositions, systems, and methods for amino acid synthesis
发明人：YANG YANG; CHENG LEI; BO ZHIYU
权利人:UNIV CALIFORNIA
摘要:A method of forming a non-canonical amino acid includes contacting a substrate, a photocatalyst, and an amino acid with a pyridoxal enzyme in a solution and providing light sufficient to form the non-canonical amino acid from the solution. Compositions, systems, and methods for amino acid synthesis are included. Further, engineered enzymes to catalyze diverse C-C and C-heteroatom bond forming reactions are included.

专利号:US-2023203550-A1
优先权日:2017-07-11
标题:Use of stereoselective transaminase in asymmetric synthesis of chiral amine

专利号:CN-115515937-A
优先权日:2020-05-08
标 题:Dimers for the synthesis of peptidomimetics

专利号:CN-114126619-A
优先权日:2019-05-09
标题 :Compounds for the synthesis of peptidomimetics

专利号:WO-9615111-A1
优先权日:1994-11-15
标 题:Method and intermediates for the synthesis of korupensamines