CAS: 30508-27-1; (R)-4-(7-Hydroxy-5-Methoxy-6-(3-Methylbut-2-En-1-yl)Chroman-3-yl)-2-(3-Methylbut-2-En-1-yl)Benzene-1,3-Diol
该化合物是一种自然形成的由食糖(甘油氏菌)产生的先热的异己拉夫酮化合物,它具有显著的生物活动,包括抗微生物,抗炎和潜在的抗癌特性.其结构特征是,它以甲状腺替代物为代表的亚甲状腺骨骼结构特征,利科里西丁表现出对抗微生物细菌的强烈抑制作用,使它成为抗微生物研究的候选体.它能够调节炎热途径,如NF-B抑制,突出其在慢性炎症条件下的治疗潜力.此外,初步研究显示,由于其多功能生物活动和自然来源,利科里西丁对开发新型治疗剂的医药和生物医学研究感兴趣.
- 英文名称(R)-4-(7-Hydroxy-5-Methoxy-6-(3-Methylbut-2-En-1-yl)Chroman-3-yl)-2-(3-Methylbut-2-En-1-yl)Benzene-1,3-Diol
- 中文名称甘草西定
- IUPAC名称(R)-4-(7-hydroxy-5-methoxy-6-(3-methylbut-2-en-1-yl)chroman-3-yl)-2-(3-methylbut-2-en-1-yl)benzene-1,3-diol
- 其它别名4-[(R)-7-Hydroxy-5-Methoxy-6-(3-Methyl-But-2-Enyl)-1-Benzopyran-3-Yl]-2-((E)-3-Methyl-But-2-Enyl)-Benzene-1,3-Diol; 4-[(3R)-7-Hydroxy-5-Methoxy-6-(3-Methylbut-2-Enyl)-3,4-Dihydro-2H-Chromen-3-Yl]-2-(3-Methylbut-2-Enyl)Benzene-1,3-Diol; Uni
- CAS编号30508-27-1
- MFCD编号:MFCD32182601
- FDA UNII编号:929XTD20VK
- 分子式:C26H32O5分子量:424.54
- 产品CID: 1290664
- 产品分类天然产物 → 黄酮类化合物
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
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2901220000-丙烯
2902600000-乙苯
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专利信息
专利号:WO-2006003227-A1
优先权日:2004-06-25
标题 :Synthesis of polyoxygenated nitrogen systems, comprising reactions between enamines of 1,3-dioxan-5-ones and nitroolefins
专利号:JP-2008527010-A
优先权日:2005-01-14
标 题 :Synthesis of narcystatin sodium and related compounds
专利号:CN-108440553-A
优先权日:2018-03-16
标题 :A ruthenium complex catalyzed asymmetric synthesis of optically pure glabridin
专利号:WO-2006076726-A1
优先权日:2005-01-14
标题 :Synthesis of sodium narcistatin and related compounds
专利号:WO-2006076726-A9
优先权日:2005-01-14
标题:Synthesis of sodium narcistatin and related compounds
专利号:EP-1845981-A4
优先权日:2005-01-14
标 题 :SYNTHESIS OF SODIUM NARCISTATIN AND ASSOCIATED COMPOUNDS
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主要参考文献
1: Park SY, Kwon SJ, Lim SS, Kim JK, Lee KW, Park JH. Licoricidin, an Active Compound in the Hexane/Ethanol Extract of Glycyrrhiza uralensis, Inhibits Lung Metastasis of 4T1 Murine Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jun 14;17(6). pii: E934. doi: 10.3390/ijms17060934.
2: Tanabe S, Desjardins J, Bergeron C, Gafner S, Villinski JR, Grenier D. Reduction of bacterial volatile sulfur compound production by licoricidin and licorisoflavan A from licorice. J Breath Res. 2012 Mar;6(1):016006. doi: 10.1088/1752-7155/6/1/016006. Epub 2012 Feb 27. doi: 10.1902/jop.2010.100342. Epub 2010 Aug 19. doi: 10.1017/S0007114510002114. Epub 2010 May 21. doi: 10.1021/np400788r. Epub 2014 Jan 30. doi: 10.1016/j.fitote.2015.05.003. Epub 2015 May 8. doi: 10.1021/np2004775. Epub 2011 Nov 10.
11: Kim KJ, Xuan SH, Park SN. Licoricidin, an isoflavonoid isolated from Glycyrrhiza uralensis Fisher, prevents UVA-induced photoaging of human dermal fibroblasts. Int J Cosmet Sci. 2017 Apr;39(2):133-140. doi: 10.1111/ics.12357. Epub 2016 Sep 8. doi: 10.1016/j.jpba.2015.08.013. Epub 2015 Aug 17. doi: 10.1111/j.1601-0825.2011.01842.x. Epub 2011 Aug 18. Review. doi: 10.3390/molecules190913027. doi: 10.1016/j.cbi.2018.05.007. Epub 2018 May 18. pii: E1286. Review. doi: 10.1016/j.taap.2017.04.015. Epub 2017 Apr 14.
合成参考文献
参考文献:10.5281/zenodo.5794106
摘要:The LOTUS Initiative for Open Natural Products Research: frozen dataset union wikidata (with metadata) | DOI:10.5281/zenodo.5794106
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