木榴油置于2-氯-1,3-双(2,6-二异丙基苯基)-1H-氯化咪唑,Cesium Fluoride体系中,用 邻二甲苯 用作溶剂,化学反应 24.0H,以66%的收率获得2-氟苯甲醚 参考文献:Phenofluormix: Practical Chemoselective Deoxyfluorination Of Phenols 标题:Phenofluormix: Practical Chemoselective Deoxyfluorination Of Phenols 摘要:A Practical Deoxyfluorination With Novel Deoxyfluorinating Reagent Phenofluormix,A Mixture Of N,N'-1,3-Bis(2,6-Diisopropylphenyl)Chloroimidazolium Chloride And Csf,Is Presented. Phenofluormix Overcomes The Challenges Associated With Hydrolysis Of Phenofluor. Phenofluormix Does Not Hydrolyze,Is Readily Available On Decagram Scale,And Is Storable In Air. In This Paper,We Demonstrate The Practicality Of The Reagent And Exhibit The Deoxyfluorination Of A Variety Of Phenols And Heterocycles. Doi:10.1021/ol5035518
专利号:US-2010191010-A1 优先权日:2007-07-02 标题 :Process for the synthesis of carbamates using co2 发明人:BOSMAN JORIS KAREL PETER; CARR ROBERT HENRY 权利人:HUNTSMAN INT LLC 摘要:Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO 2 in the presence of ionic liquids and optionally in the presence of a base.
专利号:US-2013184465-A1 优先权日:2010-09-30 标 题:Process for the synthesis of thio-triazolo-group containing compounds 发明人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL 权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE 摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
专利号:US-5783577-A 优先权日:1995-09-15 标题 :Synthesis of quinazolinone libraries and derivatives thereof 发明人:HOUGHTEN RICHARD A; OSTRESH JOHN M 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.
专利号:US-5098602-A 优先权日:1988-05-11 标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements 发明人:HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA 权利人:NIPPON MINING CO 摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k 专利号:US-11840519-B2 优先权日:2019-09-03 标 题 :Process for the synthesis of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)-phenyl]methyl]-3,6-dihydro-4-methyl-2.6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]amino]-butanoic acid (elagolix sodium salt) and intermediates of said process 发明人:LENNA ROBERTO; FASANA ANDREA; ORTIZ JERRY 权利人:IND CHIMICA SRL 摘要:The present invention to a process for the preparation of the sodium salt of 4-[[(1R)-2-[5-(2-fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]-3,6-dihydro-4-methyl-2,6-dioxo-1(2H)-pyrimidinyl]-1-phenylethyl]-amino]-butanoic acid, compound also known as Elagolix sodium salt, having the formula (I) reported below:
专利号:US-4453012-A 优先权日:1982-04-22 标 题 :Process for the preparation of phenyl ketones 发明人:DESBOIS MICHEL 权利人:RHONE POULENC SPEC CHIM 摘要:A process for the preparation of phenyl ketones, characterized in that, in a first stage, a halo- or trihalomethylbenzene is reacted with a trihalomethylated aliphatic or aromatic compound in the presence of boron trifluoride in an amount such that the absolute pressure of boron trifluoride within the reaction vessel exceeds 1 bar, and in the presence of hydrofluoric acid as a solvent, and in that, in a second stage, the resultant product is hydrolyzed. The products are used as intermediates in the synthesis of compounds having a pharmaceutical or phytosanitary (e.g., herbicidal) activity.